→ As
 bluebird bio
’s regulatory concerns swell yet again by pressing the pause button for 
LentiGlobin
 a month ago, 
Joanne Smith-Farrell
 won’t be around to see how the saga plays out with the FDA. Smith-Farrell 
has taken the helm
 at 
Longwood
-backed B cell biotech
 Be Biopharma
, which launched last October with a $52 million Series A 
round
. She was previously bluebird’s COO and business unit head, oncology, and she first came to 
Nick Leschly
’s team as CBO in 2017 after her Big Pharma experience in business development with 
Merck
 and 
Pfizer
. Smith-Farrell 
tells
 our Kyle Blankenship that her decision to become CEO at Be Bio wasn’t related to the decision to 
split
 bluebird into two companies in January.
Elsewhere, 
Rick Morgan
 has decided not to be 
part
 of the 
Jim Mullen
 Experience at 
Editas Medicine
 after joining Be Bio as CSO. Morgan, a bluebird vet in his own right, had been the SVP of immunogenetics at Editas since 2018.
→ Smith-Farrell isn’t the only bluebird staffer that’s getting out of Dodge. CMO 
David Davidson
announced
 his intent to leave bluebird after nine years on the job, effective April 16. The 
Genzyme
 vet will stay on as a consultant until his successor is found. While the sun parted from the clouds for bluebird this week with positive 
data
 for its Lorenzo’s Oil disease program, the LentiGlobin 
drama
 and the 
suspension
 of marketing for 
Zynteglo
 still represent a stormy pattern at the biotech.
→
 Roger Perlmutter
 sure initiated a changing of the guard at Merck. After the R&D chief 
announced
 he would hang it up, CEO 
Ken Frazier
 followed suit by 
planning
 a June 30 departure. 
Mike Nally
, chief marketing officer for the Human Health division, was on an internal short list of candidates to replace Frazier. But with 
Robert Davis
 waiting in the wings as CEO, Nally is 
on his way out
 too after holding numerous gigs at the pharma giant since 2003 before becoming the chief marketing exec two years ago. 
Frank Clyburn
, who joined Merck in 2008 and was chief commercial officer, Human Health, 
has been given
 the title of president, Human Health.
One other 
note
 on Perlmutter: Shanghai-based CBC Group 
just named him
 as a science partner and a member of the scientific advisory board.
→ Juxtaposed with the positive Phase III data that were released in the SHORELINE study for depression drug 
zuranolone
, 
Sage
 COO 
Mike Cloonan
 wants to set out on his own as a CEO (destination unknown) and 
bids adieu
 on May 3. The MOUNTAIN study for 
zuranolone
failed
 in late 2019, gutting the stock. And Cloonan, an ex-
Biogen
 commercial exec who began as Sage’s CBO in 2017, transitioned to COO after a 
restructuring
 that resulted in more than half the workforce facing the chopping block in April 2020. Three months ago, 
Barry Greene
stepped in
 to helm Sage, while ex-CEO 
Jeff Jonas
 took over as chief information officer.
→ 
Frank Zhang
 was 
released
 on bail last month, but he’s a man without a company now that 
Ying Huang
 has taken over as 
Legend
’s CEO, and the Chinese biotech continues life after Zhang with 
Lori Macomber
getting promoted
 to VP, finance. Since 2019, Macomber had been Legend’s VP of supply chain finance and controller, and she also brings seven years of financial experience from 
Eli Lilly
. The move comes two months after Legend made 
Lida Pacaud
 VP of clinical development after wrapping up her tenure at 
Novartis Oncology
 as global program clinical head, executive medical director of the cell & gene therapy unit.
→ Co-founded by 
David Liu
 and fresh off the 
acquisition
 of Georgia Tech spinout 
Guide Therapeutics
, base editing biotech 
Beam Therapeutics
has named
Amy Simon
 CMO. Simon had been with 
Alnylam
 since 2010, starting as a clinical researcher and then moving up to VP of clinical development, a title she had held for the past year. She was the lead clinician for 
givosiran
, marketed as 
Givlaari
 after the FDA 
approved
 the drug in 2019 for acute hepatic porphyria.
→ Former 
Five Prime Therapeutics
 president and CEO 
Aron Knickerbocker
has taken
 the helm of 
Aulos Bioscience
 as CEO. Prior to his new role, Knickerbocker was co-founder, founding CEO and chairman of 
RayzeBio
. Prior to RayzeBio and Five Prime, Knickerbocker spent over eight years at 
Genentech
.
→
 Chris Garabedian
’s Perceptive Xontogeny Fund 
led the way
 on the Series A last summer, and now 
Steve Altschuler
-chaired eye disease biotech 
AsclepiX
 out of Baltimore 
has handed
 the president and CEO reins to 
Robert Dempsey
. 
