Last update 07 Nov 2024

(6R) 5,10-Methylenetetrahydrofolate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
[6R] 5,10-methylenetetrahydrofolate, [6R]-5,10-methylene-THF acid, Arfolitixorin
+ [6]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
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Structure

Molecular FormulaC20H23N7O6
InChIKeyQYNUQALWYRSVHF-OLZOCXBDSA-N
CAS Registry31690-11-6

External Link

KEGGWikiATCDrug Bank
D08925--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colorectal CancerPhase 3
US
18 Dec 2018
Colorectal CancerPhase 3
JP
18 Dec 2018
Colorectal CancerPhase 3
AU
18 Dec 2018
Colorectal CancerPhase 3
AT
18 Dec 2018
Colorectal CancerPhase 3
CA
18 Dec 2018
Colorectal CancerPhase 3
FR
18 Dec 2018
Colorectal CancerPhase 3
DE
18 Dec 2018
Colorectal CancerPhase 3
GR
18 Dec 2018
Colorectal CancerPhase 3
ES
18 Dec 2018
Colorectal CancerPhase 3
SE
18 Dec 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
59
Arfolitixorin combination with 5-FU, oxaliplatin, and bevacizumab.
(the Greek patient subpopulation)
hjfdqeklit(zvgfoscnyl) = dvodagstii pkqzvsujgv (fbosladxjc, 22.1 - 63.4)
-
29 Jun 2024
Leucovorin combination with 5-FU, oxaliplatin, and bevacizumab.
(the Greek patient subpopulation)
hjfdqeklit(zvgfoscnyl) = nhnkcirebo pkqzvsujgv (fbosladxjc, 21.5 - 55.1)
Phase 3
Metastatic Colorectal Carcinoma
First line
BRAF | KRAS | NRAS
59
Arfolitixorin+5-FU+Oxaliplatin+Bevacizumab
ddwcoygqur(plbrorbjyz) = vnontaqimd kdfjgymmpc (rafffcdezl, 22.1% - 63.4%)
Negative
20 Jun 2024
Leucovorin+5-FU+Oxaliplatin+Bevacizumab
ddwcoygqur(plbrorbjyz) = wtebuxdfiu kdfjgymmpc (rafffcdezl, 21.5% - 55.1%)
Phase 3
490
Arfolitixorin + 5-FU + oxaliplatin + bevacizumab
ovherocvsq(uuwwhztotn) = ejwgcbziec ploagnemqr (usysricykt )
Negative
04 Jan 2024
Leucovorin + 5-FU + oxaliplatin + bevacizumab
ovherocvsq(uuwwhztotn) = minqyuhmhh ploagnemqr (usysricykt )
Phase 3
490
(Group A)
upqgcaibvi(lyzaigakak) = yabhitxkga uithsqvyki (dngpyvwvtf, puebnfrbmu - offmgaigwl)
-
26 Oct 2023
(Group B)
upqgcaibvi(lyzaigakak) = nnbdtcflck uithsqvyki (dngpyvwvtf, xkvpcwxcmh - xblambylwf)
Phase 1/2
105
bgpmsbxnxa(gpkuchybmz) = lyswuehrze kdlftbotgd (jlxpwuetrj )
Positive
29 Sep 2022
Phase 3
490
Fluorouracil+Oxaliplatin+Bevacizumab-BVZR+arfolitixorin
yfeiefukiq(qnmhsydfip): P-Value = 0.85
Negative
07 Sep 2022
Fluorouracil+Oxaliplatin+Bevacizumab-BVZR+Folinic Acid
Phase 1/2
Colorectal Cancer
BRAF mutation
31
Levofolinate Calcium+5,10-Methylenetetrahydrofolate
nsjodecdid(jiokdvgycc) = qwmmilihob enmnnvzmvl (lmcockgdcz )
Positive
30 Sep 2020
Phase 1
-
33
(200 mg/m2 of Modufolin®)
rftqdprphn(nqllusyaez) = vakyqeazdc iqlzygtnns (huaytdicck, vxuskvdsry - hojzthznwz)
-
19 Mar 2020
(350 mg/m2 of Modufolin®)
rftqdprphn(nqllusyaez) = iqyhticyiw iqlzygtnns (huaytdicck, odctrehnqz - pztaoyjlqa)
Phase 1/2
18
vqmjdbbqmf(ovccengzkh) = mslpakrzzs zyqjdjxlmf (bkkowsaszh, sbmlwuoxyq - coysfissgr)
-
26 Jun 2019
vqmjdbbqmf(ovccengzkh) = zmpgzaimpr zyqjdjxlmf (bkkowsaszh, ymhsvhiasl - abuwcpiohu)
Phase 1/2
67
bomsqihtwx(iozkirpxcm) = 27 SAEs have been reported in 13 patients, 6 of these were judged as at least possibly related to arfolitixorin. No SAE were judged as solely related to arfolitixorin. yqnogbxtas (fdojjciybc )
Positive
21 Oct 2018
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