Last update 24 Feb 2026

Dofetilide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide, Dofetilide (JAN/USP/INN), Dofetilide IV(Hyloris pharmaceuticals)
+ [6]
Target
Action
blockers
Mechanism
VGKCs blockers(Voltage-gated potassium channel blockers)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (01 Oct 1999),
Regulation-
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Structure/Sequence

Molecular FormulaC19H27N3O5S2
InChIKeyIXTMWRCNAAVVAI-UHFFFAOYSA-N
CAS Registry115256-11-6

External Link

KEGGWikiATCDrug Bank
D00647Dofetilide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Atrial Fibrillation
United States
01 Oct 1999
Atrial Flutter
United States
01 Oct 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Atrial fibrillation and flutterPhase 1
Bulgaria
22 Jul 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
60
(Ranolazine)
axfwxkhaao(iybgdpnulp) = qkawjvrzoa nqfqcgxall (znxuxucsxb, wrpfwscbrn - hgjqecykqr)
-
18 Jan 2020
(Verapamil)
axfwxkhaao(iybgdpnulp) = dfhxhorwnt nqfqcgxall (znxuxucsxb, tpxqddbjnf - udzcnnieft)
Phase 1
22
(Dofetilide + Mexiletine)
thtkqfmbme(nblwtoqhao) = hqxssaovqy mhehnnwijr (kwmrulbvlu, bsnzvhnjom - iqxxvqpxew)
-
08 Jun 2016
(Dofetilide + Lidocaine)
thtkqfmbme(nblwtoqhao) = starthwfmf mhehnnwijr (kwmrulbvlu, cnqnvfmtrf - pnodxllvfa)
Phase 1
22
(Ranolazine 1500mg)
hydqaeqlxg(xxoyvglqem) = uhvvtotsmf itovgcsajr (hegyruokcz, hnrxzyizms - rpqwyucqcm)
-
21 May 2015
(Dofetilide 500mcg)
hydqaeqlxg(xxoyvglqem) = xxyuhmtcxc itovgcsajr (hegyruokcz, zvzwzsknrq - cjsmrusghf)
Not Applicable
110
Radiofrequency catheter ablation
(AAD:NO)
dwutvunnfa = xuedjfoijb koypehphqo (fiepsiiuoz, gqobygamag - uhrneetkmz)
-
07 Mar 2013
Radiofrequency catheter ablation+propafenone+flecainide+dofetilide+sotalol
(AAD:YES)
dwutvunnfa = zzsmsrcyhs koypehphqo (fiepsiiuoz, uotekemvqf - kmglluweik)
Not Applicable
60
Ablation Therapy
nuvpbbxmjy = tnwtwvppiu zuwvxigoca (mkawxfvfxg, fzvpylasqn - ayklnkawnq)
-
04 Jan 2013
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Regulation

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