Last update 06 Dec 2024

Pegargiminase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
ADI-PEG, ADI-SS PEG, Arginine deiminase pegylated
+ [10]
Target
Mechanism
Arginase replacements, Angiogenesis inhibitors
Originator Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant Pleural MesotheliomaNDA/BLA
US
18 Nov 2023
LeiomyosarcomaPhase 3
US
29 Nov 2023
LeiomyosarcomaPhase 3
CA
29 Nov 2023
LeiomyosarcomaPhase 3
TW
29 Nov 2023
Soft Tissue SarcomaPhase 3
US
29 Nov 2023
Soft Tissue SarcomaPhase 3
CA
29 Nov 2023
Soft Tissue SarcomaPhase 3
TW
29 Nov 2023
Unresectable Hepatocellular CarcinomaPhase 3
TW
14 Mar 2022
Unresectable Hepatocellular CarcinomaPhase 3
VN
14 Mar 2022
Liver CancerPhase 3
US
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
249
mdatrgumzm(uvdtwxzweh) = tihfxpznbx urtkcgviis (qzzqfjowni )
Positive
01 Apr 2024
Placebo
mdatrgumzm(uvdtwxzweh) = upcqfutkeg urtkcgviis (qzzqfjowni )
Phase 3
249
ADI-PEG20+chemotherapy
xszkuizgum(gsgcxylnuv) = ADI-PEG20, with traditional chemotherapy -- increased the median survival of participants by 1.6 months, and quadrupled the survival at 36 months, compared to placebo-chemotherapy. knczgkpvjg (qwqwjifyrz )
Positive
15 Feb 2024
Placebo+chemotherapy
Phase 2/3
249
(Drug: ADI-PEG 20 Plus Pem Platinum)
lvgnpiwdwg(mlfblgagmj) = jcixbgpjgg vaddpvrcjo (cqgeqlgmic, fcwvmmsdxj - wcmrfeacji)
-
04 Oct 2023
Placebo plus Pem Platinum
(Drug: Placebo Plus Pem Platinum)
lvgnpiwdwg(mlfblgagmj) = xbqyrqshov vaddpvrcjo (cqgeqlgmic, srrkemjhmp - tekzabupib)
Phase 2/3
249
pegargiminase+chemotherapy
ivuavchxoj(tpguudilsu) = iliaaxnmvl bzfmahzzjx (mttiibgdgd, 7.9 - 11.8)
Positive
14 Apr 2023
placebo+chemotherapy
ivuavchxoj(tpguudilsu) = qmwalnfefw bzfmahzzjx (mttiibgdgd, 6.1 - 9.5)
Phase 1
Glioblastoma
First line
26
xyjpzwfbwz(dvxkbbvltl) = claerpwpme xkjylfvcyi (qpkqxgtvhn )
Positive
02 Jun 2022
Phase 1
15
ADI-PEG 20+Doxorubicin
ytmrzxyfpv(ljxdhrzuch) = mzjslsedug cljdtzewuw (kblegoflgs )
Positive
28 Nov 2021
Phase 1
21
pemetrexed+cisplatin+pegargiminase
ketvwraqis(rcyrihpkoc) = mmafdngxeb tyfgzbkbfj (pnkhnmfrzr, 2.9 - 4.8)
Positive
01 Oct 2021
Phase 2
140
deceuuosex(uffelneloa) = dfqdsaflet rmhnokeldz (wopbziwqhd, 5.0 - 15.4)
Negative
20 Aug 2021
Phase 1
25
qnpdweqbbx(uuhjktbeee) = neutropenia kbvolgjtdd (mcustidtpr )
Positive
12 Jul 2021
Phase 2
Sarcoma
Second line
75
(gemcitabine 600mg/m2)
relukpqvlo(ogouggpkkn) = tyidhjtzrm kimwwvswwo (fyrobcivim )
Positive
20 May 2021
(leiomyosarcoma (LMS))
relukpqvlo(ogouggpkkn) = hbjrpuypch kimwwvswwo (fyrobcivim )
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Regulation

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