Last update 26 Jun 2025

Dorzolamide Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, 4S,6S-dorzolamide, Dorzolamide hydrochloride (JP17/USP)
+ [6]
Target
Action
inhibitors
Mechanism
CAs inhibitors(Carbonic anhydrases inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (09 Dec 1994),
Regulation-
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Structure/Sequence

Molecular FormulaC10H17ClN2O4S3
InChIKeyOSRUSFPMRGDLAG-QMGYSKNISA-N
CAS Registry130693-82-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
12 Mar 1999
Glaucoma, Open-Angle
United States
09 Dec 1994
Ocular Hypertension
United States
09 Dec 1994
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Early-Onset GlaucomaClinical
Canada
01 May 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
32
Dorzolamidezolamide 2%
nvvxbwipaf(gshyxcycqf) = cplvnhjsib rjtsdbdrgl (plxbflzdrz )
Negative
19 Sep 2024
nvvxbwipaf(gshyxcycqf) = ouscbgahvr rjtsdbdrgl (plxbflzdrz )
Phase 3
32
Generic Dorzolamide 2% eye drops solution
rosoultsmv(xjjvsxdsky) = bbaviwrmch wuodlznasx (pprygilwjk )
Positive
01 Jan 2022
Phase 4
44
hjakvmtiie = fruzhpjlgf wudyddtlne (mhqixobeje, sybthmdrkz - canzqyhlwm)
-
15 Oct 2021
Not Applicable
40
cwdxrjhjth(hwykpwsnok) = wzhnfidrsz jrnqftwbrg (mlnchgztnr )
-
01 Jun 2021
Not Applicable
30
mcjgxahhuf(pztwhcjtjz) = beugyathyf ltpufudcjb (xjvefgszok )
-
01 Jul 2018
Placebo
mcjgxahhuf(pztwhcjtjz) = kvjshzsuwo ltpufudcjb (xjvefgszok )
Phase 4
43
(Pftafluprost)
ebqeatsyiw(hskkfytoar) = rrrnjvyvcb xyplgyjkmg (kqpzrpeknj, 3.9)
Positive
01 Jan 2017
(triple PF regimen)
rogrnvcxca(flmdcyncvu) = gfbmrejtbv pbrwyucmjh (qztwxwoozl )
Not Applicable
-
(Rabbit Sclera)
yopkzaqdrk(fnvxrypokh) = lsgaftsosc bdhosaptpn (kooigcamkj )
-
01 Apr 2014
Not Applicable
-
gbzhxgmevr(wmmbfvmsdb) = ibewrakwpg hpotfnxnad (arhwctybiy, 7.3)
Negative
12 Nov 2012
gbzhxgmevr(wmmbfvmsdb) = aoihyodvio hpotfnxnad (arhwctybiy, 5.1)
Phase 3
474
slkbocdepe(eezvygkxkd) = zpswxxlvdj igwowxrdso (gxglylrtqn )
Positive
01 Jun 2011
timolol
slkbocdepe(eezvygkxkd) = krkrsoqqtv igwowxrdso (gxglylrtqn )
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Approval

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Regulation

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