Delving into the Latest Updates on Livzon Group Livzon Pharmaceutical Factory with Synapse

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Mouth and Tooth Diseases

Nervous System Diseases

Small molecule drug

Growth factors

Enzyme

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Disease Domain	Count

Nervous System Diseases	5
Infectious Diseases	4
Endocrinology and Metabolic Disease	2
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	10
Synthetic peptide	1
Growth factors	1
Biosimilar	1
Enzyme	1

Top 5 Target	Count

Proton pump	2
FDPS(Farnesyl diphosphate synthase)	1
50S subunit(50S ribosomal subunit)	1
TRHR(Thyrotropin releasing hormone receptor)	1
COX x β2-adrenergic receptor	1

Primary objective: To evaluate the pharmacokinetic characteristics of JP-1366 tablets after single and multiple oral administration of different doses in healthy Chinese subjects. Secondary objective: To evaluate the safety of JP-1366 tablets after single and multiple oral administration of different doses in healthy Chinese subjects, and the effect on the intragastric pH of healthy subjects.

Start Date07 May 2024

Sponsor / Collaborator

Lizhu Group Lizhu Medicine Research Institute

[+1]

CTR20241052 / Active, not recruitingNot Applicable

盐酸哌罗匹隆片在中国健康受试者中进行的单中心随机开放单次（空腹/餐后）口服给药两制剂两序列四周期完全重复交叉的人体生物等效性试验

[Translation] A single-center, randomized, open-label, single-dose (fasting/postprandial) oral bioequivalence study of two formulations, two sequences, four periods, and complete repeated crossover in healthy Chinese subjects

主要目的：以药代动力学参数作为主要终点评价指标，分别比较在空腹/餐后状态下口服受试制剂盐酸哌罗匹隆片（生产厂家：丽珠集团丽珠制药厂）与参比制剂盐酸哌罗匹隆片（持证商：住友ファーマ株式会社（日本住友制药有限公司），商品名：Lullan®）后在健康受试者体内的药代动力学行为，评价两种制剂的生物等效性。次要目的：观察受试制剂盐酸哌罗匹隆片和参比制剂盐酸哌罗匹隆片在健康受试者中的安全性。

[Translation]

Main purpose: Using pharmacokinetic parameters as the primary endpoint evaluation index, the pharmacokinetic behavior of the test preparation Perospirone Hydrochloride Tablets (manufacturer: Livzon Pharmaceutical Factory of Livzon Group) and the reference preparation Perospirone Hydrochloride Tablets (licensed by Sumitomo Pharmaceuticals Co., Ltd., trade name: Lullan®) in healthy subjects after oral administration in the fasting/postprandial state was compared to evaluate the bioequivalence of the two preparations. Secondary purpose: Observe the safety of the test preparation Perospirone Hydrochloride Tablets and the reference preparation Perospirone Hydrochloride Tablets in healthy subjects.

Start Date01 May 2024

Sponsor / Collaborator

Livzon Group Livzon Pharmaceutical Factory

CTR20233833 / RecruitingNot Applicable

精神分裂症患者接受棕榈酸帕利哌酮注射液多次给药的随机、开放、双交叉、双周期、稳态人体生物等效性试验

[Translation] A randomized, open-label, double-crossover, two-period, steady-state bioequivalence study of multiple doses of paliperidone palmitate injection in patients with schizophrenia

主要研究目的：评价精神分裂症患者多次肌肉注射受试制剂丽珠集团丽珠制药厂研制的棕榈酸帕利哌酮注射液（代号：LZ1069）和参比制剂原研厂家 Janssen Pharmaceutica N.V.研制的棕榈酸帕利哌酮注射液（商品名：善思达®）达稳态后两者的生物等效性。次要研究目的：评价受试制剂和参比制剂在中国精神分裂症患者中多次肌肉注射的安全性和耐受性。

[Translation]

Main study objectives: To evaluate the bioequivalence of the test preparation, paliperidone palmitate injection (code: LZ1069) developed by Livzon Pharmaceutical Factory of Livzon Group and the reference preparation, paliperidone palmitate injection (trade name: Susta®) developed by Janssen Pharmaceutica N.V., after multiple intramuscular injections in patients with schizophrenia reached steady state. Secondary study objectives: To evaluate the safety and tolerability of the test preparation and the reference preparation in Chinese patients with schizophrenia after multiple intramuscular injections.

