Drug Type Small molecule drug |
Synonyms 6-(2-Aminobenzo[d]oxazol-5-yl)imidazo [1,2-a]pyridine-3-yl morpholinomethanone, MLN1117, AGN-PC-0DB6FL + [5] |
Target |
Mechanism PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (US) |
Molecular FormulaC19H17N5O3 |
InChIKeyBLGWHBSBBJNKJO-UHFFFAOYSA-N |
CAS Registry1268454-23-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced Malignant Solid Neoplasm | Phase 2 | - | Petra Pharma Corp.Startup | 01 Sep 2020 |
Colorectal Cancer | Phase 2 | - | Petra Pharma Corp.Startup | 01 Sep 2020 |
Endometrial Carcinoma | Phase 2 | - | Petra Pharma Corp.Startup | 01 Sep 2020 |
Head and Neck Neoplasms | Phase 2 | - | Petra Pharma Corp.Startup | 01 Sep 2020 |
Lung Cancer | Phase 2 | - | Petra Pharma Corp.Startup | 01 Sep 2020 |
PIK3CA H1047R mutant Breast Cancer | Phase 2 | - | Petra Pharma Corp.Startup | 01 Sep 2020 |
Metastatic Triple-Negative Breast Carcinoma | Phase 2 | US | 18 Jul 2017 | |
Metastatic Clear Cell Renal Cell Carcinoma | Phase 2 | US | 30 Jun 2016 | |
Metastatic Clear Cell Renal Cell Carcinoma | Phase 2 | CA | 30 Jun 2016 | |
Metastatic Clear Cell Renal Cell Carcinoma | Phase 2 | CZ | 30 Jun 2016 |
Phase 1 | 19 | (Cohort 1) | kylmskvivx(fzlygucyrr) = qubxuilhma hgcusonmey (ddctegeuqw, varpdosnxk - vvdhoxoijh) View more | - | 26 Jul 2024 | ||
(Cohort 2) | kylmskvivx(fzlygucyrr) = xnmtvcuzjb hgcusonmey (ddctegeuqw, wgogyodmlt - lyvcicomlx) View more | ||||||
Phase 2 | 12 | agpauvqnnc(biiaxhijqp) = zgrccpiiwr kehyfqbdyk (vtvzeprmhs, ljgvcejpjw - wnbnbxzvym) View more | - | 09 May 2023 | |||
NCT03154294 (ASCO2021) Manual | Phase 1 | 19 | xcixaupohr(nhjzlknjlu) = seljbgcgki rhmfzbtcku (wwpbabhfzu ) View more | Positive | 20 May 2021 | ||
Phase 2 | 241 | (Paclitaxel 80 mg/m^2) | uitmlmkcrf(ieimoyqlaj) = byotklutng avphdtnebx (golzxiuafr, zhdrkwizhz - drzosrxzrb) View more | - | 09 Jun 2020 | ||
(Paclitaxel 80 mg/m^2 + Sapanisertib 4 mg) | uitmlmkcrf(ieimoyqlaj) = oboixlvskx avphdtnebx (golzxiuafr, eturfcyfrg - givhcyzbmn) View more | ||||||
Phase 1 | 76 | gdvgyydpsh(fciatoryyh) = zanttjwgjt ihbvyhhkjy (lemwjkbstd ) View more | - | 20 May 2015 | |||
gdvgyydpsh(fciatoryyh) = sgaebrtzaz ihbvyhhkjy (lemwjkbstd ) View more |