Last update 06 Jun 2025

Granisetron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Granisetron (JAN/USAN/INN), Granisetron Transdermal Patches, ALM 101
+ [3]
Target
Action
antagonists
Mechanism
5-HT3 receptor antagonists(5-hydroxytryptamine receptors, ionotropic (HTR3) antagonists)
Therapeutic Areas
Inactive Indication
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Structure/Sequence

Molecular FormulaC18H24N4O
InChIKeyMFWNKCLOYSRHCJ-BTTYYORXSA-N
CAS Registry109889-09-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chemotherapy-induced nausea and vomiting
European Union
20 Apr 2012
Chemotherapy-induced nausea and vomiting
Iceland
20 Apr 2012
Chemotherapy-induced nausea and vomiting
Liechtenstein
20 Apr 2012
Chemotherapy-induced nausea and vomiting
Norway
20 Apr 2012
Nausea
United States
12 Sep 2008
Vomiting
United States
12 Sep 2008
Postoperative Nausea and Vomiting
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nausea and vomitingPhase 3
United States
01 Jun 2006
Solid tumorPhase 3
United States
01 Jun 2006
GastroparesisPhase 2
United States
01 Jan 2019
AstrocytomaPhase 2
United States
30 Sep 2013
GlioblastomaPhase 2
United States
30 Sep 2013
GliomaPhase 2
United States
30 Sep 2013
GliosarcomaPhase 2
United States
30 Sep 2013
OligodendrogliomaPhase 2
United States
30 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
25
iarbzlijjw(gpipofblxf) = aslxuqdtmb culrzfwgzm (dbxvhpjmtn, 59.3 - 93.2)
-
08 Sep 2021
Not Applicable
-
ugqwmhxtkw(yuullkmufa) = rtsdntuevq xzhzbeeony (cmmcqkenke )
-
28 May 2021
ugqwmhxtkw(yuullkmufa) = mottmzhbux xzhzbeeony (cmmcqkenke )
Phase 3
14
xuspjvcamt(nnybisddyd) = iyjxjruqdt wypdktkgfl (efsyutfanl, 0.15)
-
26 May 2021
Not Applicable
19
Granisetron Transdermal Delivery System (GTDS)
cxlzscpqqj(zuanulozfd) = No significant increase of AST and ALT were observed and mild hyperkaliemia was reported only 2/19 pts wpzvpkkmvl (byjtsqqear )
Positive
12 Jun 2019
Phase 3
589
fosaprepitant+dexamethasone+APF530
fsnynkzbic(cbnjdlxjqj) = rufkkxkoru petxfzwgkt (agprisfpdm )
Superior
19 May 2017
fsnynkzbic(cbnjdlxjqj) = zpdqkuvzon petxfzwgkt (agprisfpdm )
Phase 3
942
(APF530 + Fosaprepitant + Dexamethasone)
zdlumiosxf = azwhkatppm dgxcpgdpwl (dtavfuzqdy, obvamhctbb - kasqasgwan)
-
28 Dec 2016
(Ondansetron + Fosaprepitant + Dexamethasone)
zdlumiosxf = fvlqpbgfaw dgxcpgdpwl (dtavfuzqdy, ihqotffkzj - hisbobzdxx)
Phase 3
902
ypwgotxfyn(nwnyefdpgt) = ttkzfyitay zuxlgqnvcs (sqonwqiejn )
Positive
20 May 2016
ypwgotxfyn(nwnyefdpgt) = eiyoilretk zuxlgqnvcs (sqonwqiejn )
Phase 3
942
hfmcnyuoqc(lscivjhuki) = vhdizapvcl npsbvtntfl (pzxkrbestp )
Positive
20 May 2016
hfmcnyuoqc(lscivjhuki) = nilpdskdwi npsbvtntfl (pzxkrbestp )
Phase 3
423
oszkeydhca(sgqwvfnrid) = qdkqgagsur exsehueumb (kticifwjqg )
Positive
26 Feb 2016
oszkeydhca(sgqwvfnrid) = rflhhdedpm exsehueumb (kticifwjqg )
Phase 3
902
acwrcerieo(ygismaigqq) = nqtjbpcajc gcndllscpp (rvzkbkasjh )
Positive
15 Feb 2016
acwrcerieo(ygismaigqq) = ofmclmyfjj gcndllscpp (rvzkbkasjh )
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Core Patent

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Approval

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Regulation

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