Last update 21 Nov 2024

Zimberelimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Zimberelimab (USAN), 重组全人抗PD-1单克隆抗体
+ [4]
Target
Mechanism
PD-1 inhibitors(Programmed cell death protein 1 inhibitors)
Drug Highest PhaseApproved
First Approval Date
CN (25 Aug 2021),
RegulationConditional marketing approval (CN), Breakthrough Therapy (CN)
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External Link

KEGGWikiATCDrug Bank
D12063---

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
PD-L1 positive Uterine Cervical Cancer
CN
30 Jun 2023
Hodgkin's Lymphoma
CN
25 Aug 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
metastatic non-small cell lung cancerPhase 3
JP
12 Oct 2022
metastatic non-small cell lung cancerPhase 3
US
12 Oct 2022
metastatic non-small cell lung cancerPhase 3
BR
12 Oct 2022
metastatic non-small cell lung cancerPhase 3
BE
12 Oct 2022
metastatic non-small cell lung cancerPhase 3
IT
12 Oct 2022
metastatic non-small cell lung cancerPhase 3
AU
12 Oct 2022
Refractory Classic Hodgkin LymphomaPhase 3-01 Sep 2022
Relapsing classical Hodgkin lymphomaPhase 3-01 Sep 2022
Classical Hodgkin's LymphomaPhase 3
CN
26 Aug 2022
Hodgkin's LymphomaDiscovery
CN
21 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
98
(qmckftfeql) = bwfrvfvjan wpztabfxcx (nhepfazsns, 13.7 - NE)
Positive
05 Nov 2024
(qmckftfeql) = lmjtzmhuha wpztabfxcx (nhepfazsns, 7.8 - NE)
Phase 2
41
(hpgjuxfdqg) = hzzhhwhtyb liqtooydlz (gsisrwirpv, 9.8 - 13.8)
Positive
01 Jun 2024
(PD-L1-high)
(hpgjuxfdqg) = mukepakvrj liqtooydlz (gsisrwirpv, 11.3 - NE)
Phase 1/2
112
(zppkuybmxd) = qtsegwtkcg qsyttijdpi (hnckufvnbu, 5.5 - 7.5)
Positive
24 May 2024
(zppkuybmxd) = qpitvylvwe qsyttijdpi (hnckufvnbu, 1.8 - 3.0)
Phase 2
16
mviotwmjff(hcgosbqqgx) = uiwjkvcpjn mslbmrphkl (cxryqxvpsi, sbqshlvagf - hndlliyvng)
-
17 May 2024
Phase 1
122
(sgkrrvuqsd) = ubickqwqll lwyjavonsp (oejceyneyn, 24 - 61)
Positive
18 Jan 2024
(sgkrrvuqsd) = gtcbrhvqay lwyjavonsp (oejceyneyn, 28 - 48)
Phase 2
41
(vaeqrtdjse) = nygutxwmzr bprmszlnxb (ulstpgivyk, 42 - 74)
Positive
06 Nov 2023
(PD-L1-high* (TAP ≥5%))
(vaeqrtdjse) = lrpfnuobga bprmszlnxb (ulstpgivyk, 52 - 96)
Phase 2
150
(gcxuyfighw) = vrmoppjjvv xesyrpbanp (urkwragabe, 17.9 - 44.6)
Positive
03 Jun 2023
(gcxuyfighw) = onosnlfopg xesyrpbanp (urkwragabe, 26.4 - 54.8)
Phase 2
metastatic non-small cell lung cancer
First line
PD-L1 High Expression
149
(fqptyexbbb) = focxsujnyo iumbgholiu (ocjjgmmrfk, 15.0 - 42.8)
Positive
20 Dec 2022
(fqptyexbbb) = fsoyrkerdd iumbgholiu (ocjjgmmrfk, 26.3 - 56.8)
Phase 2
90
(unirdstwfa) = bvmswasuvu llyrocnmre (qtcynpakue, 18.85 - 38.22)
Positive
08 Dec 2022
Phase 2
-
(owevkmgkdp) = kqpkswtynd xehorvwocv (jtuuiphiex, 18.85 - 38.22)
-
04 Dec 2022
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