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Neoplasms

Immune System Diseases

Other Diseases

Small molecule drug

AAV based gene therapy

Cell therapy

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A glimpse into the focused therapeutic areas

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Most used technologies in drug development

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Disease Domain	Count

Neoplasms	7
Immune System Diseases	3
Endocrinology and Metabolic Disease	2
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	4
AAV based gene therapy	1
Cell therapy	1
Fusion protein	1
Prophylactic vaccine	1

Top 5 Target	Count

PIEZO1(piezo type mechanosensitive ion channel component 1)	1
DNAJC27 x GTPase x MEK1 x RET	1
WNT1(Wnt family member 1)	1
CXCR4(C-X-C motif chemokine receptor 4)	1
RHBDD1(rhomboid domain containing 1)	1

在Ⅳ期非小细胞肺癌（NSCLC）患者中比较100mg CAI胶丸与长春瑞滨+顺铂联用和安慰剂与长春瑞滨+顺铂联用作为一线方案治疗的有效性和安全性。主要疗效指标：无进展生存期（PFS）。次要疗效指标：客观有效率（CR+PR）、疾病控制率 (CR+PR+SD)、总生存期（OS）、生活质量。

[Translation]

To compare the efficacy and safety of 100 mg CAI capsules in combination with vinorelbine + cisplatin and placebo in combination with vinorelbine + cisplatin as first-line treatment in patients with stage IV non-small cell lung cancer (NSCLC). Primary efficacy indicator: progression-free survival (PFS). Secondary efficacy indicators: objective response rate (CR+PR), disease control rate (CR+PR+SD), overall survival (OS), and quality of life.

Start Date11 Sep 2011

Sponsor / Collaborator

Guangdong Yinzhu Group Co., Ltd.

[+1]

CTR20132698

/ CompletedPhase 2IIT

骨髓间充质干细胞对预防急性GVHD的研究

[Translation] Study on the prevention of acute GVHD by bone marrow mesenchymal stem cells

选择需要接受造血干细胞移植治疗具有高GVHD风险的血液病的患者作为受试者，对比研究单纯的造血干细胞移植与骨髓原始间充质干细胞和造血干细胞共移植的临床及实验室指标，主要观察联合骨髓原始间充质干细胞移植能否降低GVHD发生率、严重程度，同时观察对造血重建的影响，是否能提高移植成功率。对安全性进一步进行评价。

[Translation]

Patients with blood diseases with high risk of GVHD who need hematopoietic stem cell transplantation were selected as subjects. The clinical and laboratory indicators of simple hematopoietic stem cell transplantation and co-transplantation of bone marrow primitive mesenchymal stem cells and hematopoietic stem cells were compared. The main purpose was to observe whether combined bone marrow primitive mesenchymal stem cell transplantation can reduce the incidence and severity of GVHD, and at the same time observe the impact on hematopoietic reconstruction and whether it can improve the success rate of transplantation. Safety was further evaluated.

Start Date01 Jun 2007

Sponsor / Collaborator

Institute of Basic Medical Sciences

CTR20132003

/ CompletedPhase 2IIT

骨髓间充质干细胞对预防急性GVHD的研究

[Translation] Study on the prevention of acute GVHD by bone marrow mesenchymal stem cells

选择需要接受造血干细胞移植治疗具有高GVHD风险的血液病的患者作为受试者，对比研究单纯的造血干细胞移植与骨髓原始间充质干细胞和造血干细胞共移植的临床及实验室指标，主要观察联合骨髓原始间充质干细胞移植能否降低GVHD发生率、严重程度，同时观察对造血重建的影响，是否能提高移植成功率。对安全性进一步进行评价。

[Translation]

Patients with blood diseases with high risk of GVHD who need hematopoietic stem cell transplantation were selected as subjects. The clinical and laboratory indicators of simple hematopoietic stem cell transplantation and co-transplantation of bone marrow primitive mesenchymal stem cells and hematopoietic stem cells were compared. The main purpose was to observe whether combined bone marrow primitive mesenchymal stem cell transplantation can reduce the incidence and severity of GVHD, and at the same time observe the impact on hematopoietic reconstruction and whether it can improve the success rate of transplantation. Safety was further evaluated.