Bellicum
 founder 
Kevin Slawin
 had been interim CEO before the appointment. Dempsey, who had helmed ophthalmic company 
TearClear
, was global head of ophthalmology at 
Shire
 and was at the forefront of 
Takeda
’s 2019 sale of 
Xiidra
 to 
Novartis
 in an up to $5.3 billion deal.
→ Shire alum 
Mark Rus
has become
 CEO of Boston-based 
Delix Therapeutics
, which is aimed at CNS disorders and uses technology from 
David Olson
’s lab at UC-Davis to develop “psychoplastogens,” or molecules that can promote neuroplasticity. Rus just served as an entrepreneur-in-residence and advisor for 
Atlas Venture
 and logged 13 years at Shire until the Takeda buyout, the last four of those years as group VP of neuroscience.
→ 
Nordic Nanovector
has reeled in
Peter Braun
 as CEO. Braun joins the company with three decades of experience from 
Roche
, where he served as SVP, head of access strategy, health policy & communications. In addition to Roche, Braun served at 
Biofourmis
 as CCO.
→ There’s a new sheriff in town at Swedish immuno-oncology outfit 
Alligator Bioscience
, with 
Søren Bregenholt
taking command
 as CEO after helming UK-based 
Macrophage Pharma
 since 2019. Prior to his first CEO job, Bregenholt held corporate VP posts for eight years each at 
Novo Nordisk
 and 
Symphogen
. Bregenholt succeeds 
Per Norlén
 starting June 1, and in the meantime, COO 
Malin Carlsson
 will fill the interim CEO slot.
→ Belgium-based 
Augustine Therapeutics
has selected
Sylvain Celanire
 as its CEO. Celanire jumpstarted his career at 
UCB New Medicine
 before hopping aboard 
Addex Therapeutics
. In addition, Celanire is the co-founder and CEO of 
Pragma Therapeutics
.
→ 
Yi Larson
has joined
Perceptive
 startup 
LianBio
, a “best-in-class sourcing and development engine” in China that 
launched
 last August, as CFO. A former managing director of healthcare investment banking at 
Goldman Sachs
, Larson just completed her first turn as a CFO with 
Turning Point Therapeutics
. A few months after contributing to LianBio’s debut round, Pfizer 
forked over
 an additional $70 million in a collaboration built around in-licensing and co-developing new therapies.
→ While the country fills out NCAA Tournament brackets, 
Eledon Pharmaceuticals
is filling out
 its leadership team with 
Jeff Bornstein
 as CMO and 
Paul Little
 as CFO. Bornstein, a Biogen and 
Gilead
 alum, comes to Eledon from Takeda, where he was the Japanese pharma’s VP and head of clinical sciences, gastroenterology. Little is a longtime 
Allergan
 exec in finance and commercial operations who had previously been CFO and treasurer of 
Sientra
. Eledon, a biotech out of Irvine, CA, targets the CD40L pathway to develop drugs for those with ALS, autoimmune diseases and organ or cell transplant recipients.
→ Pittsburgh-based biotech 
Peptilogics
, which focuses on peptide drug design and development — and scored a $35.4 million Series B that was 
boosted
 by 
Peter Thiel
 — 
has tapped
David Huang
 as SVP and CMO. Huang is a longtime attending physician with the Department of Veterans Affairs and has been a CMO before with 
ContraFect
, 
Motif Bio
, and
 X-Biotix Pharmaceuticals
.
Peptilogics has made a couple other appointments with 
Nick Nystrom
 as SVP, computing and data, and 
Nicholas Pachuda
 as SVP, portfolio strategy and development. Nystrom spent 28 years with the 
Pittsburgh Supercomputing Center
, departing as chief scientist, while Pachuda hails from
 J&J
’s orthopedic franchise,
 DePuy Synthes
, serving as worldwide VP of external innovation and enabling technologies.
→ 
Christopher Recknor
is getting promoted
 to COO at 
CytoDyn
, a week after CEO 
Nader Pourhassan
 cranked up the spin machine 
to explain
 how 
leronlimab
 missing the mark on its primary endpoint was a source of optimism. Recknor, who joined CytoDyn as VP of clinical development in August 2020, has also been a principal investigator for such Big Pharmas as 
AstraZeneca
, Eli Lilly and 
Amgen
 in more than 100 clinical trials.
