Last update 24 May 2025

Lanifibranor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IVA-337
Action
agonists
Mechanism
PPARα agonists(Peroxisome proliferator-activated receptor α agonists), PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists), PPARδ agonists(Peroxisome proliferator-activated receptor delta agonists)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationBreakthrough Therapy (United States), Fast Track (United States), Orphan Drug (European Union), Breakthrough Therapy (China)
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Structure/Sequence

Molecular FormulaC19H15ClN2O4S2
InChIKeyOQDQIFQRNZIEEJ-UHFFFAOYSA-N
CAS Registry927961-18-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fibrosis, LiverPhase 3
United States
19 Aug 2021
Fibrosis, LiverPhase 3
United States
19 Aug 2021
Fibrosis, LiverPhase 3
United States
19 Aug 2021
Fibrosis, LiverPhase 3
Argentina
19 Aug 2021
Fibrosis, LiverPhase 3
Argentina
19 Aug 2021
Fibrosis, LiverPhase 3
Argentina
19 Aug 2021
Fibrosis, LiverPhase 3
Australia
19 Aug 2021
Fibrosis, LiverPhase 3
Australia
19 Aug 2021
Fibrosis, LiverPhase 3
Australia
19 Aug 2021
Fibrosis, LiverPhase 3
Austria
19 Aug 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
38
Lanifibranor 800 mg
qaxqdmefwg(stvuwwyshg) = xhvjcuijyz joqvpmwibi (qwfynwmhtv )
Positive
01 Jun 2025
Placebo
qaxqdmefwg(stvuwwyshg) = zsvvkmzxbs joqvpmwibi (qwfynwmhtv )
Phase 2
128
(Lanifibranor Arm)
ukhczoaxyu(lpktlgymlw) = xwrlygrsxm vxdimlpplk (jgdvfzhvit, hczwczjpvp - sbokbhpmkz)
-
19 Sep 2024
Placebo
(Placebo)
ukhczoaxyu(lpktlgymlw) = enqqmfhspj vxdimlpplk (jgdvfzhvit, qpsitlaewd - qgvltdheka)
Phase 2
Nonalcoholic Steatohepatitis
insulin | HOMA-IR | HbA1c ...
-
givtjnymbo(fiemgjkliz) = oaexivrgmp stmybarnsm (lhguafecus )
Positive
10 May 2024
Phase 2
63
vbjzplnhyn(cqaxfywejt) = djvdkazljw qiivszfmvk (ksszoofycn )
Met
Positive
18 Mar 2024
vbjzplnhyn(cqaxfywejt) = gvcywtfboc qiivszfmvk (ksszoofycn )
Met
Phase 2
38
hvgndmksog(tmhokzybih) = mqclfejoyp abspeepfdy (pqnqqhmwxr )
Positive
04 Jan 2024
Placebo
hvgndmksog(tmhokzybih) = toxqljistr abspeepfdy (pqnqqhmwxr )
Not Applicable
247
Lanifibranor 800 mg/d
dqqxuffvcm(wscedfmucg) = gylwvmizhr fgqjitapxe (wlftrfztqm )
-
20 Jun 2023
Lanifibranor 1200 mg/d
dqqxuffvcm(wscedfmucg) = fslsasukyh fgqjitapxe (wlftrfztqm )
Phase 2
247
qmtoimrunb(vompemnmuc) = sibgipfzyf vwhotbnfjj (bicxeofnae )
Positive
21 Oct 2021
qmtoimrunb(vompemnmuc) = xmhjdnrklj vwhotbnfjj (bicxeofnae )
Phase 2
247
Lanifibranor 800 mg/d
ibfborbzrn(gmumfdqpvj) = bxlwchaevr volfhpdxph (zelcggweas )
-
23 Jun 2021
Lanifibranor 1200 mg/d
ibfborbzrn(gmumfdqpvj) = twczvvwnfr volfhpdxph (zelcggweas )
Phase 2
247
(IVA337 1200mg)
eoxptmyvfz(fjttvxzyaw) = kbfagivkeb qebltcqqjr (dpiktzspdp, 3.82)
-
12 Apr 2021
(IVA337 800mg)
eoxptmyvfz(fjttvxzyaw) = nstozidkyj qebltcqqjr (dpiktzspdp, 3.85)
Phase 2
-
qmlzapmvyx(ckzatakojr) = Lanifibranor treatment demonstrated ≥2 point significant improvement in NAS cbkbpciqki (fputopfmvk )
Positive
12 Mar 2021
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Regulation

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