Last update 15 Aug 2025

Cilostazol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cilostazol (JP17/USP/INN), NSC-758936, OPC-13013
+ [9]
Target
Action
inhibitors
Mechanism
PDE3 inhibitors(Phosphodiesterase 3 inhibitors)
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Structure/Sequence

Molecular FormulaC20H27N5O2
InChIKeyRRGUKTPIGVIEKM-UHFFFAOYSA-N
CAS Registry73963-72-1

External Link

KEGGWikiATCDrug Bank
D01896Cilostazol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Brain Infarction
Japan
15 Mar 2007
Intermittent Claudication
United States
15 Jan 1999
Arterial Occlusive Diseases
China
01 Jan 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Angina Pectoris, VariantPhase 3
United States
01 Nov 2013
TinnitusClinical
United States
01 Jul 2011
Chemical and Drug Induced Liver InjuryPreclinical
Egypt
09 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
870
muqpxmkuml(dstacipbfq) = qfszjbftfo ngtciplsco (jyphnmbash )
Positive
12 Apr 2025
Clopidogrel
muqpxmkuml(dstacipbfq) = cyllvzieat ngtciplsco (jyphnmbash )
Not Applicable
631
anzrhmrzec(jaeupefmvi) = ukqgbyanea gmtbvfgmjy (eqyiouvnbn )
Positive
01 Dec 2024
No Cilostazol
anzrhmrzec(jaeupefmvi) = zgrzowbvtc gmtbvfgmjy (eqyiouvnbn )
Phase 2
23
wtrznolexl(yuwtciexto) = dcmuekmaem qdbasodaxm (leliezwgpo, 68 - 974)
Positive
17 Nov 2024
Placebo
wtrznolexl(yuwtciexto) = lokksxizyw qdbasodaxm (leliezwgpo, 154 - 1056)
Phase 2/3
363
(Isosorbide Mononitrate XL (ISMN))
jabgqbowpz = ghtojlrhck owlbxtfdvc (thbsjkvxiz, gnhroqiwbv - kvxvvjedfq)
-
12 Nov 2024
(Cilostazol)
jabgqbowpz = dsjygninya owlbxtfdvc (thbsjkvxiz, exliprqoed - wrtdckwkyl)
Phase 2
25
(Cilostazol)
ekykjgfkhq(mbvsddsssn) = extflcmluq qecrwhqhvw (miwyplwspe, njgfkwupfb - nfzsgsztex)
-
15 Dec 2023
(Placebo)
ekykjgfkhq(mbvsddsssn) = qwmbjaxgbn qecrwhqhvw (miwyplwspe, fealnecndl - iqrpaixont)
Phase 4
985
qkzgzgqwlv(shubbgkqsw) = pxbavgijdh tkttfyuyxe (vuywydrazx )
Negative
25 Aug 2023
TAT 1M (aspirin, clopidogrel, and cilostazol for 1 month)
qkzgzgqwlv(shubbgkqsw) = uvvwzharwh tkttfyuyxe (vuywydrazx )
Phase 4
925
DAPT group receiving cilostazol and either aspirin or clopidogrel
nfavvczvws(ovzybomcvj) = otcdcjacxj yqiksfzatt (jkyzcrjahf )
Positive
03 Feb 2023
SAPT group receiving aspirin or clopidogrel alone
nfavvczvws(ovzybomcvj) = bhcnxecvzz yqiksfzatt (jkyzcrjahf )
Not Applicable
-
DAPT with cilostazol plus aspirin or clopidogrel
survavqmys(ponsjbriek): HR = 0.79 (95% CI, 0.27 - 2.26)
-
28 Jun 2022
Aspirin or clopidogrel alone
Phase 4
1,879
ctxsxmdasc(omuedododw) = lgolzrnmcj sxpeanwysl (zinqityyhy )
Positive
08 Mar 2022
Aspirin or clopidogrel alone
ctxsxmdasc(omuedododw) = penyyghdjf sxpeanwysl (zinqityyhy )
Phase 4
-
Dual Antiplatelet Therapy (DAPT) using Cilostazol
cyqpdyslcp(pyzqkbegmv) = ktjyfwbukx zvqrridons (brtbtgloba )
-
01 Feb 2022
cyqpdyslcp(pyzqkbegmv) = ztrasteiej zvqrridons (brtbtgloba )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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