→ Chalking up $47 million in 
new funding
 to target metabolic diseases using incretin receptor agonists, Berkeley, CA-based 
Carmot Therapeutics
has welcomed
Manu Chakravarthy
 as CMO and EVP of R&D. Chakravarthy, whose involvement in Big Pharma R&D began at Merck, had previously been CMO of 
Axcella Health
. Before Axcella, he was Eli Lilly’s VP and global head of external R&D and innovation strategy in diabetes and cardiovascular research.
→ 
Iovance
makes
 their second C-suite hire in three months, with 
Igor Bilinsky
 jumping on board as COO (back in December, Jean Marc Bellemin 
was appointed
 CFO at the California cell therapy biotech). Bilinsky had most recently been CBO at
 Oncternal Therapeutics
, and he’s been a CEO before at 
Androclus Therapeutics
, which closed up shop in 2007. Bilinsky’s previous COO experience was with 
AmpliPhi Biosciences
 before his short stay at Oncternal.
→ T cell engager biotech 
Janux
 — joining forces on a $1 billion 
pact
 with Merck in one of Roger Perlmutter’s parting deals — 
has brought on
Andy Meyer
 as CBO. Meyer was 
Evercore
’s managing director in life sciences investment banking and spent nearly six years there after his time at 
Bank of America
. A couple weeks ago, Janux 
gathered up
 $56 million in a Series A raise that was spurred by the Merck deal.
→ 
Edward Smith
has signed on
 to 
Versant
–
backed
 bispecific gamma-delta T cell engager (or bsTCEs) biotech 
Lava Therapeutics
 to become its CFO. Before heading to the Dutch outfit, which just 
made
 Kapil Dhingra
 chairman of the board last month, Smith had spent eight years as CFO of 
Marinus Pharmaceuticals
, which 
read out
 positive data last fall with its lone drug that focuses on CDKL5 deficiency disorder.
→ 
Robert Willette
has tacked
 on the role of CSO at 
APIE Therapeutics
. Willette joins the company from 
Complexa Therapeutics
 and 
ImmuniMet Therapeutics
, where he served as interim CSO. Prior to that, Willette had a 30-year long stint at 
GSK
, where he most recently served as VP and head of the company’s heart failure and renal discovery performance unit.
→ 
Lisa Decker
 has left 
Atreca
to become
 CBO at Silicon Valley-based
 IGM Biosciences
, which — you guessed it — focuses on IgM antibodies and 
debuted
 on Nasdaq in 2019 with a $175 million IPO. Before her time as CBO at Atreca, she held various titles in 11 years at 
Nektar
, with her final role being VP, business development.
→ Shanghai-based 
Antengene
 made a few key hires last summer, 
including
 CMO
 Donald Lung
 and medical affairs VP 
Dirk Hoenemann
. Now the hematology and oncology player 
has welcomed
 Minyoung Kim
 as general manager of Antengene South Korea. She had previously been general manager of
 Ipsen Korea
 since 2015 and also brings marketing experience from 
Eli Lilly Korea
.
→ Spinning its wheels in Phase III of its Covid-19 
vaccine candidate
 while promising to respond to the FDA’s clinical hold, 
Inovio
has recruited
Michael Cordera
 as EVP and general counsel. Cordera, who had soared to EVP and general counsel at 
Eagle Pharmaceuticals
, joined the biotech as its deputy general counsel five years ago. In addition to the regulatory issues that beset Inovio, 
Joseph Kim
’s bunch also 
squabbled
 with its contract manufacturer, filing suit against 
VGXI
 to get unshackled from the relationship.
→ 
Boundless Bio
has named
Shailaja Kasibhatla
 as VP, discovery and translational development. Prior to her new role, Kasibhatla was senior director of translational development at 
Bristol Myers Squibb
. Before that, she had an eight-year stint at Novartis and served at Merck Research Labs.
→ Digital health-focused 
Welldoc
has named
Marina Dorotheo
 its chief marketing officer. Dorotheo jumps aboard after a 22-year stint at 
Otsuka
, most recently serving as head of commercial strategy and marketing within Otsuka’s Digital Medicine hub.
→ 
Rick Klausner
-chaired 
Lyell Immunopharma
 — focused on using T cells to cure solid tumors — 
has enlisted
Richard Sherry
 as SVP, TIL specialist and clinical lead. Most recently, Sherry served as research physician and attending surgeon in the surgery branch at the 
NCI Center for Cancer Research
 and the 
NCI Clinical Center
. In addition, he has held roles at the 
NIH
, the NIH Surgical Administrative Committee, the Saftey Monitoring Committee for the National Institute of Neurologic Disorders and Stroke and as a melanoma expert for the FDA’s Drug Advisory Committee.
