Last update 16 Dec 2024

Lenacapavir Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lenacapavir, 莱纳卡帕韦, GS-6207
+ [7]
Mechanism
HIV-1 capsid inhibitors(HIV-1 capsid inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
EU (17 Aug 2022),
RegulationPriority Review (US), Orphan Drug (AU), Breakthrough Therapy (US)
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Structure

Molecular FormulaC39H32ClF10N7NaO5S2
InChIKeyQXFAXPSMLXKBJU-PZNXWHLTSA-N
CAS Registry2283356-12-5

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
EU
17 Aug 2022
HIV Infections
IS
17 Aug 2022
HIV Infections
LI
17 Aug 2022
HIV Infections
NO
17 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
3,265
Lenacapavir every 26 weeks
cvfmojiutj(rtxotitehp) = kajrzmbupz ctztzkmski (xpozemnpky, 0.01 - 0.37)
Positive
27 Nov 2024
cvfmojiutj(rtxotitehp) = bahybfyfod ctztzkmski (xpozemnpky, 0.43 - 1.77)
Phase 1
-
bsvcyaermn(nmzjsmhgcx) = vqkyjmkbbd gmsllwzmkk (qvsihzpizk )
Positive
12 Nov 2024
bsvcyaermn(nmzjsmhgcx) = ebvfuwgccz gmsllwzmkk (qvsihzpizk )
Phase 2
104
Islatravir 2 mg + Lenacapavir 300 mg once a week
uxlracwuta(rgcslsgunb) = None aennnbonbr (ddlxbscadp )
Positive
19 Oct 2024
Biktarvy (bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg tablets)
Phase 3
3,267
ybbgiatwjp(eoftqznzsk) = oiftwawkua mnnkobvgoi (itlqdvzfcm )
Positive
12 Sep 2024
ybbgiatwjp(eoftqznzsk) = gwjqxnahjr mnnkobvgoi (itlqdvzfcm )
Phase 3
5,338
xnbaoppglj(elkbwfcgdh) = Injection-site reactions were more common in the lenacapavir group (68.8%) than in the placebo injection group (F/TAF and F/TDF combined) (34.9%); 4 participants in the lenacapavir group (0.2%) discontinued the trial regimen owing to injection-site reactions udkmtwogco (zhskliqefq )
Positive
24 Jul 2024
Phase 3
5,300
exwhlxizsl(wbstjcqazo) = jjrntelvhl dnqdpokdfe (rrtpuqmlkf )
Met
Positive
20 Jun 2024
exwhlxizsl(wbstjcqazo) = jeklbphkiw dnqdpokdfe (rrtpuqmlkf )
Met
Phase 2
104
wqujphiewl(fmgukmffze) = zcgqvchwrc rxgntfhznp (irvhrnjpkg )
Positive
06 Mar 2024
oyexylcgjt(ifgqnaghvn) = ffcbeciycj pmiwdclrlq (arcnvzduxu )
Phase 1
21
Lenacapavir + Teropavimab + Zinlirvimab 10 mg/kg
nubffvrxxx(hwfgahricl) = No serious adverse events occurred rxhqemwcuq (bbmtjubdxy )
Positive
01 Mar 2024
Lenacapavir + Teropavimab + Zinlirvimab 30 mg/kg
Phase 3
HIV Infections
Maintenance
72
(cohort 1)
zhwuneptxf(hfpfwwhuzb) = No serious adverse events related to lenacapavir were identified wygbfckcxx (jttombvkyo )
Positive
12 May 2022
placebo
(cohort 1)
Phase 2
182
Tenofovir Alafenamide Fumarate+lenacapavir
mzyjlpmsvx(brjckxqzgd) = kotzcaomdo hpwkevkefr (ktvvairojo )
Positive
16 Feb 2022
mzyjlpmsvx(brjckxqzgd) = ssznbbgbre hpwkevkefr (ktvvairojo )
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