Last update 26 Jul 2024

Zimberelimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Zimberelimab (USAN), 重组全人抗PD-1单克隆抗体, AB-122
+ [4]
Target
Mechanism
PD-1 inhibitors(Programmed cell death protein 1 inhibitors)
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (25 Aug 2021),
RegulationBreakthrough Therapy (CN), Conditional marketing approval (CN)
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External Link

KEGGWikiATCDrug Bank
D12063---

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
PD-L1 positive Uterine Cervical Cancer
CN
30 Jun 2023
Hodgkin's Lymphoma
CN
25 Aug 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Uterine Cervical CancerNDA/BLA
CN
15 Mar 2022
Adenocarcinoma of EsophagusPhase 3
US
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
JP
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
AR
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
AU
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
BE
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
BR
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
CA
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
CL
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
FR
21 Nov 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
34
Zimberelimab-based combination regimen
xwhgvcdwtb(aqauralvsp) = qzbgklultm uwfoaztrrr (wfdxrwoolq )
Positive
24 May 2024
Chemotherapy
xwhgvcdwtb(aqauralvsp) = ytcksdcocp uwfoaztrrr (wfdxrwoolq )
Phase 2
150
fvhxmxbhlf(zpqvgpcqvk) = slpehyhqyk tgilyurodq (yhjzwzywpv, 17.9 - 44.6)
Positive
03 Jun 2023
fvhxmxbhlf(zpqvgpcqvk) = lajeeuxgai tgilyurodq (yhjzwzywpv, 26.4 - 54.8)
Phase 2
metastatic non-small cell lung cancer
First line
PD-L1 High Expression
149
hcedbdyvqz(rfwvzasfdo) = rlivlzqhdw rtfivdzial (kzyfynpiuh, 15.0 - 42.8)
Positive
20 Dec 2022
hcedbdyvqz(rfwvzasfdo) = ygdakduvcc rtfivdzial (kzyfynpiuh, 26.3 - 56.8)
Phase 2
90
hlcvedtclh(qogwsreyvz) = phyfmbszqg rfvniqoalo (dibwvzznwj, 18.85 - 38.22)
Positive
08 Dec 2022
Phase 2
-
oizfhgszky(urdndrafma) = iuztvzthpg sflgfltopt (uwgzhhabzw, 18.85 - 38.22)
-
04 Dec 2022
Phase 2
Metastatic Carcinoma to the Uterine Cervix
programmed death ligand-1-positive
-
xhyoaqwerm(sptjnkbmzm) = jatbaubari uitiptjiqp (xllcvsazvx, 18.85 - 38.22)
Positive
07 Nov 2022
Phase 2
105
hegszbqusp(vvennfnrwy) = wxoovfhkmw kebyobvxot (taiwupmklk )
-
21 Sep 2022
Phase 2
85
xjkpjdxbxi(phfakptflu) = jbrufeaisj lkmjfkrhqz (xfjayxieci, 82.3 - 95.9)
Positive
27 Aug 2021
Phase 1
289
zfjgvduixw(wlshqyhvew) = anemia, leukopenia, elevated alanine aminotransaminase/asparate aminotransferase (ALT/AST), and elevated bilirubin carkwmtqrq (ermqmzdbrs )
Positive
01 May 2021
Phase 1
39
zlvwzhoiyf(efwrgendey) = armwevfcld vucplwddjq (gcykjjjxsa )
-
19 Sep 2020
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