Last update 08 May 2025

Grazoprevir Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Grazoprevir, Grazoprevir anhydrous, 格拉佐韦
+ [2]
Target
Action
inhibitors
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors)
Active Indication
Originator Organization
Active Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (28 Sep 2016),
Regulation-
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Structure/Sequence

Molecular FormulaC38H52N6O10S
InChIKeyRXSARIJMSJWJLZ-CIAYNJNFSA-N
CAS Registry1350462-55-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
Japan
28 Sep 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FibrosisPhase 3-09 May 2014
Hepatitis C, ChronicPhase 3-09 May 2014
Chronic Kidney DiseasesPhase 3-17 Mar 2014
HIV InfectionsPhase 2
France
31 May 2017
Chronic hepatitis C genotype 2Phase 2-28 Nov 2011
Chronic hepatitis C genotype 3Phase 2-28 Nov 2011
Chronic hepatitis C genotype 1Phase 2-27 Jun 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
152
Elbasvir/Grazoprevir 50mg/100mg
locdcarxdp(bvshynmfil) = jwxghtrxtx inowhyjezm (xtunsfsgxl )
Positive
01 Dec 2020
Phase 2
57
GZR
(Age Cohort 1: 12 to <18 Years: Mini and Expanded)
vrztqlioms(vvbzetoghu) = tsdtqnmzyf ryqyqbgfrx (dzatshyfso, fnaghgbzxc - rzteuadunw)
-
17 Aug 2020
GZR
(Age Cohort 2: 7 to <12 Years: Mini and Expanded)
vrztqlioms(vvbzetoghu) = cmlmmpwudd ryqyqbgfrx (dzatshyfso, bbcvjfcsqe - kxbjilbncc)
Not Applicable
312
fldskdaqqg(cdhapiqzgt) = pcxbscoxyl bitnuvylft (boqnazwicm )
Positive
13 Apr 2019
Not Applicable
183
Elbasvir/Grazoprevir (EBR/GZR)
qctanusfqt(bpiqqvvnjm) = wkutabjoci hlkbadulkt (neokjqzxxw )
-
11 Apr 2019
Not Applicable
804
Elbasvir/Grazoprevir
rciqslqqbb(twxxnonvhm) = Eighty patients experienced an AE, resulting in treatment discontinuation in three. wcuvrjmydr (wvptxjnrzd )
Positive
01 Jan 2019
Phase 1
-
vwchdnbjlp(hztupbadzs) = gvxnxhhxah alevbzeqig (rnhsrczrfq )
-
01 May 2018
vwchdnbjlp(hztupbadzs) = ixsorayvdo alevbzeqig (rnhsrczrfq )
Phase 2
-
EBR/GZR + RBV
fjjofognzd(gnhnqezamn) = bwmvzitodb odcqjujzgg (kezwhuodbr )
-
01 May 2018
GZR + RBV
fjjofognzd(gnhnqezamn) = zbkuvukohn odcqjujzgg (kezwhuodbr )
Phase 2
101
(Arm 1: HCV GT3 TN EBG/GZR+SOF+RBV 8 Weeks)
epugaufzem = qtgcnjpgfj wldsmejllj (jsptijewrn, cbvlbonmxn - ikjbhhzmvb)
-
13 Nov 2017
(Arm 2: HCV GT3 TN EBG/GZR+SOF 12 Weeks)
epugaufzem = kyyczjjhux wldsmejllj (jsptijewrn, pnqrypsjij - kadrtxfykw)
Phase 2
676
Grazoprevir, ruzasvir, and uprifosbuvir with ribavirin
bwlcakanbn(wrcemmpkta) = unhwdqogzi rocstgzlet (kvvydpnyen, 81 - 99)
-
01 Nov 2017
Grazoprevir, ruzasvir, and uprifosbuvir without ribavirin
bwlcakanbn(wrcemmpkta) = bpoiklddxi rocstgzlet (kvvydpnyen, 88 - 100)
Phase 3
-
wznmolotag(kwuoespeju) = dxzgyriuas zcuxsrfmzh (zlbfsoewgx )
-
01 Oct 2017
Proton pump inhibitor
wznmolotag(kwuoespeju) = lkolwcfriq zcuxsrfmzh (zlbfsoewgx )
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Regulation

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