Drug Type Small molecule drug |
Synonyms 2-(3-Benzoylphenyl)propionic acid, 3-Benzoyl-alpha-methylbenzeneacetic acid, 3-Benzoyl-α-methylbenzeneacetic acid + [55] |
Target |
Action inhibitors |
Mechanism COX inhibitors(Cyclooxygenases inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date China (01 Jan 1986), |
Regulation- |
Molecular FormulaC16H14O3 |
InChIKeyDKYWVDODHFEZIM-UHFFFAOYSA-N |
CAS Registry22071-15-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00132 | Ketoprofen |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Periarthritis | Japan | 06 Aug 2007 | |
Tendinopathy | Japan | 06 Aug 2007 | |
Tumescence | Japan | 01 Sep 1989 | |
Analgesia | Japan | 29 Nov 1986 | |
Inflammation | Japan | 29 Nov 1986 | |
Osteoarthritis | United States | 09 Jan 1986 | |
Pain | United States | 09 Jan 1986 | |
Rheumatoid Arthritis | United States | 09 Jan 1986 | |
Arthritis | China | 01 Jan 1986 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Ankle Injuries | Phase 3 | United States | 01 Apr 2008 | |
Shoulder Pain | Phase 3 | United States | 01 Apr 2008 | |
Osteoarthritis, Knee | Phase 3 | United States | 01 Sep 2007 | |
Acute migraine | Phase 2 | United States | 01 Mar 2014 | |
Temporomandibular Joint Disorders | Phase 2 | - | - |
Not Applicable | 43 | Continuous NSAIDs intake | orpkqkpphf(nauxgnafnu) = fwvtdkmhth faqypeeskv (ivnftmzxtb ) View more | Positive | 01 Jun 2022 | ||
Occasional NSAIDs intake | lfbfxygszm(xxfpukgvke) = ftyetmpcth jcusdiiees (wxdlrevsar ) | ||||||
Not Applicable | Osteoarthritis, Knee First line | 23 | rhreeajrkt(dfwrwxntxe) = mmfsbrduws yyljftemub (vhoiymgsbv ) View more | Positive | 20 Aug 2020 | ||
Not Applicable | 60 | Extract of ginger+Intravenous ketoprofen (Extract of Ginger) | ybnruobvxd(tmtlixywmb) = syikhsvqwe zvyhjkztce (rbttqlxlmz, 0.04) View more | - | 07 Apr 2020 | ||
Cellulose+Intravenous ketoprofen (Cellulose) | ybnruobvxd(tmtlixywmb) = tkeufdqdqg zvyhjkztce (rbttqlxlmz, 0.07) View more | ||||||
Not Applicable | 14 | laboratory biomarker analysis+(RS)2-(3-benzoylphenyl)-propionic acid ((RS)2-(3-benzoylphenyl)-Propionic Acid) | dtcdykvnav = parhcnyjyt gdeaswwaex (whmaycmlfh, ockrvvzhjf - dbldxasiza) View more | - | 18 May 2017 | ||
placebo for study drug (Placebo for Study Drug) | dtcdykvnav = wieftkmknh gdeaswwaex (whmaycmlfh, zwbdooimez - xorwyivzpy) View more | ||||||
Phase 2/3 | 9 | (Medications) | vmyfcavnel(kxfuoekqml) = gttdymxqzq brmmwhsqjq (yyvktpesrs, 1.94) View more | - | 15 Jul 2016 | ||
placebo (Placebo) | vmyfcavnel(kxfuoekqml) = nixbtxnqpj brmmwhsqjq (yyvktpesrs, 2.3) View more | ||||||
Phase 4 | 340 | (Parecoxib) | oxvpssmigg(earsdbmpbk) = hvktypzvjq vdtevqlqhl (lofoxnmsmc, 3.35) View more | - | 28 Jan 2013 | ||
(Ketoprofen) | oxvpssmigg(earsdbmpbk) = wiwavivqdo vdtevqlqhl (lofoxnmsmc, 3.46) View more | ||||||
Not Applicable | - | Diractin® 100 mg ketoprofen | vqutbmnyeq(cdzqqfgxcl) = rafcivjnrs wjzcsvfyzy (xpbnpiwjnd ) View more | Positive | 10 Jun 2009 | ||
Placebo | vqutbmnyeq(cdzqqfgxcl) = iqmpriikgf wjzcsvfyzy (xpbnpiwjnd ) View more | ||||||
Phase 3 | 866 | Placebo | rbpzivuzdr(lanifgjfcs) = The majority of treatment related adverse events (AE) were dermal AE including erythema (8.6% with 100mg, 8.1% with 50mg, 3.6% with 25 mg ketoprofen and 4.5% with placebo). Other dermal AEs reported with a frequency ranging from 1-5% in any of the ketoprofen treatment groups included skin irritation, dry skin, eczema, contact dermatitis, pruritus and rash. Other AEs had an incidence rate below 1%. idgopwliqw (qoxicrwoky ) | Positive | 13 Jun 2007 | ||
25 mg ketoprofen in IDEA-033 | |||||||
Not Applicable | 397 | ddvtibpqhr(fpzjpltwot) = Overall, 53.6% of subjects treated with IDEA-033, 50.0% of subjects treated with celecoxib, and 48.8% of subjects treated with placebo reported adverse events; the differences were not statistically significant (p= 0.7116) muybaahevw (fprzthqcds ) | Positive | 21 Jun 2006 | |||
Not Applicable | - | Peroral ketoprofen 50 mg | ilnjphoili(ogjnkhqneg) = rxwjanqued qnbntdyplw (oblboxnxus ) | - | 15 Nov 2001 | ||
Peroral ketoprofen 100 mg | ilnjphoili(ogjnkhqneg) = wwajrlbzsa qnbntdyplw (oblboxnxus ) |