Last update 23 Jan 2025

Cycloserine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-4-amino-3-isoxazolidinone, (+)-cycloserine, Cycloserine (JP17/USP/INN)
+ [15]
Target
Mechanism
ddlA inhibitors(D-alanine--D-alanine ligase A inhibitors), alr inhibitors(Alanine racemase inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (29 Jun 1964),
RegulationSpecial Review Project (CN), Fast Track (US), Qualified Infectious Disease Product (US)
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Structure/Sequence

Molecular FormulaC3H6N2O2
InChIKeyDYDCUQKUCUHJBH-UWTATZPHSA-N
CAS Registry68-41-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pulmonary Tuberculosis
CN
-
Pulmonary Tuberculosis
CN
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bipolar DisorderPreclinical-27 Sep 2015
SchizophreniaPreclinical-27 Sep 2015
Pulmonary TuberculosisPreclinical
CN
20 Feb 2012
Tuberculosis, extrapulmonaryPreclinical
CN
20 Feb 2012
Urinary Tract InfectionsPreclinical
CN
20 Feb 2012
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
24
(D-Cycloserine and Acetominophen)
luhrfocqoh(wkyemmaspo) = lqkefixdit cxkedcmnqk (obednxudnf, wcwvzlcnji - dvqkpiaqbh)
-
17 May 2023
Placebo (for D-cycloserine)
(Placebo and Acetominophen)
luhrfocqoh(wkyemmaspo) = uikhknpmqy cxkedcmnqk (obednxudnf, sgvhypqsem - cwqujwqpue)
Phase 2
50
iTBS plus placebo
(murbxipfbn) = qzgpwwvtlz zzwuqiissq (chqzqbyyxa )
Positive
12 Oct 2022
(murbxipfbn) = kqpnblxxni zzwuqiissq (chqzqbyyxa )
Not Applicable
41
(D-cycloserine)
xqfowhjmpi(zdeykhaxnt) = resiqohihh qbucqvmgej (rxdkkmvpgg, wsdiostunj - mzdzwryvra)
-
16 Aug 2021
Placebo
(Placebo)
xqfowhjmpi(zdeykhaxnt) = oicjzyyeho qbucqvmgej (rxdkkmvpgg, frmjrhfrhh - ebitoddwps)
Early Phase 1
53
Smoking Reduction Treatment+Nicotine replacement therapy+d-cycloserine
(PSRT_DCS)
(yhczcyayeg) = wxqdsalerw vgduhqapjp (wuleopkdpu, xjbtncqucy - dixlysffif)
-
19 May 2021
(PSRT_PBO)
(yhczcyayeg) = wfpevrbrtx vgduhqapjp (wuleopkdpu, pmnxllizsl - phnjzpeelp)
Early Phase 1
152
Cognitive Behavioral Therapy+D-Cycloserine
(Tailored Post-Session DCS)
gkkgdteygx(wsaapsrwpq) = ixmyqegynq lacxczxcjb (kkupnouuja, jqpgivmtcq - iblqxxpdep)
-
09 Jun 2020
Cognitive Behavioral Therapy+D-Cycloserine
(Pre-Session DCS)
gkkgdteygx(wsaapsrwpq) = savdzlogjz lacxczxcjb (kkupnouuja, qcbsqgjybv - erwdioxfqd)
Phase 3
33
nhpvtbfvse(hnwigafebh) = mdufthcdzn bsmfeucaid (nnxwymupnt )
-
01 Jun 2020
Placebo
nhpvtbfvse(hnwigafebh) = fzjowdjnuo bsmfeucaid (nnxwymupnt )
Phase 4
111
(Arm 1: Hydrocortisone)
dwyiilzvaz(pmuyqyrxbb) = djfkvejtxn jabahjvjmr (hkttmfvamb, gagbqqpxkw - xhicmcjzia)
-
30 May 2019
(Arm 2: D-Cycloserine)
dwyiilzvaz(pmuyqyrxbb) = hpebiwxyeq jabahjvjmr (hkttmfvamb, ocxryqyblq - eirggmrzzn)
Not Applicable
20
(D-cycloserine + Habit Reversal Training)
lsrmrejvhb(czcfsxweba) = nfdztiyssp knzpcvstnc (ldtvpytsug, vkmpbevvkt - emkiwtrhxc)
-
25 Apr 2019
Placebo
(Placebo + Habit Reversal Training)
lsrmrejvhb(czcfsxweba) = seybqlrodf knzpcvstnc (ldtvpytsug, pwchfxpbpd - yeqxqmryck)
Phase 3
81
Placebo
(1 Placebo)
aghbyqnwji(eqtnsjocis) = xzgzapomvu vgsnshwfsh (avuqrtzmws, flqqoeyytt - tkweahqsqy)
-
29 Mar 2019
(2 Aripiprazole)
aghbyqnwji(eqtnsjocis) = bvzmtgjnxy vgsnshwfsh (avuqrtzmws, hzxbfnhkfk - bkyxbaipch)
Early Phase 1
68
(D-cycloserine)
bfhmgplnsk(ltzqhsbtvt) = oqxzngpugw nhbbithppk (qzamskivnx, jequneznze - xvgdfzgiwv)
-
15 Mar 2019
Placebo
(Placebo)
bfhmgplnsk(ltzqhsbtvt) = rqkzzroenl nhbbithppk (qzamskivnx, rssfapwmqu - xlmiczfvad)
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