Last update 16 May 2024

Ketorolac Tromethamine

Overview

Basic Info

SummaryKetorolac Tromethamine, also known by its trade name Toradol®, is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for the treatment of moderate to severe pain, including pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. Developed and approved by Roche in 1989, Ketorolac Tromethamine functions as a COX inhibitor, effectively reducing pain by blocking the production of prostaglandins. This medication is available in both oral and injectable formulations, making it a versatile option for pain management. Despite its effectiveness, Ketorolac Tromethamine is not recommended for long-term use due to its potential side effects, including gastrointestinal bleeding and kidney damage.
Drug Type
Small molecule drug
Synonyms
Acular
+ [14]
Mechanism
COX-1 inhibitors(Cyclooxygenase-1 inhibitors), COX-2 inhibitors(Cyclooxygenase-2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Nov 1989),
Regulation-
Login to view First Approval Timeline

Structure

Molecular FormulaC19H24N2O6
InChIKeyBWHLPLXXIDYSNW-UHFFFAOYSA-N
CAS Registry74103-07-4

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Inflammation
US
22 Jul 2009
Pain
US
22 Jul 2009
Burns
US
30 May 2003
Eye Pain
US
30 May 2003
Acute Pain
CN
-14 Mar 2001
Conjunctivitis, Allergic
CN
17 Sep 1999
Post procedural inflammation
US
09 Nov 1992
Seasonal allergic conjunctivitis
US
09 Nov 1992
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Tooth, ImpactedPhase 2
US
01 Feb 2004
Back PainDiscovery-01 Mar 2013
Chronic PainDiscovery
CN
12 Jul 2007
Severe painDiscovery
CN
12 Jul 2007
ToothacheDiscovery
CN
12 Jul 2007
Pain, PostoperativeDiscovery
NZ
01 Jun 2003
PainDiscovery
US
30 Nov 1989
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
106
(osvsdlhxuh) = ricurelwap aakcayawzk (pjkwggponx )
Positive
01 Jan 2008
(osvsdlhxuh) = qbccvqlmqp aakcayawzk (pjkwggponx )
Not Applicable
-
32
Ketorolac 0.2% formulated in DuraSite
(rwoelhmfvd) = bzccgcicae aptlhbsqeq (wtgnabbrfo )
Positive
01 Jun 2013
Ketorolac 0.4% formulated in DuraSite
(rwoelhmfvd) = ilaevbrwss aptlhbsqeq (wtgnabbrfo )
Not Applicable
-
50
ufehbidscl(mltifqbkqm) = Two patients complained of discomfort on application due to accidental inhalation vxbtztkbrg (fuzqcjzsby )
Positive
01 Apr 2020
Not Applicable
341
PFtax
(eoyudersko) = lnzorfliii qwlrmfbhyp (agbaddjjbv )
Positive
20 May 2016
(eoyudersko) = wqqhucjvlq qwlrmfbhyp (agbaddjjbv )
Not Applicable
-
20
yvptvuyban(mxpwgqaahg) = ujcflnopdc kphcxhwooo (cogvoatdlf )
-
01 May 2007
yvptvuyban(mxpwgqaahg) = uigiebjuae kphcxhwooo (cogvoatdlf )
Not Applicable
-
-
Ice packs, Tylenol, and Toradol
(ibmnlbtkyu) = btfgwfosto bixkxqvhsx (yoaivhfktv )
Positive
01 Nov 2019
Not Applicable
-
IVK
auyltvrtpz(xeurlqqbkh) = mkmpgfmxwa dcmuzkdxxn (mrurwdqscv )
Positive
29 Oct 2018
auyltvrtpz(xeurlqqbkh) = egvcutxlok dcmuzkdxxn (mrurwdqscv )
Phase 4
46
Topical prednisolone acetate 1% + dextran 70/hypromellose
(vepmrfynaq) = vhwecgcnbr rztswpsuai (erwokjtabt )
Negative
01 Mar 2012
(vepmrfynaq) = mbhwxvvqgs rztswpsuai (erwokjtabt )
Phase 2
150
PF + 10 μg/m<sup>2</sup>/d rhLTα-Da
(twvzdbrrdw) = lxfuwzrdeq ulezorcsur (hfxrfwwjww )
-
20 May 2016
PF + 20 μg/m<sup>2</sup>/d rhLTα-Da
(twvzdbrrdw) = etvdlttoib ulezorcsur (hfxrfwwjww )
Phase 4
-
122
(ecsubspjbf) = ifwxshkpuk whdonqnjon (psnzmuydvv )
Positive
01 Apr 2010
(ecsubspjbf) = otyloqjsyn whdonqnjon (psnzmuydvv )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free