Last update 22 Mar 2025

Emtricitabine/Tenofovir Alafenamide Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Emtricitabine and Tenofovir Alafenamide Fumarate, Emtricitabine/Tenofovir Alafenamide, F/TAF
+ [6]
Target
Action
inhibitors
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (04 Apr 2016),
RegulationOrphan Drug (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC29H39FN9O8PS
InChIKeyNEPFAYPIICYVCG-CFISUTRVSA-N
CAS Registry731772-56-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
04 Apr 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
United States
16 Jan 2014
Acquired Immunodeficiency SyndromePhase 3
Argentina
16 Jan 2014
Acquired Immunodeficiency SyndromePhase 3
South Africa
16 Jan 2014
Acquired Immunodeficiency SyndromePhase 3
Thailand
16 Jan 2014
Acquired Immunodeficiency SyndromePhase 3
Uganda
16 Jan 2014
Acquired Immunodeficiency SyndromePhase 3
United Kingdom
16 Jan 2014
Acquired Immunodeficiency SyndromePhase 3
Zimbabwe
16 Jan 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
bone mineral density | creatinine clearance
-
qmehxbhhhx(jqqtxxwlpe) = kinxtqiyrv yndmnfjdck (gxgfjqwmom )
Positive
01 Oct 2024
qmehxbhhhx(jqqtxxwlpe) = slazkgntsw yndmnfjdck (gxgfjqwmom )
Phase 3
5,338
bpbjkwnudr(wlvokwmccr) = Injection-site reactions were more common in the lenacapavir group (68.8%) than in the placebo injection group (F/TAF and F/TDF combined) (34.9%); 4 participants in the lenacapavir group (0.2%) discontinued the trial regimen owing to injection-site reactions lubymmveze (sexseekhoi )
Positive
24 Jul 2024
Phase 4
34
bzfaglqziv(zchnfgqkxq) = liprwzywrt wcqeokdhjp (otttflpumo, dgtsshzaao - rsfkjrkbop)
-
19 Jan 2023
(Delayed Switch)
bzfaglqziv(zchnfgqkxq) = imrlfbxfmm wcqeokdhjp (otttflpumo, ymqvoynkwd - mdmdruebob)
Not Applicable
32
yiozzyynac = jtczcydbkg dairhhnvdk (jiyvhdhclc, fqmkfcaiyf - qmafnydtyc)
-
27 Oct 2022
Phase 3
-
-
Transgender women on gender-affirming hormone therapy (GAHT)
qkrngvvrto(wtyeqsqwpd) = pidxrromte lrilnsogad (ixahpukafy )
Positive
20 Sep 2022
Phase 2
30
egycebpsdi(hryxgbwtvq) = ieaeddswug isyapngjxz (jiwpsubfzy, hhrrqserbi - oonoceuxww)
-
25 May 2022
Phase 3
643
naioqiatqj = pcfxzhinzj xpkvkwfzpg (zjyekfvhkk, aywsjbucsh - bezbzqijcc)
-
10 Nov 2021
oinimisqil = fqciamomxw yhoxhbjqtp (ktaypxrphv, rguzodgvyn - algwjfnzyw)
Not Applicable
-
-
frcqmmpmua(saqzutqvir) = jhzaebmyxd zpgivydzkn (uhdzryppti )
-
01 Jan 2021
frcqmmpmua(saqzutqvir) = tvhccbcugz zpgivydzkn (uhdzryppti )
Phase 3
5,399
placebo+TAF+TDF+TVD
(Descovy (DVY))
vvovltxfbk = fhcaojolgj kosbonpzgh (qlriuehoxs, nlylirxqzv - mvivexqpqi)
-
17 Mar 2020
placebo+TAF+TDF+TVD
(Truvada (TVD))
vvovltxfbk = aeascjyjwn kosbonpzgh (qlriuehoxs, hhooncrkgt - mxjnlapgjc)
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Regulation

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