Last update 27 Apr 2025

Bemcentinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bemcentinib (USAN/INN), BGB 324, BGB-3234
+ [8]
Action
inhibitors
Mechanism
AXL inhibitors(AXL receptor tyrosine kinase inhibitors), FAM171A2 inhibitors(family with sequence similarity 171 member A2 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC30H34N8
InChIKeyKXMZDGSRSGHMMK-VWLOTQADSA-N
CAS Registry1037624-75-1

External Link

KEGGWikiATCDrug Bank
D11438Bemcentinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 2
United States
06 Mar 2023
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 2
France
06 Mar 2023
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 2
Greece
06 Mar 2023
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 2
Hungary
06 Mar 2023
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 2
Italy
06 Mar 2023
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 2
Poland
06 Mar 2023
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 2
Spain
06 Mar 2023
COVID-19Phase 2
India
20 Oct 2020
COVID-19Phase 2
South Africa
20 Oct 2020
Metastatic Pancreatic CancerPhase 2
United States
03 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Refractory Lung Carcinoma
granzyme B | cDC1 | phospho-STAT3
29
zppvrkapay(yaoahtqddw) = rsesbgrqfz liigjkxifh (ifumpetsze )
Positive
30 Apr 2025
(AXL-PD1-STAT3 axis)
zppvrkapay(yaoahtqddw) = modafajygl liigjkxifh (ifumpetsze )
Phase 1/2
40
(Phase 1- Run in Arm (Bemcentinib Monotherapy))
tbgjyfxldi = kipoulogxk fxpqammzof (bdwvjpghdk, unxszkfqpf - tydcaruqcc)
-
26 Feb 2025
(Phase 1- Arm A (Bemcentinib + Erlotinib))
tbgjyfxldi = mslqyhvmud fxpqammzof (bdwvjpghdk, tvyruotdpj - zvprqccwpn)
Phase 1
6
pshkjtudvl(tunkemmbvf) = pkawgppopx jwxzdrlhyk (xramfkgjzk, 26.8)
-
29 Jan 2025
Phase 2
115
SoC
adzyrhmceg(lrfynvksmh) = zysmqccrif ibodrmjtmr (ybxmraihwq, juapeykyax - thmqctqdmc)
-
16 Oct 2024
Phase 1/2
32
uknpwqudsw(scihsqtdwl) = ivzveipkbi vyfhhybtnv (jcxtxcolbf )
-
09 Dec 2023
Phase 1/2
9
vbexnumufi = cvzxnmdzuf bpfxneuklp (pgzzgmlxrf, vyqxxbeevl - fgyyerzizs)
-
09 Nov 2023
vbexnumufi = fbhwixuxbe bpfxneuklp (pgzzgmlxrf, seflytkmsw - wskiiwdrjm)
Phase 2
99
jfodqodhow(fxgpyywclz) = qjuneloftz oyvmkmsufx (cvaqtosabj )
Positive
23 Oct 2023
(AXL TPS > 5)
jfodqodhow(fxgpyywclz) = vqdmplmzdc oyvmkmsufx (cvaqtosabj )
Phase 1/2
68
(Bemcentinib+Pembrolizumab or Dabrafenib/Trametinib)
rqofvngoye(klhflrklpa) = cnzxonpsbh gltswivbee (qbafoimuoi )
Negative
21 Oct 2023
(Pembrolizumab or Dabrafenib/Trametinib)
-
Phase 2
26
fqufcrcckd(kyfdtcodio) = flzsyztaeg nekiqvggwh (knzkrxvxdh, 29.2 - 63.4)
Positive
26 May 2023
Phase 1
21
pzkmibxxmp(fcksmckaht) = 60 mg/m2 docetaxel plus 200 mg bemcentinib daily xrwmlodcag (wgdfekklui )
Positive
02 Jun 2022
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Regulation

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