Start Date11 Dec 2023

Sponsor / Collaborator

Livzon Group Livzon Pharmaceutical Factory

100 Clinical Results associated with Livzon Group Livzon Pharmaceutical Factory

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0 Patents (Medical) associated with Livzon Group Livzon Pharmaceutical Factory

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4

Literatures (Medical) associated with Livzon Group Livzon Pharmaceutical Factory

03 Oct 2019·Expert Opinion on Drug Delivery

Preparation of sterile long-acting injectable medroxyprogesterone acetate microcrystals based on anti-solvent precipitation and crystal habit control

Article

Author: He, Haibing ; Sun, Rong ; Zhang, Yu ; Gou, Jingxin ; Yin, Jiaojiao ; Yin, Tian ; Yin, Na ; Guo, Yuting ; Tang, Xing

Background: To overcome the rigorous aseptic process widely adopted by commercial long-acting injections, this work aimed to prepare a sterile MPA injection by manipulating the crystal habit through a bottom-up method. Methods: The habit of the precipitated crystals was modified by changing the process conditions. Wherein, the cubic crystal (MPA-C) was obtained by mixing acetonitrile and water at a ratio of 1:4 (v/v) under an ultrasonic condition. Spherical crystal (MPA-S) was prepared with acetonitrile-water mixture (1:20, v/v). The addition of external additives could stop a certain crystal surface growth to obtain rod-like crystal (MPA-R) and branched crystal (MPA-B). Results: All these crystals were proved to be of the same crystal form with different preferential growth orientation by PXRD, DSC, and SEM. The in vitro release of MPA-R microcrystal suspensions is faster than MPA-DP, while that of MPA-C is slightly slower. The relative bioavailability of MPA-C and MPA-R was 103.3% and 68.5%, respectively. The PK profile of MPA-C was most close to the commercial Depo-Provera® (MPA-DP) after intramuscular administration to male SD rats. Conclusions: A cubic crystal of MPA was successfully prepared by anti-solvent precipitation method with the aid of sonication, providing an alternative strategy for the preparation of long-acting injections.

Yaowu Fenxi Zazhi

Determination of ceftriaxone (CFT), 7-ACA and 7-ACT by ion-pair RP-HPLC

Author: Guo, Guoling ; Zhang, Weixin ; Jiang, Chungang

A reverse-phase HPLC method on ODS column with tetra-Bu ammonium bromide as ion-pair agent was developed for the quant. anal. of CFT, and its initial and intermediate compounds 7-ACA and 7-ACT.The mobile phase was acetonitrile-tetrabutyl ammonium bromide-pH 7 phosphate buffer-water (32:0.32:4.4:63.6).The eluant was detected at 270 nm, over the concentration range 9.36-234 μg/mL for 7-ACA, 10.4-260 μg/mL for 7-ACT, and 12.92-323 μg/mL for CFT, resp.The calibration curves were linear.The average recovery was 99.7-99.9% for 7-ACA, 99.5-99.8% for 7-ACT, and 100.0-100.4% for CFT resp.

Xiandai Shipin Yu Yaopin Zazhi

Determination of berberine hydrochloride in fat-soluble Qianliean suppositories by HPLC

Author: Yang, Wei-han ; Li, Yan

The paper established an HPLC method for the determination of berberine hydrochloride in fat-soluble Qianliean suppositories.The HPLC was performed on a Kromasil C₁₈ column (4.6 mm x 200 mm, 5 μm), using the mobile phase of acetonitrile-0.1% phosphoric acid solution (50 : 50) (0.1 g sodium dodecyl sulfate was dissolved in100 mL mobile phase), with the detection wavelength of 350 nm.Results showed that the calibration curve was linear in the range of 20-200 μg·ml^-1.The average recovery was 98.9% and RSD was 0.5%.In conclusion, this method was sensitive, accurate, simple, and could be used for determination of berberine hydrochloride in fat-soluble Qianliean suppositories.

100 Deals associated with Livzon Group Livzon Pharmaceutical Factory

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100 Translational Medicine associated with Livzon Group Livzon Pharmaceutical Factory

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Pipeline

Pipeline Snapshot as of 05 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

12

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Incadronate Disodium ( FDPS )	Osteoporosis More	Approved
Isosorbide Mononitrate	Heart Failure More	Approved
Urokinase(Livzon Group Livzon Pharmaceutical Factory) ( PLG )	Thromboembolism More	Approved
Clarithromycin ( 50S subunit )	Tonsillitis More	Approved
Mouse nerve growth factor(Livzon Pharmaceutical Group, Inc.) ( p75NTR )	Optic Nerve Injuries More	Approved