→ Venture capital fund 
Section 23
has added
 two new hires to its team with the appointments of 
Andy Harrison
 as managing partner and 
Sue Hager
 as chief investor relations and communications officer. Harrison hops aboard with leadership experience from 
Alphabet
, 
Verily Life Sciences
 and 
X
 (formerly 
GoogleX
). Meanwhile, Hager most recently served at 
EQRx
 and 
Foundation Medicine
.
→ 
Komodo Health
has recruited
Laurent Bride
 as chief technology officer (CTO). Bride joins the group from software company 
Talend
, where he also served as CTO.
→ San Diego-based oncology biotech 
Aptose
has a pair
 of new execs with 
George Melko
 (VP, regulatory affairs) and 
Robert Killion
 (VP, CMC). A regulatory alum at AstraZeneca and 
Incyte
, Melko has recently served as VP of regulatory affairs at 
Tmunity
 and
 Tessa Therapeutics
. Killion lands this promotion to a newly-created gig after coming onto the scene at Aptose last year. He’s held CMC positions at Roche/Genentech — where he spent nearly two decades combined— and Gilead.
→ Ex-
Audentes
 chairman and CEO 
Matthew Patterson
has been named
 executive chairman of the board at 
Remix Therapeutics
, the Cambridge, MA RNA processing biotech that 
hauled in
 $81 million for its December 2020 launch. Patterson has since moved into a strategic advisory role with Audentes.
→
 Laura Shawver
 has a new board member at Seattle-based 
Silverback
 — a late 
entrant
 in 2020’s IPO bonanza — with the 
addition
 of
 Repare Therapeutics
 CMO 
Maria Koehler
. The ex-CMO of 
Bicycle Therapeutics
 was also an exec with Pfizer Oncology from 2009-17.
→ 
GSK
 vet and 
Travere Therapeutics
 CEO 
Eric Dube
has joined
 the board of directors at mitochondrial disease-focused 
Reneo Pharmaceuticals
. In two years at the biotech, Dube has led the post-
Martin Shkreli
 rebranding of 
Retrophin
, which 
became
 Travere back in November.
→ Former 
Merck
 CMO 
Michael Rosenblatt
is joining
 the board of directors at 
PYC Therapeutics
, adding another board seat to his résumé. Rosenblatt 
left his role
 at Merck in 2016 to join 
Flagship Pioneering
, where he now serves as a senior partner. Rosenblatt currently sits on the boards of 
Rubius
Therapeutics
, 
Cygnal
Therapeutics
 and 
Ohana
Biosciences
.
→ 
Sanofi
 delivered two sickle-cell programs from the 
Bioverativ
 deal to 
Global Blood Therapeutics
this week
, and 
Ted Love
’s crew 
has reserved
 a place for 
Alexis Thompson
 on the board of directors. A past president of the 
American Society of Hematology
, Thompson is head of the hematology section and director of the Comprehensive Thalassemia Program at the 
Lurie Children’s Hospital
 in Chicago.
→ 
Muna Bhanji
, who devoted more than 30 years to Merck, 
has another
 board appointment to her credit with 
Ardelyx
 as 
Gordon Ringold
 steps aside from the board. Bhanji, who capped her career at the pharma giant as SVP, global market access and policy, 
also joined
 the board at 
Cytokinetics
 a month ago.
→ Several months after 
adding
Replimune
’s 
Pamela Esposito
 and 
Blueprint Medicines
 CEO 
Jeff Albers
 to the board of directors,
 Kymera Therapeutics
has made room
 for 
Elena Ridloff
 on the board as well. Ridloff joined 
Acadia
 as VP, investor relations in 2018 and is currently CFO.
→ 
Trevena
is bringing
 Marvin Johnson
 into the fold on the board of directors, as founding CEO
 Maxine Gowen
 and 
Julie McHugh
 both retire from the board. Johnson retired from Merck in 2018 as chief learning officer in the pharma giant’s global learning and development department.
→ 
José-Carlos Gutiérrez Ramos
has locked in
 a seat on the board of directors at Genentech immuno-oncology partner Bicycle Therapeutics. The ex-CEO of 
Synlogic
 and 
Repertoire Immune Medicines
 is now CSO at 
Danaher
.
→ Waiting out a 
partial clinical hold
 from the FDA on its head and neck squamous cell carcinoma study, 
ALX Oncology
has elected
 Sophia Randolph
 to the board of directors. The Pfizer and Merck oncology alum has been ALX’s CMO for nearly five years.
→ Woburn, MA-based 
ReForm Biologics
has chosen
Barbara Finck
 to be a part of its board of directors. Currently, Finck serves as the acting CMO at 
Coherus BioSciences
. Finck has also held roles at 
Immunex
 and 
Eos Biotechnology
 among others.