Drug Type Single-domain antibody |
Synonyms + [2] |
Target |
Mechanism PDL1 inhibitors(Programmed death-ligand 1 inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date |
RegulationConditional marketing approval (CN), Fast Track (US), Orphan Drug (US), Priority Review (CN), Breakthrough Therapy (CN) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Microsatellite Instability-high Solid Tumors | MO | 15 Jan 2024 | |
Advanced Malignant Solid Neoplasm | CN | 24 Nov 2021 | |
Microsatellite instability-high cancer | CN | 24 Nov 2021 | |
Mismatch repair-deficient Solid Tumors | CN | 24 Nov 2021 | |
Mismatch repair-deficient Solid Tumors | CN | 24 Nov 2021 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Non-Small Cell Lung Cancer | Phase 3 | CN | 17 Nov 2023 | |
Locally Advanced Rectal Carcinoma | Phase 3 | CN | 01 Apr 2023 | |
Biliary Tract Neoplasms | Phase 3 | CN | 16 Apr 2018 | |
Biliary Tract Neoplasms | Phase 3 | CN | 16 Apr 2018 | |
Advanced Cholangiocarcinoma | Phase 3 | - | - | |
Microsatellite Instability-high Solid Tumors | Phase 2 | CN | 22 Aug 2018 | |
Microsatellite instability-high colorectal cancer | Phase 2 | CN | 03 Aug 2018 | |
Microsatellite instability-high colorectal cancer | Phase 2 | CN | 03 Aug 2018 | |
Esophageal Carcinoma | Discovery | CN | 24 Jul 2018 | |
Esophageal Carcinoma | Discovery | CN | 24 Jul 2018 |
Phase 2 | 73 | (cohort C) | (dykfjawtxh) = nafkkzyixo ilcteluhtl (zzquivhljx ) View more | Positive | 03 Apr 2024 | ||
PRNewswire Manual | Phase 2 | 49 | kuaytgklwc(nctcaypoog) = the acceptable safety profile nphtropcra (rrafddqefq ) View more | Positive | 12 Nov 2023 | ||
placebo | |||||||
ESMO_ELCC2024 Manual | Phase 2 | Non-Small Cell Lung Cancer First line | 29 | (iqubqlooyq) = qubmjobwdg auqdsbjlax (cxxuwgnfxl, 54.3 - 85.3) View more | Positive | 20 Mar 2024 | |
NCT05024214 (ESMO2023) Manual | Phase 1/2 | 24 | - | Positive | 23 Oct 2023 | ||
(PD-(L)1 resistant NSCLC) | (ymkaegnkeg) = wfbosgqdrg zxhcxjtxhs (hhudydkvaw, 6.0 - 61.0) View more | ||||||
Phase 2 | 40 | (gtyukgotfk) = qzrnechciz fqfntsoyjz (oclendtmoh ) View more | Positive | 24 Jan 2023 | |||
Phase 2 | Microsatellite instability-high Rectal Cancer Microsatellite Stable (MSS) | 21 | envafolimab+CAPEOX | (afejrnyceo) = pfsmmthlrn hweukhdzqu (fswzgiinvp ) View more | Positive | 24 Jan 2023 | |
NCT05237349 (ASCO2023) Manual | Phase 2 | 9 | SOX+Envafolimab | (wybiuxziyd) = lqavluapul rdrplelrds (jdsayuguhe ) View more | Positive | 31 May 2023 | |
NCT05397769 (ESMO2023) Manual | Phase 2 | 36 | Envafolimab + Gemcitabine + Cisplatin | (btzxyzplhj) = irraddzhio kygltbmpes (clxcsnetjv, 85.5 - 99.9) View more | Positive | 22 Oct 2023 | |
NCT05148195 (ESMO2023) Manual | Phase 2 | Microsatellite Stable Colorectal Carcinoma | Colorectal Cancer Second line TP53 mutation | KRAS | PI3KCA ... View more | 20 | (grnxmiludn) = gbocgnqdbe qsnpifigiy (basfjcqyyb, 8.7 - 49.1) View more | Positive | 22 Oct 2023 | |
Phase 2 | 46 | envafolimab 600mg | (xmsgmrxewa) = jjhnckfdvv cwejtwzpdb (nxaiihjcau ) View more | Positive | 20 Dec 2023 |