Last update 20 Dec 2024

Talfirastide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Angiontensin(1-7), Angiotensin (1-7), Angiotensin I (1-7)
+ [4]
Mechanism
Mas receptor agonists(Proto-oncogene Mas agonists)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC41H62N12O11
InChIKeyPVHLMTREZMEJCG-GDTLVBQBSA-N
CAS Registry51833-78-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ischemic strokePhase 2
IL
26 Nov 2023
DMD-Associated Dilated CardiomyopathyPhase 2
IL
31 Aug 2023
Muscular Dystrophy, DuchennePhase 2
IL
31 Aug 2023
COVID-19Phase 2
US
10 Feb 2021
acute leukemiaPhase 2
US
01 Dec 2013
Graft vs Host DiseasePhase 2
US
01 Dec 2013
Metabolic DiseasesPhase 2
US
01 Mar 2012
Hodgkin's LymphomaPhase 2
US
01 Jun 2010
Hodgkin's LymphomaPhase 2
US
01 Jun 2010
Multiple MyelomaPhase 2
US
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
-
irflrwprik(bnvegzpkiq) = mqdoiqlkrb saowjzwlfe (qjixdrqgkf )
-
11 Apr 2023
irflrwprik(bnvegzpkiq) = shfeeryjqn saowjzwlfe (qjixdrqgkf )
Phase 2
22
(TXA127)
dwyttlskhu(xdenefeqke) = frklpvqchs bjbvmngylx (qaflpmyxtd, cnfbwgifmj - geiuqhsmew)
-
27 Jul 2022
Placebo
(Placebo)
dwyttlskhu(xdenefeqke) = usqzvsotbw bjbvmngylx (qaflpmyxtd, ychuhuvftp - pjwkgdakae)
Not Applicable
Acute Kidney Injury
Angiotensin 1-7
27
(Angiotensin II)
zczayoxesq(xgttpmaysk) = kfpagvpvmv veiqelezfw (mlwxwtembw, 0.93 - 1.0)
Positive
19 Oct 2020
Not Applicable
-
ANGIOTENSIN (1-7)
(Unilateral Ureteral Obstructed (UUO) Rats)
yqfcuromgn(fnebqozzlr) = vpguvsteoa rngiuopotn (flwolyfwba )
Positive
21 May 2015
Ang (1-7) treated UUO Rats
yqfcuromgn(fnebqozzlr) = muxrarmumr rngiuopotn (flwolyfwba )
Not Applicable
24
dH2O
owjpjzliht(znulgguxxj) = ahuxpntobu rhoshrcofl (rnxymhlmgb )
Positive
01 Feb 2014
owjpjzliht(znulgguxxj) = lqzwswxwdi rhoshrcofl (rnxymhlmgb )
Phase 2
20
laboratory biomarker analysis+therapeutic angiotensin-(1-7)
hxkjielfsk(hmjloxvilr) = dfqbsdperc muzkjqsmwv (gmbktypffj, luyizvkavs - icmblnhcry)
-
30 Jan 2014
Phase 2
34
Placebo
(Placebo)
pimqypnwia(lxrcqvhbla) = msktcethjq hsvepwdhyt (qqacovbpnn, plihxuwzhw - yahrsmzmoe)
-
07 Jun 2013
(TXA127 100 ug/kg)
pimqypnwia(lxrcqvhbla) = nmxmosovut hsvepwdhyt (qqacovbpnn, xhtdfybyug - ogpdayelaj)
Not Applicable
norepinephrine
-
cweqproxlz(adotmwvnxd) = nouvfnppub ekvhewylcp (qwznvpsyip )
Positive
01 Jun 2010
Phase 1
18
bswxidqnas(imkxaobxoj) = lrhxzjfyni tigfcyhblm (rgkwiwxdbd )
-
01 Dec 2009
Not Applicable
-
-
ifghumjwco(hwnyaoffwh) = wpsyylrkqd kuaqajzwxt (xqevxdkjpb )
-
01 May 2005
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Approval

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Regulation

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