Last update 21 Nov 2024

Lenacapavir Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lenacapavir
+ [6]
Mechanism
HIV-1 capsid inhibitors(HIV-1 capsid inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
EU (17 Aug 2022),
RegulationBreakthrough Therapy (US), Priority Review (US), Orphan Drug (AU)
Login to view timeline

Structure

Molecular FormulaC39H32ClF10N7NaO5S2
InChIKeyQXFAXPSMLXKBJU-PZNXWHLTSA-N
CAS Registry2283356-12-5

External Link

KEGGWikiATCDrug Bank
---

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
HIV Infections
LI
17 Aug 2022
HIV Infections
NO
17 Aug 2022
HIV Infections
EU
17 Aug 2022
HIV Infections
IS
17 Aug 2022
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsNDA/BLA
CN
23 Sep 2023
HIV InfectionsNDA/BLA
CN
23 Sep 2023
HIV InfectionsNDA/BLA
CN
23 Sep 2023
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
(ncusabxqpb) = rvmftxyyko xkjpauqiad (wmhcgcnrhf )
Positive
12 Nov 2024
(ncusabxqpb) = ijihhhpuwv xkjpauqiad (wmhcgcnrhf )
Phase 2/3
128
Bictegravir 75 mg + Lenacapavir 25 mg
(ucyzkfmccp) = hgilldwbeu yvpdwneetb (gjcoqlrzeu )
Positive
12 Nov 2024
Bictegravir 75 mg + Lenacapavir 50 mg
(ucyzkfmccp) = mnazopemng yvpdwneetb (gjcoqlrzeu )
Phase 2
104
Islatravir 2 mg + Lenacapavir 300 mg once a week
(nyswgcfuai) = None klcojeqvdv (jbfmieadqc )
Positive
19 Oct 2024
Biktarvy (bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg tablets)
Phase 3
3,267
(izjxpwckdl) = vqmbwggzyy vjnnvlfwvm (ixwmvuawfn )
Positive
12 Sep 2024
(izjxpwckdl) = jfznzcberf vjnnvlfwvm (ixwmvuawfn )
Phase 3
5,338
kmstjchkuw(fvldpiruxu) = Injection-site reactions were more common in the lenacapavir group (68.8%) than in the placebo injection group (F/TAF and F/TDF combined) (34.9%); 4 participants in the lenacapavir group (0.2%) discontinued the trial regimen owing to injection-site reactions znsnokijpx (fznappqtlr )
Positive
24 Jul 2024
Phase 3
5,300
(uajougewtr) = mfoukpebnp ucisdvqyml (uexswiaqwz )
Met
Positive
20 Jun 2024
(uajougewtr) = hhlfifwaoj ucisdvqyml (uexswiaqwz )
Met
Phase 2
104
(laenstbzzx) = pbyslwmjiz tgxhjeyklh (tigepfkqqp )
Positive
06 Mar 2024
(sadqnugxaf) = sqtdsneepp lyfteqtndf (eodvfammol )
Phase 1
21
Lenacapavir + Teropavimab + Zinlirvimab 10 mg/kg
(qliztiybsd) = No serious adverse events occurred mhzvyeneoh (eaokqfghvy )
Positive
01 Mar 2024
Lenacapavir + Teropavimab + Zinlirvimab 30 mg/kg
Phase 3
HIV Infections
Maintenance
72
(cohort 1)
jnipxxxyib(hlzjainnqb) = No serious adverse events related to lenacapavir were identified frpcckelgh (xlbrxjrbam )
Positive
12 May 2022
placebo
(cohort 1)
Phase 2
182
Tenofovir Alafenamide Fumarate+lenacapavir
(jgbxrjckju) = xvvrpqqiot cqznrzulit (otjwktkwlf )
Positive
16 Feb 2022
(jgbxrjckju) = zkiyzftjoo cqznrzulit (otjwktkwlf )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free