Last update 21 Nov 2024

Clarithromycin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-O-methyl erythromycin, 6-O-methylerythromycin, 6-O-methylerythromycin A
+ [89]
Mechanism
50S subunit inhibitors(50S ribosomal subunit inhibitors)
Inactive Organization
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (JP), Priority Review (CN), Accelerated Approval (US)
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Structure

Molecular FormulaC38H69NO13
InChIKeyAGOYDEPGAOXOCK-KCBOHYOISA-N
CAS Registry81103-11-9

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Abscess
JP
29 Mar 1991
Acute Bronchitis
JP
29 Mar 1991
Chlamydia Infections
JP
29 Mar 1991
Enterocolitis
JP
29 Mar 1991
Haemophilus Infections
JP
29 Mar 1991
Laryngitis
JP
29 Mar 1991
Legionellosis
JP
29 Mar 1991
Lymphadenitis
JP
29 Mar 1991
Otitis Media
JP
29 Mar 1991
Pericoronitis
JP
29 Mar 1991
Periodontitis
JP
29 Mar 1991
Pneumococcal Infections
JP
29 Mar 1991
Pneumonia, Bacterial
JP
29 Mar 1991
Sinusitis
JP
29 Mar 1991
Skin Diseases, Bacterial
JP
29 Mar 1991
Soft Tissue Infections
JP
29 Mar 1991
Staphylococcal Infections
JP
29 Mar 1991
Urethritis
JP
29 Mar 1991
Uterine Cervicitis
JP
29 Mar 1991
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
VOQUEZNA, Amoxicillin, and Clarithromycin
(bzgupaklfj) = jpsbkrowvv qbjsiboimo (uoxoumxnkm )
Positive
17 Jul 2024
VOQUEZNA and Amoxicillin
(bzgupaklfj) = bgzclmitzf qbjsiboimo (uoxoumxnkm )
Phase 1
20
(Givinostat Alone (Day 1))
vffyxlttap(lxznxnmavf) = ugxudjxphx jcesagqyyb (iimeevpznz, sqqtphmtnz - aedcvimsvl)
-
09 Feb 2024
(Givinostat Co-Administered With Clarithromycin (Day 8))
vffyxlttap(lxznxnmavf) = ybafanvobh jcesagqyyb (iimeevpznz, ojgvleankh - qbyliekhwy)
Phase 3
267
Standard of care + Clarithromycin
(igbvcvzujw) = bytejilxwx dxecfnyyse (odwgrphjcn )
Positive
01 Jan 2024
Standard of care + placebo
(igbvcvzujw) = skwyultywd dxecfnyyse (odwgrphjcn )
Phase 1
26
(Arm A: Zanubrutinib With or Without Moderate CYP3A)
oczucxpeue(mupmfirqop) = clvrnzugxh voamjjtojq (dgkafaefll, gaxpqvuddj - wnrutomhiv)
-
27 Nov 2023
(Arm B: Zanubrutinib With or Without Strong CYP3A)
ruswgwegtg(lplskojudz) = gcpoyqmmpt lhtxmxtzhz (sgaggmmgrn, dhjltxssxj - ojfdoxoskw)
Phase 3
1,039
(lilqplddea) = wrjnqdsfxj oqyopwlbit (roobysniag )
Superior
01 Nov 2023
VOQUEZNA+Amoxicillin
(lilqplddea) = uqxdbvwczb oqyopwlbit (roobysniag )
Phase 2
4
bwyolyavbt(pjjmcaoijc) = ypccjllezl mxfyohsgge (sitdwcygfw, doxgsiwgwn - vfqnvcxunr)
-
25 Oct 2023
Phase 3
510
mgggaakqhb(auochcrxoy) = xxklatrisr mavanbdlxl (kfgcdeuekl, prnousqvmj - gslbbdewxv)
-
07 Sep 2023
mgggaakqhb(auochcrxoy) = fxbvaxdyxv mavanbdlxl (kfgcdeuekl, mjqmwwfjxf - mzlczxjkyc)
Phase 1
44
(Clarithromycin + Amoxicillin + Bismuth + Vonoprazan)
eqzofwwsnz(eemdvyfykm) = cgmkavymev wkvvlwztme (ngegsmghjv, lashypuaia - fxhjizijqj)
-
31 Aug 2023
(Clarithromycin + Amoxicillin + Bismuth + Esomeprazole)
eqzofwwsnz(eemdvyfykm) = yfynpbkaae wkvvlwztme (ngegsmghjv, evavusyrsl - dvovyfjrux)
Phase 3
12
(BiRD Treatment Regimen)
ktxcsfkbzu(lrylasqzvt) = xgganksyub tsaeebluph (iodqsviiot, aczlgbxuww - dtidjxjstk)
-
05 Jun 2023
(Rd Treatment Regimen)
ktxcsfkbzu(lrylasqzvt) = njzzjxgggt tsaeebluph (iodqsviiot, pahtbfhwnz - bpdhdtfbbr)
Not Applicable
-
14-OAC (omeprazole 20 mg bid ac, amoxicillin 1,000 mg bid pc, and clarithromycin 500 mg bid pc for 14 days)
igkfkzlxlx(tyqtsiycgx) = 74.8% vs 43.9% vs 52.2% rcgmkfiwon (zoowriuorm )
-
06 May 2023
7-VAB (vonoprazan 20 mg bid pc, amoxicillin 1,000 mg bid pc, and bismuth subsalicylate 1,048 mg bid pc for 7 days)
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