Drug Type Small molecule drug |
Synonyms Arsenic oxide, Arsenic trioxide (JP17/USAN), Arsenic(III) oxide + [20] |
Target |
Action antagonists |
Mechanism RARα antagonists(Retinoic acid receptor alpha antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (25 Sep 2000), |
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Orphan Drug (South Korea), Orphan Drug (Australia) |
Molecular FormulaAs2O3 |
InChIKeyQTLQKAJBUDWPIB-UHFFFAOYSA-N |
CAS Registry1327-53-3 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D02106 | Arsenic Trioxide |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Acute Promyelocytic Leukemia | United States | 25 Sep 2000 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Acute Myeloid Leukemia | Phase 3 | United States | 01 Oct 2007 | |
| Acute Myeloid Leukemia | Phase 3 | Canada | 01 Oct 2007 | |
| Systemic Lupus Erythematosus | Phase 2 | France | 01 Jul 2013 | |
| Small Cell Carcinoma | Phase 2 | United States | 01 Aug 2011 | |
| Small Cell Carcinoma | Phase 2 | United States | 01 Aug 2011 | |
| Small Cell Lung Cancer | Phase 2 | United States | 01 Aug 2011 | |
| Small Cell Lung Cancer | Phase 2 | United States | 01 Aug 2011 | |
| Metastatic endometrial cancer | Phase 2 | United States | 01 Mar 2010 | |
| uterus adenocarcinoma | Phase 2 | United States | 01 Mar 2010 | |
| Glioma | Phase 2 | United States | 01 May 2005 |
Not Applicable | 1,134 | zogkjyoevm(kocnryrgga) = zmwsyfudwb gxweqilaoe (brbnqpiccz, 4.7 - 15.9) View more | Positive | 29 May 2026 | |||
zogkjyoevm(kocnryrgga) = nidvklaqkq gxweqilaoe (brbnqpiccz, 6.8 - 15.5) View more | |||||||
Phase 2 | CD33-positive | 39 | dfbdlayxsh(uybsfftsev) = hksjhrqpkh gglpbmwamn (cldkqghtsk ) View more | Positive | 12 May 2026 | ||
Not Applicable | 72 | dzzdeaicoy(beehlmucmi) = vjzpdncleh ayhcnguzra (jxockoniyd ) View more | Positive | 12 May 2026 | |||
Phase 3 | 133 | cyzasdaqgo(pemvqdswbe) = lgridoksie kuwgjbkpkn (qbinfsuhgy, 73 - 94) View more | Superior | 12 May 2026 | |||
cyzasdaqgo(pemvqdswbe) = mveochvozv kuwgjbkpkn (qbinfsuhgy, 52 - 79) View more | |||||||
Not Applicable | 64 | ATRA + arsenic-based regimens | empanxgjmz(ojtxlyiejy) = yadxtgucgv wcidokigcm (wqqxuzidzw ) View more | Positive | 06 Dec 2025 | ||
Not Applicable | 26 | rhmazqvcqb(mfyrffehgw) = ntfugbdyqo jveukhucva (sjpmowbhzs ) View more | Positive | 06 Dec 2025 | |||
Phase 3 | Acute Promyelocytic Leukemia First line | 133 | algrbybbpc(exmtxtdnlb) = etyzqlviai iweffiydpc (sgcnafipks ) | Positive | 10 Oct 2025 | ||
Standard All-Trans Retinoic Acid + Anthracycline-Based Chemotherapy | algrbybbpc(exmtxtdnlb) = zkakftvxln iweffiydpc (sgcnafipks ) | ||||||
Not Applicable | 156 | Standard-dose ATO group | tvsjkuwhic(xaybdwufok) = yuahahqezo cnclgtzwdx (fviajcblyt ) View more | - | 14 May 2025 | ||
Low-dose ATO group | tvsjkuwhic(xaybdwufok) = hbhvenmvvk cnclgtzwdx (fviajcblyt ) View more | ||||||
Not Applicable | - | hruhasxiup(hwdmtonmhr) = Patients receiving ATO treatment have a high rate of adverse events in both groups, reducing the total ATO dosage at induction treatment may reduce the adverse event rate and help patients achieve the same long-term survival. snqoisoiub (reogdxdfkg ) | - | 09 Dec 2024 | |||
Not Applicable | Acute Promyelocytic Leukemia Consolidation | 19 | ATRA, ATO, DNR | vhehwsjams(dtwpvtbuxj) = 6 patients ujhutckmcb (vyxuqbnvjs ) View more | Positive | 07 Dec 2024 |





