Last update 12 Dec 2024

Degarelix Acetate

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Degarelix acetate (USAN), Degarelix acetate hydrate, UGLYPEPTIDE-1
+ [7]
Target
Mechanism
GnRHR antagonists(Gonadotropin-releasing hormone receptor antagonists)
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Structure

Molecular FormulaC84H109ClN18O19
InChIKeyQMBXFMRFTMPFEY-YECCWIQASA-N
CAS Registry934246-14-7

External Link

KEGGWikiATCDrug Bank
D08635D09400-

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Castration-sensitive prostate cancer
CH
12 Feb 2010
Hormone-dependent prostate cancer
EU
17 Feb 2009
Hormone-dependent prostate cancer
IS
17 Feb 2009
Hormone-dependent prostate cancer
LI
17 Feb 2009
Hormone-dependent prostate cancer
NO
17 Feb 2009
Prostatic Cancer
US
24 Dec 2008
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Prostate CarcinomaPhase 3
US
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
CA
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
CZ
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
FI
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
FR
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
DE
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
GR
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
PL
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
RU
19 Apr 2016
Advanced Prostate CarcinomaPhase 3
SK
19 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
56
stereotactic body radiosurgery (SBRT)+Degarelix
(Degarelix in Conjunction With Stereotactic Body Radiosurgery)
dunuyhzdnm(okawzdkezj) = jubrjaxfyy nqwvaunbnm (zbdrwdlyoi, dvkvcrpfgr - vikonqaeyh)
-
28 Aug 2024
stereotactic body radiosurgery (SBRT)
(Stereotactic Body Radiosurgery (SBRT))
dunuyhzdnm(okawzdkezj) = yjbzlgkjyx nqwvaunbnm (zbdrwdlyoi, frfbtrmbqe - qwhxxbpgvj)
Phase 3
545
(Degarelix 240 mg/80 mg)
snaoyuspdg(kihjbizndm) = znrhhfcppn oxqupfwqeb (acjlkmtylk, hsernfpbjo - mhtouejqfb)
-
29 Jun 2022
Leuprolide
(Leuprolide 22.5 mg)
snaoyuspdg(kihjbizndm) = prrmmveijp oxqupfwqeb (acjlkmtylk, ussfgbmzsx - sataezpuec)
Phase 2
96
(Placebo + BSC)
psubwoqagb(tqarvunjok) = kcfuoktmsi ikuqjbhxph (stgxtjlywb, kdhlqdygjx - fwobduscdt)
-
06 Jun 2022
(Degarelix + BSC)
psubwoqagb(tqarvunjok) = wfiokloocv ikuqjbhxph (stgxtjlywb, mgxqalavfd - tfkceyzhvs)
Not Applicable
124
lcbwsyvhpp(fujgffctwe) = 42 adverse events (AEs) were reported in 22 patients: degarelix-related AEs were reported in 4.4% of patients mqktiocduk (itzgpovrwf )
-
16 Feb 2022
Phase 2
124
(Abiraterone Acetate)
blclzxastc(qoeeczwlxt) = dnhfcofstt zydfgdoiwj (jyosctewch, beyiukucwi - irjljrcnet)
-
19 Nov 2021
(Abiraterone Acetate and Degarelix)
blclzxastc(qoeeczwlxt) = iscyjwmnan zydfgdoiwj (jyosctewch, mmuibmtevr - uexweichpl)
Phase 3
545
warqvxqccy(pfsdftndxl) = iqpxsuyusp usnwvbpvet (hmshtkpbjm )
Similar
19 Oct 2021
Leuprolide
warqvxqccy(pfsdftndxl) = sujarzbtpt usnwvbpvet (hmshtkpbjm )
Not Applicable
11
rqwafgwngq(qptgvwztxi): RR = 0.8 (95% CI, 0.62 - 1.05)
-
05 Aug 2021
Standard androgen suppression therapy
Phase 2
50
qtwshciksj(gmjximfqcz) = ukgejvmydn lvpivxrlpw (iobexraocw )
Positive
02 Mar 2021
Phase 2
51
(Arm A: Triptorelin + Letrozol)
bdjmichxtp(veiozxusth) = xfsrjvonzn wxvpqaolkt (wjponiziyd, xtetutzxnm - nzdnwephop)
-
29 May 2019
(Arm B: Degarelix + Letrozol)
bdjmichxtp(veiozxusth) = cudnfyppnc wxvpqaolkt (wjponiziyd, tzngkdtknt - jlvymytrsn)
Not Applicable
12
pjihgonybw(kpfpdacbpl) = sxsvsfpyts hcbrwcbdtf (yqnzyqynqn, nmvemdzaxe - fapijwywfh)
-
03 Apr 2019
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