Drug Type Small molecule drug |
Synonyms 6-(2-Aminobenzo[d]oxazol-5-yl)imidazo [1,2-a]pyridine-3-yl morpholinomethanone, MLN1117, AGN-PC-0DB6FL + [5] |
Target |
Action inhibitors |
Mechanism PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC19H17N5O3 |
InChIKeyBLGWHBSBBJNKJO-UHFFFAOYSA-N |
CAS Registry1268454-23-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Endometrial Endometrioid Adenocarcinoma | Phase 2 | United States | 12 Dec 2024 | |
Advanced Malignant Solid Neoplasm | Phase 2 | - | ![]() | 01 Sep 2020 |
Colorectal Cancer | Phase 2 | - | ![]() | 01 Sep 2020 |
Endometrial Carcinoma | Phase 2 | - | ![]() | 01 Sep 2020 |
Head and Neck Neoplasms | Phase 2 | - | ![]() | 01 Sep 2020 |
Lung Cancer | Phase 2 | - | ![]() | 01 Sep 2020 |
PIK3CA mutant Breast Cancer | Phase 2 | - | ![]() | 01 Sep 2020 |
Metastatic Triple-Negative Breast Carcinoma | Phase 2 | United States | 18 Jul 2017 | |
Metastatic Clear Cell Renal Cell Carcinoma | Phase 2 | United States | 30 Jun 2016 | |
Metastatic Clear Cell Renal Cell Carcinoma | Phase 2 | Canada | 30 Jun 2016 |
Phase 1 | 19 | (Cohort 1) | zqknlqeevh = ledbmihfzg uffisrnwxh (wsamjmhqit, ebbxqdfgaf - uqiiimziyv) View more | - | 26 Jul 2024 | ||
(Cohort 2) | zqknlqeevh = arwjnxntva uffisrnwxh (wsamjmhqit, hoervhodkr - yvsgnyfery) View more | ||||||
Phase 2 | 12 | ygdojmopdu = sofzvwnsgg aeifnhuesa (okcnzjkide, ezwphacbmj - lawzfxdrqp) View more | - | 09 May 2023 | |||
Phase 1 | 19 | xzfuovljzj(qvybllfjlu) = kmwglrxhww ggxyycqdka (tijqbvckbe ) View more | Positive | 20 May 2021 | |||
Phase 2 | 96 | (Arm A: Single-agent Everolimus 10 mg QD) | yjlxhndded(iilmexnqtk) = xkgxeyhnxk cxuwtqrzup (hcxrfmtgfv, hiwkpedrro - nzrrgaczvd) View more | - | 21 Feb 2021 | ||
(Arm B: Single-agent MLN0128 30 mg QW) | yjlxhndded(iilmexnqtk) = dlrjctzvhj cxuwtqrzup (hcxrfmtgfv, kybwubivyw - ehwahvfmmn) View more | ||||||
Phase 2 | 241 | (Paclitaxel 80 mg/m^2) | dtaluhlwbb(kbhroxqpre) = oznrldesin hwqaveczrl (tttfuflzor, hajufohggg - vukkosbsqp) View more | - | 09 Jun 2020 | ||
(Paclitaxel 80 mg/m^2 + Sapanisertib 4 mg) | dtaluhlwbb(kbhroxqpre) = ufbzkergtx hwqaveczrl (tttfuflzor, iulbyfqtii - asfqmtzxlj) View more | ||||||
Phase 1 | 76 | ywrajnsacf(yrllwwdhzg) = gqdpfophll fuotpzaktb (ojmvqpnhuw ) View more | - | 20 May 2015 | |||
ywrajnsacf(yrllwwdhzg) = dmetqqfaxg fuotpzaktb (ojmvqpnhuw ) View more |