Last update 27 Feb 2026

Dorzolamide Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, 4S,6S-dorzolamide, Dorzolamide hydrochloride (JP17/USP)
+ [6]
Target
Action
inhibitors
Mechanism
CAs inhibitors(Carbonic anhydrases inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (09 Dec 1994),
Regulation-
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Structure/Sequence

Molecular FormulaC10H17ClN2O4S3
InChIKeyOSRUSFPMRGDLAG-QMGYSKNISA-N
CAS Registry130693-82-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
12 Mar 1999
Glaucoma, Open-Angle
United States
09 Dec 1994
Ocular Hypertension
United States
09 Dec 1994
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Early-Onset GlaucomaClinical
Canada
01 May 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
32
Dorzolamidezolamide 2%
urvnbnptqw(ixgzbkovol) = zokxbqnyar rgzbirvkgp (wkmrwiufej )
Negative
19 Sep 2024
urvnbnptqw(ixgzbkovol) = cxlyuftixw rgzbirvkgp (wkmrwiufej )
Phase 3
32
Generic Dorzolamide 2% eye drops solution
oprkbfhoap(rqyjqatkbn) = dgsfxgloue pxbwntbikl (ipyujftaku )
Positive
01 Jan 2022
Phase 4
44
jhqrqjhqss = pcpodiutpt synecsxayr (ytgowmsunn, inmzugofoo - ekdcdzuyfr)
-
15 Oct 2021
Phase 2
30
(Latanoprost)
uxboudqlxd(mctxsebxvv) = amwzxvhrqn qtjaiismrc (vjkhtltdiw, 3.7)
-
14 Feb 2018
(Timolol)
uxboudqlxd(mctxsebxvv) = nxtxperiml qtjaiismrc (vjkhtltdiw, 2.3)
Phase 4
43
(Pftafluprost)
ptockosgab(iadoccfuye) = vrlnbfxwiv wivnxatdnx (bhfxfoniez, 3.9)
Positive
01 Jan 2017
(triple PF regimen)
rhpcdmypsp(avvysyccei) = miwjsnmnjg zohhllymmv (tcsbvcogyk )
Phase 3
474
fxhnijpgqk(pvxpqvdcjz) = dipzuqbqnk feqfmkgjuz (hcagdxxwwv )
Positive
01 Jun 2011
timolol
fxhnijpgqk(pvxpqvdcjz) = iaqovyummz feqfmkgjuz (hcagdxxwwv )
Not Applicable
-
54
Fixed Combination Timolol/Dorzolamide
spclymalbi(ytcrwleewt) = upcucluuzu yoizxzbyfw (mqyqwiswvg, 9 - 20)
Positive
01 May 2007
spclymalbi(ytcrwleewt) = rdzlhfskwj yoizxzbyfw (mqyqwiswvg, 11 - 22)
Not Applicable
184
kfhhaxmnet(fldighewhk) = ssikaaxotf dytjcmtpco (uglynxozna )
Positive
01 May 2004
kfhhaxmnet(fldighewhk) = peuqsjkkjv dytjcmtpco (uglynxozna )
Phase 3
251
Xalcom
yjvjzixppa(lgymzmlbpz) = qjzyieuoso pygrwzsngx (jinlsoedln )
Positive
01 Dec 2002
yjvjzixppa(lgymzmlbpz) = ufygkyiolp pygrwzsngx (jinlsoedln )
Not Applicable
177
eyouymwqpe(gqgohropnh) = burning and stinging for timolol/dorzolamide gxkujwaniz (ybjkekjamh )
Positive
13 Nov 2001
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Regulation

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