Start Date01 Aug 2006

Sponsor / Collaborator

Institute of Basic Medical Sciences

100 Clinical Results associated with Institute of Basic Medical Sciences

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0 Patents (Medical) associated with Institute of Basic Medical Sciences

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2,073

Literatures (Medical) associated with Institute of Basic Medical Sciences

01 May 2025·The Laryngoscope

Approaches to Increase Early Detection and Positive Biopsy Rate of Nasal Natural Killer/T‐Cell Lymphoma

Article

Author: He, Xiaojin ; Huang, Qian ; Zhou, Bing ; Liu, Yunfu ; Sun, Yan ; Cui, Shunjiu ; Han, Huijun ; Dong, Yi

ObjectivesTo develop methods for early detection of natural killer/T‐cell lymphoma, nasal type (nasal NKTL) and to evaluate the use of apparent diffusion coefficient (ADC) measurements from diffusion‐weighted imaging (DWI) for selecting biopsy sites to enhance the positive biopsy rate.MethodsThe clinical data of 32 cases of nasal NKTL were retrospectively collected and analyzed. Cases were graded from 1 to 5 based on endoscopic and imaging findings. Biopsy methods included the superficial forceps method and deep incisional method. Data recorded included biopsy method, time to confirmed diagnosis, number of biopsies required, and ADC values of biopsy sites.ResultsBoth endoscopic and MRI lesion severity did not affect biopsy outcomes (p = 0.8248, 0.7571). The deep incisional biopsy method had a significantly higher probability of yielding positive pathological results compared to the superficial clamping method [OR (95% CI) = 23.2143 (6.0448, 89.1513) (χ2 = 26.1089, p < 0.0001)]. The ADC value at the site with a positive biopsy result is significantly lower than at the site with a negative result (p = 0.0003). The diagnostic threshold for ADC value to predict a positive biopsy result was 0.603 × 10−3 mm2/s, with a Youden index of 0.43.ConclusionsNasal NKTL has distinct characteristics distinguishing it from sinusitis and other tumors. Deep incision biopsy under general anesthesia is superior to the superficial method. The location of the positive sampling site can be guided by measuring the ADC value, and the optimal diagnostic threshold of this proposed method is 0.603 × 10−3 mm2/s.Level of Evidence4 Laryngoscope, 135:1598–1606, 2025

21 Apr 2025·ACS Applied Bio Materials

Biocompatible OFETs for Selective and Real-Time Bacterial Detection Using BSA and Lysozyme Layers

Article

Author: Cheng, Horng-Long ; Fang, Po-Hsiang ; Wang, Shuying ; Huang, Wen-Chun ; Chou, Wei-Yang ; Chen, Guan-Xu ; Teng, Ching-Hao

In the realms of modern medicine and environmental monitoring, there is an escalating demand for bacterial detection technologies that are rapid, precise, and highly sensitive. Conventional methods, however, are often hindered by their time-intensive nature, procedural complexity, and reliance on specialized laboratory equipment. This study introduces an innovative approach utilizing bovine serum albumin (BSA) as the dielectric layer and lysozyme (LYZ) as the bacterial sensing layer in organic field-effect transistors (OFETs). The combination of BSA and LYZ enhances both biocompatibility and detection sensitivity, enabling precise differentiation between Gram-positive and Gram-negative bacteria. BSA not only stabilizes the electrical performance of the OFET but also offers biodegradability and water solubility, contributing to environmental sustainability. These biocompatible OFETs can accurately detect bacterial concentrations ranging from 10⁴ to 10⁸ CFU/mL, with real-time response capabilities via multispike measurements. This research represents a significant step forward in the development of advanced, portable biosensors for use in complex biological environments, advancing bacterial detection technology.

21 Apr 2025·ACS Applied Bio Materials

Selective Photothermal Eradication of Glioblastoma Cells Coexisting with Astrocytes by Anti-EGFR-Coated Raman Tags

Article

Author: Sze, Chun-I ; Liu, Chan-Chuan ; Chang, Yung-Ching ; Chan, Wan-Ping ; Lin, Yu-Long ; Chen, Shiuan-Yeh

Glioblastoma (GBM) is an aggressive and fatal tumor. The infiltrative spread of GBM cells hinders gross total resection. The residual GBM cells are significantly associated with survival and recurrence. Therefore, a theranostic method that can enhance the contrast between residual GBM and normal astrocyte (AS) cells and selectively eradicate GBM cells is highly desired. In this report, GBM and normal astrocyte cells are both cultured in the same microplate well to imitate a coexistence environment and treated with Raman tags functionalized by anti-EGFR. Compared to AS cells, GBM cells show 25% higher Raman emission, and their cell death rate increases by a factor of 2. These results demonstrate the potential for selective eradication of the residual GBM cells guided by robust Raman signals after the primary GBM surgery.

100 Deals associated with Institute of Basic Medical Sciences

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100 Translational Medicine associated with Institute of Basic Medical Sciences

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Pipeline

Pipeline Snapshot as of 22 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

9

1

Preclinical

Other

3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Human Papillomavirus Vaccines(Institute of Basic Medical Sciences)	Virus Diseases More	Preclinical
CN118439991 ( DNAJC27 x GTPase x MEK1 x RET )	Neoplasms More	Discovery
CN117229205 ( RHBDD1 )	Neoplasms More	Discovery
CN117653733 ( PIEZO1 )	Neoplasms More	Discovery
CN118126196 ( TNFSF )	Immune System Diseases More	Discovery