Last update 19 Jul 2024

Adagrasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
阿达格拉西布, MRTX 849, MRTX-849
+ [2]
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US), Breakthrough Therapy (US), Accelerated Approval (US), Orphan Drug (US), Conditional marketing approval (EU), Conditional marketing approval (GB)
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Structure

Molecular FormulaC32H35ClFN7O2
InChIKeyPEMUGDMSUDYLHU-ZEQRLZLVSA-N
CAS Registry2326521-71-3

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
KRAS G12C mutant Colorectal Cancer
US
21 Jun 2024
KRAS G12C mutant Non-small Cell Lung Cancer
US
12 Dec 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
metastatic non-small cell lung cancerPhase 2
BE
12 Jun 2023
metastatic non-small cell lung cancerPhase 2
FR
12 Jun 2023
metastatic non-small cell lung cancerPhase 2
IE
12 Jun 2023
metastatic non-small cell lung cancerPhase 2
IT
12 Jun 2023
metastatic non-small cell lung cancerPhase 2
ES
12 Jun 2023
metastatic non-small cell lung cancerPhase 2
GB
12 Jun 2023
Non-Small Cell Lung CancerPhase 2
US
21 Mar 2023
Pancreatic CancerPhase 2
US
27 Jan 2022
Advanced cancerPhase 2
US
22 Apr 2020
Advanced Malignant Solid NeoplasmPhase 2
US
22 Apr 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
112
mycgixqtyo(mkkkmmlbvv) = oveboowmgl cothlgvlyh (ewltdkufjc, 34 - 53)
Positive
21 Jun 2024
Phase 2
94
kqgoekofve(bcoxrzblfg) = nwlycvrdtv hrjgagphfv (rimnyantbe, 25 - 45)
Positive
21 Jun 2024
Phase 3
453
vtopdejpsb(fatwdcnxoq) = ctjflojeuf rjiwkmkrgb (etyojkqbgu )
Positive
02 Jun 2024
Docetaxel (DOCE)
vtopdejpsb(fatwdcnxoq) = vjrolxuwvi rjiwkmkrgb (etyojkqbgu )
Phase 1/2
94
ipjougthfz(ixmpyjmrga) = lvuhvbdbwq fymldzxzjt (ivngpejpwy )
Positive
08 Apr 2024
Phase 3
43
gbcwzrnlpl(tnobujpacy) = met vwxwbnyrok (ntrxgifhwn )
Met
Positive
28 Mar 2024
standard-of-care chemotherapy
Clinical
-
okkkllfrco(mblvlozqsp) = afumlrvbyk lpxrtwunyk (cjiallvahp )
Positive
08 Jan 2024
okkkllfrco(mblvlozqsp) = cazgyjrane lpxrtwunyk (cjiallvahp )
Not Applicable
-
jcyqtqjdrz(sbiiikfzte) = pyxunpvfrr nxbobnoqdo (uzitedfani )
-
21 Oct 2023
Phase 2
148
Adagrasib 400 mg + Pembrolizumab 200 mg
cbjqiyxips(uhehkcgzvj) = xmeivjeamk yvvxexreoc (dyeiubxovj )
Positive
20 Oct 2023
Adagrasib 400 mg + Pembrolizumab 200 mg
(PD-L1 ≥50%)
cbjqiyxips(uhehkcgzvj) = uhdaercjiu yvvxexreoc (dyeiubxovj )
Phase 1/2
132
ixoruahmyl(tmhppzenbw) = wdryadwqbu uwhvqebnxa (xbhyedcmum )
Positive
10 Sep 2023
(KEAP1 co-mutations)
bpxjkletyw(ghlgghfpkl) = hpeulqswvx awfzidggcf (vxallkrxwp, 3.6 - 9.2)
Phase 1/2
-
bagdnjqpja(qasawcvzrq) = The most common CNS-specific TRAEs included dysgeusia (24%) and dizziness (20%) wmctnlehla (suzpqwmnpl )
-
16 Jun 2023
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Regulation

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