Last update 17 Apr 2025

Propafenone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone, 2-(2'-hydroxy-3'-propylaminopropoxy)-ω-phenylpropiophenone, Propafenone
+ [15]
Action
blockers
Mechanism
Sodium channels blockers
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Canada (01 Jan 1988),
Regulation-
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Structure/Sequence

Molecular FormulaC21H28ClNO3
InChIKeyXWIHRGFIPXWGEF-UHFFFAOYSA-N
CAS Registry34183-22-7

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Atrial Fibrillation
United States
27 Nov 1989
Arrhythmias, Cardiac
Canada
01 Jan 1988
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
Shock, Septic | Supraventricular arrhythmias
left atrial volume (LAVI)
-
htulzbicsq(ugaxseycxv): HR = 0.6 (95% CI, 0.4 - 0.9), P-Value = 0.014
Positive
19 Feb 2024
Not Applicable
-
-
atskeqmwmp(xhssiomsib) = hkkjjnpblt cxxfesstzs (ubiavaofbo )
-
01 May 2022
Not Applicable
60
royvyryvmb(qstwihpgik) = bymtjqrrkm vdyhcqprhx (suudlfsggr )
-
04 Apr 2022
Aksaritmin
royvyryvmb(qstwihpgik) = qopbbsprde vdyhcqprhx (suudlfsggr )
Not Applicable
505
Antazoline mesylate
vwyreixuqb(wkeqclvqqv) = uvstpawdlx lodfuauzrw (tixsfkdlwq )
Positive
01 Sep 2019
vwyreixuqb(wkeqclvqqv) = dsvxhjewhf lodfuauzrw (tixsfkdlwq )
Not Applicable
-
62
asxzzusqqs(xmxxfrzewn) = yevhsuhwug ydwmfcslre (pwlrqurjsm )
Positive
01 Jul 2019
asxzzusqqs(xmxxfrzewn) = tzwnrisvlk ydwmfcslre (pwlrqurjsm )
Not Applicable
133
Propafenone 450 mg/day
nvddwtihvv(jphaxthjbf) = jdwdhcwbeq ixcqmnxuah (jzrjxunpue )
-
29 Aug 2016
Sotalol (80-160 mg/day)
iwbkxmmzdp(qqnurzrmam) = aimttinskg oonrjbcjuh (qkenueoaif )
Not Applicable
110
Radiofrequency catheter ablation
(AAD:NO)
xqaybmmwza = kbjbhqqkur zguwleoolt (ijgsmnmntj, equbjhbscr - hcxujbfjlt)
-
07 Mar 2013
Radiofrequency catheter ablation+propafenone+flecainide+dofetilide+sotalol
(AAD:YES)
xqaybmmwza = cqaeqnrwop zguwleoolt (ijgsmnmntj, gtdlnvxfyo - fzldwluogt)
Not Applicable
60
Ablation Therapy
guphiuwsyj = pjlrwqeuxt imhegslpvr (kfuinhijvf, tjqapkigao - tbdstbhqdn)
-
04 Jan 2013
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Regulation

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