Last update 15 Jul 2024

Letrozole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Letrozol, Letrozole (JAN/USP/INN), CGP 20267
+ [11]
Mechanism
ERs antagonists(Estrogen receptors antagonists), aromatase inhibitors(Aromatase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
SE (10 Dec 1996),
RegulationAccelerated Approval (US), Priority Review (CN)
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Structure

Molecular FormulaC17H11N5
InChIKeyHPJKCIUCZWXJDR-UHFFFAOYSA-N
CAS Registry112809-51-5

External Link

KEGGWikiATCDrug Bank
D00964Letrozole

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Infertility
JP
25 Feb 2022
Metastatic breast cancer
US
25 Jul 1997
Breast Cancer
SE
10 Dec 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Leukodystrophy, Hypomyelinating, 6Phase 3
IT
02 Feb 2018
Advanced cancerPhase 3
US
30 Nov 2016
Advanced cancerPhase 3
AR
30 Nov 2016
Advanced cancerPhase 3
AT
30 Nov 2016
Advanced cancerPhase 3
BE
30 Nov 2016
Advanced cancerPhase 3
BG
30 Nov 2016
Advanced cancerPhase 3
CA
30 Nov 2016
Advanced cancerPhase 3
CL
30 Nov 2016
Advanced cancerPhase 3
CZ
30 Nov 2016
Advanced cancerPhase 3
DK
30 Nov 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HER2-negative breast cancer
Neoadjuvant
Ki67 | Recurrence Score (RS)
-
Letrozole/abemaciclib
gtroxlsvel(rsvqnvhpld) = pxwygainux xoinshxeqy (sjcqfmaamu )
Negative
24 May 2024
Chemotherapy
gtroxlsvel(rsvqnvhpld) = uosszpzymb xoinshxeqy (sjcqfmaamu )
Phase 2
Endometrial Carcinoma
CTNNB1 | KRAS | CDKN2Amutation ...
28
Letrozole/abemaciclib
yxdaevzfhd(ofzhmlrsej) = ekddzloypl ciiveocryh (dgbblpvcxx )
Positive
24 May 2024
Not Applicable
102
initially received letrozole then switched to exemestane
dqawkyuodl(jgaagwappw) = yecowpjxqz umxeegpztv (sanhgufvpf )
Superior
15 May 2024
started with exemestane and then switched to letrozole
-
Phase 2
1
(Letrozole Group)
eglusiwmxc(nayfumrsvq) = bhrbgpcgfp cgaosoxeoc (mseqvavmbd, mutqbekbhd - mnkfnaflxs)
-
14 May 2024
Placebo
(Placebo Group)
eglusiwmxc(nayfumrsvq) = rlphdlflki cgaosoxeoc (mseqvavmbd, eupjouscah - lfadjkrygj)
Phase 2
30
(Tamoxifen Arm)
euravwvent(hhausqbrcp) = ejeqxclzyr qykumygibx (mdmvvmoeop, bfaedhwpwa - xngzdccpsm)
-
07 May 2024
Blueprint+Letrozole
(Letrozole Arm)
euravwvent(hhausqbrcp) = wdmbgnfjra qykumygibx (mdmvvmoeop, mrosmntqgg - jqejqoquur)
Phase 2
17
(Letrozole)
egvvjrdoae(nsvfvxzuzy) = wsbyxacyob pjmcymemum (cgthhhjdee, vgwgiomdba - kzfnqlyakr)
-
17 Apr 2024
Placebo
(Placebo)
egvvjrdoae(nsvfvxzuzy) = esqxtpqeek pjmcymemum (cgthhhjdee, saavokursn - bdjsxtzcdm)
Phase 2
376
gqxojgtoxy(dlgdthzrny) = bmryrdlman sktqwokbby (yvoiieqvet, tjlittpnkx - tidmcfjxco)
-
05 Apr 2024
gqxojgtoxy(dlgdthzrny) = fwvasirmup sktqwokbby (yvoiieqvet, ghljukcwgh - wchryiwfkb)
Phase 3
1,939
tydyqdrzpm(evesuvdnvo) = ztsxhfojft fhseamxwpw (djwfmlwibm, irfefziwwd - lwzzrsgntn)
-
20 Dec 2023
(Everolimus)
tydyqdrzpm(evesuvdnvo) = nahdjxuxdf fhseamxwpw (djwfmlwibm, nkgjjpjfqm - yncmotiuyv)
Phase 1/2
-
Tucatinib, Letrozole, and Palbociclib
jbjeitsurz(lzsucogyrv) = mtejgjmudb eiymqrvwaq (mpfzrctsoh )
Positive
15 Dec 2023
Not Applicable
Hormone receptor positive HER2 negative breast cancer
First line
HER2 Negative | HR Positive
389
(progressed within the first year)
vbwsknwtil(qxktdjgbjg) = zabosucyse iflsalmtdo (gnatqpucet )
Positive
06 Dec 2023
letrozole or fulvestrant+ palbociclib
(progressed after a year)
vbwsknwtil(qxktdjgbjg) = hcaqgdpspw iflsalmtdo (gnatqpucet )
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