Gilead Sciences Shanghai Pharmaceutical Technology Co. Ltd.

Primary objectives: 1. Compare the effects of SG and TPC on PFS assessed by BICR; 2. Compare the effects of SG and TPC on OS Key secondary objectives: 1. Compare the effects of SG and TPC on ORR assessed by BICR; 2. Compare the effects of SG and TPC on physical function Secondary objectives: 1. Compare the effects of SG and TPC on the following indicators: PFS assessed by investigators ORR assessed by investigators BICR and DOR assessed by investigators BICR and CBR assessed by investigators 2. Evaluate the safety and tolerability of SG compared with TPC 3. Compare the effects of SG and TPC on GHS/QoL Exploratory objectives: 1. Evaluate the expression status of trophoblast cell surface antigen 2 (Trop-2) in tumors as a potential predictive biomarker for the efficacy of SG 2. Evaluate the relationship between tumor MMR/MSI status and clinical remission or treatment resistance 3. Explore blood and tumor biomarkers that can predict clinical response or treatment resistance 4. Characterize the pharmacokinetics (PK) and immunogenicity of SG 5. Further characterize health-related QoL

To evaluate the efficacy and safety of liposomal amphotericin B for injection (trademark: Amphotericin B®) in Chinese adults and pediatric patients aged 1 month to 18 years.

Objective 1: To record the number of people who use PrEP once a day among 3,200 high-risk MSM and college-age youth in two Chinese cities. Objective 2: To obtain HIV/STI risk behaviors and knowledge, perceptions, and practices regarding sexual behaviors and PrEP use through questionnaire surveys among 3,200 high-risk MSM and college-age youth in two Chinese cities. Objective 3: To obtain data on syphilis and HIV prevalence among 3,200 MSM and college-age youth and syphilis, gonorrhea, chlamydia, and HIV prevalence among 1,200 PrEP users in two Chinese cities. Objective 4: To determine retention, adherence, and characteristics of 1,200 PrEP users at 6 and 12 months. Objective 5: To evaluate the experience of the PrEP WeChat mini-program intervention among MSM and college-age youth through in-depth interviews with selected participants (n = 30).