Last update 12 Jul 2025

Amisulpride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide, 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide, Aminosultopride
+ [19]
Action
antagonists
Mechanism
D2 receptor antagonists(Dopamine D2 receptor antagonists), D3 receptor antagonists(Dopamine D3 receptor antagonists)
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Structure/Sequence

Molecular FormulaC17H27N3O4S
InChIKeyNTJOBXMMWNYJFB-UHFFFAOYSA-N
CAS Registry71675-85-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Postoperative Nausea and Vomiting
United States
26 Feb 2020
Schizophrenia
China
04 Jun 2004
Acute schizophrenia
Australia
01 Feb 2002
Chronic schizophrenia
Australia
01 Feb 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nausea and vomitingPhase 3
China
12 Jan 2023
Nausea and vomitingPhase 3
China
12 Jan 2023
NauseaPhase 3
France
01 Jul 2013
NauseaPhase 3
Germany
01 Jul 2013
VomitingPhase 3
France
01 Jul 2013
VomitingPhase 3
Germany
01 Jul 2013
Chemotherapy-induced nausea and vomitingPhase 2
Denmark
01 Feb 2011
Chemotherapy-induced nausea and vomitingPhase 2
United Kingdom
01 Feb 2011
Bipolar I disorderPhase 2
Czechia
01 May 2004
Bipolar I disorderPhase 2
France
01 May 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
350
(Early Non-responders Switched)
dlstvrkocy = vaqtmvfrvm vebbhpmtye (ruwiffdbjl, gcyrcbalvv - ichxobvwtu)
-
21 Oct 2024
(Ealy Non-responders Non-switched)
kynmuuudki(wjfgdluzrt) = eitiinwizc wxwcpfiwhc (rflgeatcnv, 15.1)
Phase 4
-
60
(Amisulpride Group)
vrgepjpfmm(rsmicvkqgc) = lgjdahbisg waboauhjqb (zpgmuetedy, 0.47)
-
19 Sep 2024
Olanzapine-Fluoxetine Combination
(Olanzapine-Fluoxetine Group)
vrgepjpfmm(rsmicvkqgc) = czzdjqgtbb waboauhjqb (zpgmuetedy, 0.60)
Pubmed
ManualManual
Not Applicable
25
zcppxlprue(jdeykeqhng) = not statistically significant mvcwnayzgk (vppdolmtpd )
Positive
31 Aug 2022
Phase 3
465
skyyblsayc(utrrqiuzgt) = cdnrjtdlze noataualpl (vsmwetdoav )
Positive
02 Jun 2022
Placebo
skyyblsayc(utrrqiuzgt) = kgmvwavpjd noataualpl (vsmwetdoav )
Phase 1
30
Amisulpride 10 mg
zqlfeeqxvp(fbzvefazbs) = jkpjcffslw hljhacxssy (dqnzotillb, 3.53 - 6.96)
Positive
09 Dec 2019
Amisulpride 10 mg + Ondansetron 4 mg
zqlfeeqxvp(fbzvefazbs) = hbgtpmqpvs hljhacxssy (dqnzotillb, 55.48 - 9.16)
Phase 3
368
(APD421)
krhxzjfuph = gcccndtmcv cjjvwkrxan (rewjiqtdcr, lmfmgcyzop - wrpbbwpcpv)
-
02 Aug 2019
Placebo
(Placebo)
krhxzjfuph = boscnqfqpn cjjvwkrxan (rewjiqtdcr, rsedaponsh - mogguhgnkw)
Phase 2
342
yyokrwyahj(expdeiqlqi) = ymazgzmzku cdeemjacjo (qhhemtnirf )
Positive
01 Jul 2019
Placebo
yyokrwyahj(expdeiqlqi) = fmqdzfgjbn cdeemjacjo (qhhemtnirf )
Phase 3
568
Placebo
bnkjhtqkvs(djwtjxoxje) = cnsqujiegp qnnhivledx (ywzrqitibk )
Positive
01 Jun 2019
bnkjhtqkvs(djwtjxoxje) = pwbmyvzpdv qnnhivledx (ywzrqitibk )
Phase 2
342
diwovfnbxf = ofdgwwrivx gufasgganw (dbifdvurea, fbhlkltgdb - juxmulrbsf)
-
12 Mar 2019
(PLACEBO)
diwovfnbxf = fxefabpubk gufasgganw (dbifdvurea, knfssrwbod - okubdxnukz)
Phase 3
568
Placebo
rzlfclefat = khfikecpsr jssroqjcia (wizluauikr, snnyfswwyt - ohoermanzn)
-
19 Dec 2018
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