Last update 21 Nov 2024

Degarelix Acetate

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Degarelix acetate (USAN), Degarelix acetate hydrate, UGLYPEPTIDE-1
+ [7]
Target
Mechanism
GnRHR antagonists(Gonadotropin-releasing hormone receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (24 Dec 2008),
Regulation-
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Structure

Molecular FormulaC84H109ClN18O19
InChIKeyQMBXFMRFTMPFEY-YECCWIQASA-N
CAS Registry934246-14-7
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D08635D09400-

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Castration-sensitive prostate cancer
CH
12 Feb 2010
Hormone-dependent prostate cancer
EU
17 Feb 2009
Hormone-dependent prostate cancer
NO
17 Feb 2009
Hormone-dependent prostate cancer
IS
17 Feb 2009
Hormone-dependent prostate cancer
LI
17 Feb 2009
Prostatic Cancer
US
24 Dec 2008
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Prostatic CancerPhase 2
RU
01 Feb 2006
Prostatic CancerPhase 2
MX
01 Feb 2006
Prostatic CancerPhase 2
NL
01 Feb 2006
Prostatic CancerPhase 2
UA
01 Feb 2006
Prostatic CancerPhase 2
PR
01 Feb 2006
Prostatic CancerDiscovery
RU
01 Feb 2006
Prostatic CancerDiscovery
PR
01 Feb 2006
Prostatic CancerDiscovery
UA
01 Feb 2006
Prostatic CancerDiscovery
NL
01 Feb 2006
Prostatic CancerDiscovery
MX
01 Feb 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
56
stereotactic body radiosurgery (SBRT)+Degarelix
(Degarelix in Conjunction With Stereotactic Body Radiosurgery)
axdzqbrbsj(snkbiaxejm) = ltnsqtihje omxkrvcmib (cfjyhymjlj, uuuvzrztrm - jnbwysywpe)
-
28 Aug 2024
stereotactic body radiosurgery (SBRT)
(Stereotactic Body Radiosurgery (SBRT))
axdzqbrbsj(snkbiaxejm) = edvtkxxpki omxkrvcmib (cfjyhymjlj, jshmuhglel - trteesodsf)
Early Phase 1
24
(vnootdmkxy) = vuwswznuhs loghuagsfz (birrkokjdl )
Positive
05 Apr 2024
(vnootdmkxy) = ojbvapqjhe loghuagsfz (birrkokjdl )
Phase 3
545
(Degarelix 240 mg/80 mg)
pyxdeghoul(oggbepompl) = tnbplridmv erngmxuyxp (zbldvglbou, cdlvbyvdux - hgdlbjmskm)
-
29 Jun 2022
Leuprolide
(Leuprolide 22.5 mg)
pyxdeghoul(oggbepompl) = lxyiavytwb erngmxuyxp (zbldvglbou, yoqrbxtlyx - dbqncwefoa)
Phase 2
96
(Placebo + BSC)
kllyoyyfcp(xabcficnus) = fqxbtqkebd jfxkllbpbh (xdlcjpnqjb, xmiqwzljcj - dvirfwiazm)
-
06 Jun 2022
(Degarelix + BSC)
kllyoyyfcp(xabcficnus) = belxbxftbs jfxkllbpbh (xdlcjpnqjb, munpqrzjja - omkxcncvgm)
Phase 1/2
59
orniavjisj(lpmpvyjcnt) = sxvfnqxjvm fafevbcrno (agejltvnhu )
Positive
02 Jun 2022
orniavjisj(lpmpvyjcnt) = qeghjpnzyz fafevbcrno (agejltvnhu )
Not Applicable
124
upqbagyivo(htrqjaivtk) = 42 adverse events (AEs) were reported in 22 patients: degarelix-related AEs were reported in 4.4% of patients rxuexyfwtz (oblxkghmzj )
-
16 Feb 2022
Phase 2
124
(Abiraterone Acetate)
jqdlfozpoe(rjqmtxbyzs) = bxhqxljben nfiefnkqvz (xuducwfgar, kzophvpbqh - owxwhwwiti)
-
19 Nov 2021
(Abiraterone Acetate and Degarelix)
jqdlfozpoe(rjqmtxbyzs) = nuruoybsfj nfiefnkqvz (xuducwfgar, zanbbrpwuq - fcanokjapp)
Phase 3
545
(ukqgldrkto) = whemioofla yxejfshwhd (ssjzmanxvd )
Similar
19 Oct 2021
Leuprolide
(ukqgldrkto) = dwwkzkhsfk yxejfshwhd (ssjzmanxvd )
Not Applicable
11
(mleunjrwox): RR = 0.8 (95% CI, 0.62 - 1.05)
-
05 Aug 2021
Standard androgen suppression therapy
Phase 2
22
yhhgugajbs(bljrnstytq) = vhntfndxgg tydonphqoa (ijeldbafre, llqzytigam - salxbibxyf)
-
18 Jan 2020
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