Hebei Chuangjian Pharmaceutical Co., Ltd

The main purpose of the study is to study the pharmacokinetics of beclomethasone dipropionate suspension for inhalation (specification: 2 ml: 0.8 mg; trade name: Baoliya®) held by Hebei Chuangjian Pharmaceutical Co., Ltd. in healthy subjects under fasting conditions, using the beclomethasone dipropionate suspension for inhalation (specification: 2 ml: 0.8 mg; trade name: Baoliya®) held by Chiesi Farmaceutici S.p.A. as the reference preparation, and evaluate whether the test preparation and the reference preparation are bioequivalent. Secondary purpose of the study: to observe the safety of the test preparation and the reference preparation in healthy subjects.

The bioequivalence of the test preparation and the reference preparation was evaluated in healthy subjects under fasting and fed conditions. The safety of the test preparation, Cinacalcet Hydrochloride Tablets, and the reference preparation in healthy subjects was observed.

After healthy subjects took a single dose of olopatadine hydrochloride tablets (test preparation, developed by Hebei Chuangjian Pharmaceutical Co., Ltd.) and the original drug, olopatadine hydrochloride tablets (trade name: Aloka; reference preparation, produced by Kyowa Hakko Kirin Co., Ltd. Fuji Plant) orally on an empty stomach or after a meal, the concentration of olopatadine in plasma was measured, the absorption rate and extent of the test preparation and the reference preparation were studied, and whether the test preparation and the reference preparation were bioequivalent was evaluated.