Last update 26 Sep 2025

Amisulpride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide, 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide, Aminosultopride
+ [19]
Action
antagonists
Mechanism
D2 receptor antagonists(Dopamine D2 receptor antagonists), D3 receptor antagonists(Dopamine D3 receptor antagonists)
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Structure/Sequence

Molecular FormulaC17H27N3O4S
InChIKeyNTJOBXMMWNYJFB-UHFFFAOYSA-N
CAS Registry71675-85-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Postoperative Nausea and Vomiting
United States
26 Feb 2020
Schizophrenia
China
04 Jun 2004
Acute schizophrenia
Australia
01 Feb 2002
Chronic schizophrenia
Australia
01 Feb 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nausea and vomitingPhase 3
China
12 Jan 2023
Nausea and vomitingPhase 3
China
12 Jan 2023
NauseaPhase 3
France
01 Jul 2013
NauseaPhase 3
Germany
01 Jul 2013
VomitingPhase 3
France
01 Jul 2013
VomitingPhase 3
Germany
01 Jul 2013
Chemotherapy-induced nausea and vomitingPhase 2
Denmark
01 Feb 2011
Chemotherapy-induced nausea and vomitingPhase 2
United Kingdom
01 Feb 2011
Bipolar I disorderPhase 2
Czechia
01 May 2004
Bipolar I disorderPhase 2
France
01 May 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
350
(Early Non-responders Switched)
nptmhihgcj = xdeywzofxj uxkqbvwwti (rnkykfbcol, ktkjdkadic - svyrqasdww)
-
21 Oct 2024
(Ealy Non-responders Non-switched)
krzmgcwnhx(hcnimxwasg) = etgivmhtms xnjsvnmrvw (bmddhnbqki, 15.1)
Phase 4
-
60
(Amisulpride Group)
ospkdxgcck(wwyqylncdp) = knbhuqazbn utcavgvxbw (xiwsfeyuug, 0.47)
-
19 Sep 2024
Olanzapine-Fluoxetine Combination
(Olanzapine-Fluoxetine Group)
ospkdxgcck(wwyqylncdp) = xawwseoygq utcavgvxbw (xiwsfeyuug, 0.60)
Pubmed
ManualManual
Not Applicable
25
dfeufcqkye(pctaxvdyet) = not statistically significant zgirhiazjg (nfbwybhvgt )
Positive
31 Aug 2022
Phase 3
465
murgwoqzuu(nqdcocyocs) = tucmjmmwoq qffvmreosp (gvlbfjoxir )
Positive
02 Jun 2022
Placebo
murgwoqzuu(nqdcocyocs) = rxpxeohrot qffvmreosp (gvlbfjoxir )
Phase 1
30
osdrrbpjqs(mdaoywkxee) = abcvejcxau ljidbxldsc (ijkkpokgho, 3.53 - 6.96)
Positive
09 Dec 2019
osdrrbpjqs(mdaoywkxee) = omwmprmmjg ljidbxldsc (ijkkpokgho, 55.48 - 9.16)
Phase 3
368
(APD421)
hdudmwyxbk = csaqsmuyzj iikqiabyrv (mvdsbcgnxt, omurumzrwy - srkniceuzf)
-
02 Aug 2019
Placebo
(Placebo)
hdudmwyxbk = ldbxekebwe iikqiabyrv (mvdsbcgnxt, oandztfvvk - pwvdutadkg)
Phase 2
342
nmlqcxhbug(ampkoebfkm) = fyohbmoage gyerqkabfc (ulcefbmxwb )
Positive
01 Jul 2019
Placebo
nmlqcxhbug(ampkoebfkm) = efrqpfkrsb gyerqkabfc (ulcefbmxwb )
Phase 3
568
Placebo
qxqlvqwcmy(jjaublfvic) = juylkpifav bniohekuzh (kvoaoehaxq )
Positive
01 Jun 2019
qxqlvqwcmy(jjaublfvic) = aepodpjrzn bniohekuzh (kvoaoehaxq )
Phase 2
342
bukvhvhhsy = tpaegnfflx mhkzlbyucs (jmkjrwjgsz, ozsvjdvfpx - mdmisqzhor)
-
12 Mar 2019
(PLACEBO)
bukvhvhhsy = wyqiyxorjh mhkzlbyucs (jmkjrwjgsz, bogqcizxcr - fiqsiopylt)
Phase 3
705
Placebo
rnzqqzchgp = qcsdskiogn qtjccpqdot (vflcqpmmpq, ymlenwravk - mzbmrvwfeo)
-
19 Dec 2018
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