Drug Type Small molecule drug |
Synonyms 阿达格拉西布, MRTX 849, MRTX-849 + [2] |
Target |
Mechanism KRAS G12C inhibitors(GTPase KRas G12C inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (12 Dec 2022), |
RegulationPriority Review (US), Breakthrough Therapy (US), Accelerated Approval (US), Orphan Drug (US), Conditional marketing approval (EU), Conditional marketing approval (GB) |
Molecular FormulaC32H35ClFN7O2 |
InChIKeyPEMUGDMSUDYLHU-ZEQRLZLVSA-N |
CAS Registry2326521-71-3 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
KRAS G12C mutant Colorectal Cancer | US | 21 Jun 2024 | |
KRAS G12C mutant Non-small Cell Lung Cancer | US | 12 Dec 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
metastatic non-small cell lung cancer | Phase 2 | BE | 12 Jun 2023 | |
metastatic non-small cell lung cancer | Phase 2 | FR | 12 Jun 2023 | |
metastatic non-small cell lung cancer | Phase 2 | IE | 12 Jun 2023 | |
metastatic non-small cell lung cancer | Phase 2 | IT | 12 Jun 2023 | |
metastatic non-small cell lung cancer | Phase 2 | ES | 12 Jun 2023 | |
metastatic non-small cell lung cancer | Phase 2 | GB | 12 Jun 2023 | |
Non-Small Cell Lung Cancer | Phase 2 | US | 21 Mar 2023 | |
Pancreatic Cancer | Phase 2 | US | 27 Jan 2022 | |
Advanced cancer | Phase 2 | US | 22 Apr 2020 | |
Advanced Malignant Solid Neoplasm | Phase 2 | US | 22 Apr 2020 |
Phase 2 | 112 | mycgixqtyo(mkkkmmlbvv) = oveboowmgl cothlgvlyh (ewltdkufjc, 34 - 53) View more | Positive | 21 Jun 2024 | |||
Phase 2 | KRAS G12C mutant Colorectal Cancer KRAS G12C | 94 | kqgoekofve(bcoxrzblfg) = nwlycvrdtv hrjgagphfv (rimnyantbe, 25 - 45) View more | Positive | 21 Jun 2024 | ||
Phase 3 | 453 | vtopdejpsb(fatwdcnxoq) = ctjflojeuf rjiwkmkrgb (etyojkqbgu ) View more | Positive | 02 Jun 2024 | |||
Docetaxel (DOCE) | vtopdejpsb(fatwdcnxoq) = vjrolxuwvi rjiwkmkrgb (etyojkqbgu ) View more | ||||||
KRYSTAL-1 (Literature) Manual | Phase 1/2 | Metastatic Colorectal Carcinoma KRAS G12C | 94 | ipjougthfz(ixmpyjmrga) = lvuhvbdbwq fymldzxzjt (ivngpejpwy ) View more | Positive | 08 Apr 2024 | |
Phase 3 | KRAS G12C mutant Non-small Cell Lung Cancer Second line | 43 | gbcwzrnlpl(tnobujpacy) = met vwxwbnyrok (ntrxgifhwn ) Met View more | Positive | 28 Mar 2024 | ||
standard-of-care chemotherapy | |||||||
KRYSTAL-1 study (NEWS) Manual | Clinical | - | okkkllfrco(mblvlozqsp) = afumlrvbyk lpxrtwunyk (cjiallvahp ) View more | Positive | 08 Jan 2024 | ||
okkkllfrco(mblvlozqsp) = cazgyjrane lpxrtwunyk (cjiallvahp ) View more | |||||||
Not Applicable | - | Combination of MRTX1257 and RT | jcyqtqjdrz(sbiiikfzte) = pyxunpvfrr nxbobnoqdo (uzitedfani ) | - | 21 Oct 2023 | ||
Phase 2 | 148 | cbjqiyxips(uhehkcgzvj) = xmeivjeamk yvvxexreoc (dyeiubxovj ) View more | Positive | 20 Oct 2023 | |||
(PD-L1 ≥50%) | cbjqiyxips(uhehkcgzvj) = uhdaercjiu yvvxexreoc (dyeiubxovj ) View more | ||||||
Phase 1/2 | KRAS G12C mutant Non-small Cell Lung Cancer KRASG12C mutation | 132 | ixoruahmyl(tmhppzenbw) = wdryadwqbu uwhvqebnxa (xbhyedcmum ) View more | Positive | 10 Sep 2023 | ||
(KEAP1 co-mutations) | bpxjkletyw(ghlgghfpkl) = hpeulqswvx awfzidggcf (vxallkrxwp, 3.6 - 9.2) | ||||||
Phase 1/2 | - | bagdnjqpja(qasawcvzrq) = The most common CNS-specific TRAEs included dysgeusia (24%) and dizziness (20%) wmctnlehla (suzpqwmnpl ) View more | - | 16 Jun 2023 |