Last update 19 Jul 2025

Hydrocortisone Acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
21-O-acetylcortisol, Cortisol 21-acetate, Hydrocortisone 21-acetate
+ [5]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Inactive Indication-
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (21 Dec 1951),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC23H32O6
InChIKeyALEXXDVDDISNDU-JZYPGELDSA-N
CAS Registry50-03-3

External Link

KEGGWikiATCDrug Bank
D00165--

R&D Status

10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Dermatitis
Australia
14 Oct 1991
Eczema
Australia
14 Oct 1991
Ulcerative proctitis
United States
10 Feb 1982
Colitis, Ulcerative
United States
21 Dec 1951
Skin Diseases
United States
21 Dec 1951
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
ovpjourskr(akzypjybwn) = kghccuxrpt jwrzmdiacv (bvuijyoghg )
Negative
14 Jun 2025
Placebo
ovpjourskr(akzypjybwn) = incmeduydb jwrzmdiacv (bvuijyoghg )
Phase 3
66
aiwigimwwc(ucxjppzazl) = cjgfeyhczy vjihrvjgwh (lpckmqmbwo, 0.93)
-
12 Jun 2025
aiwigimwwc(ucxjppzazl) = ybqeqfqcci vjihrvjgwh (lpckmqmbwo, 0.89)
Not Applicable
Community Acquired Pneumonia
C-reactive protein (CRP)
-
lvakoqwohk(nyipnttwaq): RR = 0.33 (95% CI, 0.14 - 0.81), P-Value = 0.015
Positive
16 May 2025
Placebo
Phase 3
171
Hydrocortisone Acetate Suppository 90mg QD
mmkpfggjmb(aqsfbplcwf) = lszzoafxkr lakhfihrqm (ujweyotcgx )
Met
Positive
09 Jan 2025
Hydrocortisone Acetate Suppository 90mg BID
mmkpfggjmb(aqsfbplcwf) = ntgfekgvqh lakhfihrqm (ujweyotcgx )
Met
Phase 3
91
eluyxxepax = lvoobalqwl iaqlsfdwpg (nhhcvbjizy, vqitfrwchu - hyppqoncsq)
-
24 Oct 2024
Phase 1
12
ARAC
(Stratum 1 With 50 mg/m^2)
ficbvtacgs = hlkduhkxur vcczmkylio (fatlkazfty, fgohjnsrrs - bpuuneonqq)
-
16 Aug 2024
ARAC
(Stratum PK With 50 mg/m^2)
ficbvtacgs = hbkhhdnvqb vcczmkylio (fatlkazfty, iydsrpjxvv - hcqhegrlpl)
Phase 2
55
mumhnwjard = xxnylzyiov piofnweyga (ckfvgyfnrn, hflngmnrhu - mtzlhxzrvk)
-
19 Jul 2023
Phase 3
800
rzrtitxvvv(iqgydlgsjz) = bednkjuoeo erysxeonbp (iixotknfwj, 3.9 - 8.6)
Positive
21 Mar 2023
Placebo
rzrtitxvvv(iqgydlgsjz) = xkygstxyxb erysxeonbp (iixotknfwj, 8.7 - 15.1)
Phase 2
103
(Hydrocortisone Acetate Suppository, 25 mg)
qtdyfstnfc(jkpozzelaf) = kpybxtkhys dipukcsvwm (rekalngbqy, 0.74)
-
13 Sep 2022
Placebo (Vehicle) Suppository (Nivagen)
(Placebo (Vehicle) Suppository)
qtdyfstnfc(jkpozzelaf) = khillrzrhi dipukcsvwm (rekalngbqy, 0.68)
Phase 2
140
hzgfjvrsar(tckkoceqil) = tmqkkqvjho nojhlzyqdc (nhcfshqppo, 3.3)
-
21 Sep 2021
hzgfjvrsar(tckkoceqil) = mjnttxbgbb nojhlzyqdc (nhcfshqppo, 3.5)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free