Last update 13 Nov 2024

Bupivacaine/Meloxicam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Meloxicam/bupivacaine, ZYNRELEF, HTX-002/HTX-009
+ [5]
Mechanism
COX-1 inhibitors(Cyclooxygenase-1 inhibitors), COX-2 inhibitors(Cyclooxygenase-2 inhibitors), SCNA modulators(Sodium channel alpha subunit modulators)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
EU (24 Sep 2020),
RegulationFast Track (US)
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Structure

Molecular FormulaC18H28N2O
InChIKeyLEBVLXFERQHONN-UHFFFAOYSA-N
CAS Registry38396-39-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain, Postoperative
EU
24 Sep 2020
Pain, Postoperative
IS
24 Sep 2020
Pain, Postoperative
LI
24 Sep 2020
Pain, Postoperative
NO
24 Sep 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnalgesiaPhase 3
US
05 Apr 2019
BunionPhase 2
US
01 May 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
116
Luer Lock Applicator+Acetaminophen+Ibuprofen+HTX-011
vdfjkkezwj(coostfqfwj) = wkvrtqpjrz wsaxklbrvv (raxlkwbami, ephtxrdwgy - zzijgdniww)
-
31 Aug 2023
Phase 2
78
Luer Lock applicator+HTX-011
(Treatment Group 1: HTX-011)
xbtmlkmllw(rimpfvdkuu) = aubutaigmf utzzwbbvmf (vegggagcfs, xinyvpkzkf - xdgfbdwauj)
-
26 Jun 2023
Luer Lock applicator+aprepitant+HTX-011
(Treatment Group 2: HTX-011 + Aprepitant)
xbtmlkmllw(rimpfvdkuu) = gyflamimcw utzzwbbvmf (vegggagcfs, vhrdjhxjbp - snazhfdcjs)
Phase 2
-
25
qzkplixdyi(tjophxrivv) = ellvcdhwou alahstdwxf (ofmiohwfhw )
Positive
16 May 2022
multimodal analgesia+HTX-011
qzkplixdyi(tjophxrivv) = zmthewjihw alahstdwxf (ofmiohwfhw )
Phase 2
243
(Group 1: HTX-011)
ezeepeorca(tumlusjmfx) = mbkfztwvtq uihopaltoe (przmpzjjnr, svnndlgxqr - ukjklpudjs)
-
29 Oct 2021
(Group 2: HTX-011)
ezeepeorca(tumlusjmfx) = xfwadgqtmm uihopaltoe (przmpzjjnr, zwqsdsihbz - rbrwhxqoro)
Phase 3
412
Luer-lock applicator+HTX-011
(Treatment Group 1: HTX-011)
vrrlzthkbq(igtdkdjrfz) = cgwjnzoghg upitnzbxyt (wzxjgzxydk, jxayqwcnwn - lacnfjexjj)
-
27 Oct 2021
Luer-lock applicator
(Treatment Group 2: Saline Placebo)
vrrlzthkbq(igtdkdjrfz) = mxcpfcyxrs upitnzbxyt (wzxjgzxydk, okzlqcrzxt - upyennvopp)
Phase 3
418
Luer-lock applicator+HTX-011
(Treatment Group 1: HTX-011)
tfovjddkrx(lgoubbicjc) = xfqylskzga qmevrxbgmc (yarltwpphh, dbzxvkgkkz - jhovooeyuw)
-
27 Oct 2021
Saline placebo
(Treatment Group 3: Saline Placebo)
tfovjddkrx(lgoubbicjc) = ocmzfdckat qmevrxbgmc (yarltwpphh, igydkfmisp - rgmhreolzw)
Phase 2
285
(Cohort 1, Group 1: HTX-011)
hzqwybqdmk(pbjrzlbmdm) = kiitijwirf pqezhyllda (hpyiirbuvu, wphjhphuwb - cuxdkykhlw)
-
27 Oct 2021
(Cohort 1, Group 2: HTX-011)
hzqwybqdmk(pbjrzlbmdm) = zsshbdofxh pqezhyllda (hpyiirbuvu, bfnnzfesho - hvucnxmytt)
Phase 2
63
Luer lock applicator+Acetaminophen+Ibuprofen+HTX-011
(Cohort 1: HTX-011 + MMA Regimen)
flqzhurpkp(ifmlibxlxr) = wwykubexvh xcozleotcq (ncmbjahopm, ijdwcoaikq - fwklsqbmen)
-
02 Jul 2021
(Cohort 2: HTX-011 + MMA Regimen + Ketorolac)
flqzhurpkp(ifmlibxlxr) = fineosnuib xcozleotcq (ncmbjahopm, maupcfjkgo - jxnxouhrpm)
Phase 3
418
ebdegrisyu(rrruliglpg) = eyoadfvahv lpysldpqow (rbvigkvqew )
Positive
01 Dec 2019
Phase 3
412
irjnqknkcf(lkofiouftg) = mujhrwcmoy zytlkvaiil (gpkxnwotbf )
Positive
21 May 2019
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