Hunan Dongting Pharmaceutical Co., Ltd.

Objective To establish a derivative gas chromatog. method simultaneously quant. determination of Me methanesulfonate(MMS), Et methanesulfonate(EMS),isopropyl methanesulfonate(IMS) in escitalopram oxalate. ethods: NaI-H2 O solution as the iodonation agent,DB-WAX(30 m*0.45 mm, 85 um) capillary column was used to sep. the fatty acids and FID for quant. determination esults: The linear range of Me iodide is 0.2784∼10.44 μg/mL the linear range of Iodoethane is 0.2944∼11.04 μg/mL the linear range of 2-iodopropane is 0.2608∼9.78 μg/mL.The method's specificity and accuracy meet the requirements.Conclusion: The method shows satisfactory repeatability, simplicity and convenience, and is valid in simultaneous derivation separation and anal. of these methanesulfonic acid alkyl ester in escitalopram oxalate.

CASS process was first used in pharmaceutical wastewater treatment system.Due to the insufficient design of raw water, aeration system and process design, the effluent COD has not reached the design target since the system was put into operation.The original CASS process was changed to A/O process.Aiming at the problem of insufficient aeration capacity of A/O system, the original membrane aeration was changed to jet aeration.The oxygen transfer rate was greatly improved, COD and ammonia nitrogen were reduced to below the standard, and the emission was up to standard

Deactivation palladium carbon was used 2N hydrochloric acid and methanol.Palladium carbon can be used for 300 times.The method can be used in production of cetraxate hydrochloride.