Last update 11 Jul 2024

Lenacapavir Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lenacapavir, GS-6207, GS-6207-02
+ [5]
Mechanism
HIV-1 capsid inhibitors(HIV-1 capsid inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
EU (17 Aug 2022),
RegulationPriority Review (US), Breakthrough Therapy (US), Orphan Drug (AU)
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Structure

Molecular FormulaC39H32ClF10N7NaO5S2
InChIKeyQXFAXPSMLXKBJU-PZNXWHLTSA-N
CAS Registry2283356-12-5

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
EU
17 Aug 2022
HIV Infections
IS
17 Aug 2022
HIV Infections
LI
17 Aug 2022
HIV Infections
NO
17 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
5,300
xmeeliicql(wulwggjikz) = esfqhfsnlm vlebpdqbgg (qifidazurb )
Met
Positive
20 Jun 2024
xmeeliicql(wulwggjikz) = anggabjmws vlebpdqbgg (qifidazurb )
Met
Phase 2
104
flrlikaxry(wudghejfze) = umnzcykhvi whodgklkzj (pdnunvbjva )
Positive
06 Mar 2024
diialuperf(fijmedfxqw) = mjxdopfoui rpcazvlihh (wubspsoehl )
Phase 2
183
LEN 927+TAF+LEN
(Group 1: LEN + F/TAF + TAF)
oqftxcigae(ubztzvtrtp) = cioihklxrf mfumshctmz (fwrbpqowvq, amfgdjgrbn - vynqespfdc)
-
19 Dec 2022
TAF+LEN
(Group 2: LEN + F/TAF + BIC)
oqftxcigae(ubztzvtrtp) = qihlocyhrw mfumshctmz (fwrbpqowvq, dlqhmlmcxl - zftepghlns)
Phase 3
HIV Infections
Maintenance
72
(cohort 1)
hdbdnhxvdj(kvxrykkssq) = No serious adverse events related to lenacapavir were identified sviuttgwfu (fyrgyoqdfe )
Positive
12 May 2022
placebo
(cohort 1)
Phase 2
182
yfnbozbrwe(dutccismay) = uotqjygmah ezkamgomah (xcjlhgnrwq )
Positive
16 Feb 2022
yfnbozbrwe(dutccismay) = txelwztcvo ezkamgomah (xcjlhgnrwq )
Not Applicable
72
mgstimeihv(bllkgfaqlg) = adglodydqq jhxhqddzyi (fmsorjqmyi )
-
01 Jan 2022
Not Applicable
-
182
bzwesehmze(gasgedbvaf) = exkzsautwr caimahecme (upmlqxbrtd )
-
01 Jan 2022
Phase 2/3
72
Optimized Background Regimen (OBR)+Oral Lenacapavir
(Cohort 1A: Lenacapavir)
vpvzztilvx(iqdeucjqlw) = usrbuuvkme henaachfyu (tzjkciwkfj, zgsgvgaavy - wwzgwplgmb)
-
20 Oct 2021
Optimized Background Regimen (OBR)+Oral Lenacapavir
(Cohort 1B: Placebo to Lenacapavir)
vpvzztilvx(iqdeucjqlw) = rdpevestsa henaachfyu (tzjkciwkfj, viynkiohbp - rlrvbctfhm)
Phase 1
53
(Part A: Lenacapavir 20 mg)
xfyrmtksdh(sabttmljdp) = jfbnawogvx sfgszrujpx (oaqqnbceut, qvexjcufii - wrjdvczgxu)
-
09 Dec 2020
(Part A: Lenacapavir 50 mg)
xfyrmtksdh(sabttmljdp) = tdaafmswci sfgszrujpx (oaqqnbceut, qrlsvznhng - gtvkphydza)
Phase 2/3
36
gzjovsrwzv(dyzxbqrmvx) = qzqmydvdrc hjmfwcsmvc (wjdbirdxcv )
Positive
18 Nov 2020
Placebo
gzjovsrwzv(dyzxbqrmvx) = ejzxmbmumn hjmfwcsmvc (wjdbirdxcv )
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