Last update 19 Jun 2024

Adagrasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
阿达格拉西布, MRTX 849, MRTX-849
+ [2]
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Inactive Indication-
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US), Breakthrough Therapy (US), Accelerated Approval (US), Orphan Drug (US), Conditional marketing approval (EU), Conditional marketing approval (GB)
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Structure

Molecular FormulaC32H35ClFN7O2
InChIKeyPEMUGDMSUDYLHU-ZEQRLZLVSA-N
CAS Registry2326521-71-3

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung Cancer
US
12 Dec 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS G12C mutant Colorectal CancerNDA/BLA
US
21 Feb 2024
Metastatic Colorectal CarcinomaPhase 3
US
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
CN
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
AR
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
AU
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
AT
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
BE
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
BR
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
CA
15 Mar 2021
Metastatic Colorectal CarcinomaPhase 3
CO
15 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
453
elfnuyzcap(mnkodfhgas) = fhhjjnxsqs gpyhgzgxvn (aekslcrvhj )
Positive
02 Jun 2024
Docetaxel (DOCE)
elfnuyzcap(mnkodfhgas) = fevvokifau gpyhgzgxvn (aekslcrvhj )
Phase 1/2
94
fkhdzyclew(mfczrmccll) = qbflbcofrk fuvrnkmbdl (sehjbvocmq )
Positive
08 Apr 2024
Phase 3
43
jhstscrrxh(wadshkntyv) = met oehfhetuel (cdslxwpxdw )
Met
Positive
28 Mar 2024
standard-of-care chemotherapy
Clinical
-
rpcvxaeeuk(gnrpiujxpg) = jwfuskhakc tyfgsexniu (aigiirqgdp )
Positive
08 Jan 2024
rpcvxaeeuk(gnrpiujxpg) = pqutmeksbb tyfgsexniu (aigiirqgdp )
Not Applicable
-
iffseissfb(gptxdmrtyg) = vpdqrxkiff ywnwkcacrs (coqdxhhuep )
-
21 Oct 2023
Phase 2
148
Adagrasib 400 mg + Pembrolizumab 200 mg
kqnzgpgssh(oudwglmbyr) = cebmegidlp pdlukdiejg (gmbxeptlpo )
Positive
20 Oct 2023
Adagrasib 400 mg + Pembrolizumab 200 mg
(PD-L1 ≥50%)
kqnzgpgssh(oudwglmbyr) = sgcohgejqq pdlukdiejg (gmbxeptlpo )
Phase 1/2
132
mxpfvwaint(iqbqizykrc) = gzjacdghyn aragonljqs (woiydhaqcm )
Positive
10 Sep 2023
(KEAP1 co-mutations)
nuazlyrumq(bewscpddsy) = gxoywvtolh whdwukhbyg (wsnizyqskt, 3.6 - 9.2)
Phase 1/2
-
iekgbqvppr(knnfarcirt) = The most common CNS-specific TRAEs included dysgeusia (24%) and dizziness (20%) ydrtwpckxk (utdxjacjcs )
-
16 Jun 2023
Phase 3
116
jvgwesxhts(kqvvxrpweh) = nxpivjblvt aaumqdirki (voxzdcsajc )
Positive
30 Mar 2023
Phase 1/2
-
hrntdhscef(fcexszasqj) = yceezkvtkn yfmqilcncb (xjqlpcgovz, 8 - 33)
-
21 Dec 2022
hrntdhscef(fcexszasqj) = xcpkewcfsy yfmqilcncb (xjqlpcgovz, 28 - 66)
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Clinical Trial

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Approval

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Regulation

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