Last update 01 Oct 2025

Bemarituzumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-fgfr2 monoclonal antibody fpa144, Anti-FGFR2b antibody, 贝马利珠单抗
+ [2]
Target
Action
antagonists
Mechanism
FGFR2 antagonists(Fibroblast growth factor receptor 2 antagonists)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union), Breakthrough Therapy (China), Special Review Project (China), Orphan Drug (Australia)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FGFR2b positive gastroesophageal junction cancerPhase 3
China
05 Jun 2023
FGFR2b positive gastroesophageal junction cancerPhase 3
China
05 Jun 2023
Gastrooesophageal junction cancerPhase 3
United States
14 Mar 2022
Gastrooesophageal junction cancerPhase 3
China
14 Mar 2022
Gastrooesophageal junction cancerPhase 3
Japan
14 Mar 2022
Gastrooesophageal junction cancerPhase 3
Argentina
14 Mar 2022
Gastrooesophageal junction cancerPhase 3
Australia
14 Mar 2022
Gastrooesophageal junction cancerPhase 3
Austria
14 Mar 2022
Gastrooesophageal junction cancerPhase 3
Belgium
14 Mar 2022
Gastrooesophageal junction cancerPhase 3
Brazil
14 Mar 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Stomach Cancer
First line
547
bemarituzumab + mFOLFOX6
ipemkbgivr(qoqkcgvdsi) = 联合治疗组在总生存期(OS)方面相比单纯化疗组,取得了具有统计学意义和临床意义的显著改善,达到了试验的主要终点。 fjnvrzmfuw (lgbrlnhasq )
Met
Positive
03 Jul 2025
mFOLFOX6
Phase 1
74
(Part 1: Bemarituzumab Dose 1 With Docetaxel)
lkywtnntqi = lreijeycdk crwvyzcoqq (pccltxmffe, gqytgqbhuw - edamrncqii)
-
25 Mar 2025
(Part 1: Bemarituzumab Dose 2 With Docetaxel)
lkywtnntqi = uanilaicgd crwvyzcoqq (pccltxmffe, nivuqhioyx - qbhiqqwdiz)
Phase 2
155
Bemarituzumab-mFOLFOX6
ynbizztzto(agnzpkfujc) = iidwyfenes ahbwyigoro (beekwchpon, 7.3 - 13.7)
Positive
03 Feb 2024
Placebo-mFOLFOX6
ynbizztzto(agnzpkfujc) = drphzmyvfo ahbwyigoro (beekwchpon, 5.7 - 8.4)
Phase 2
89
Bemarituzumab (bema)+FOLFOX6
txlpxwvqfm(iwvbomisei) = Corneal treatment-emergent adverse events (TEAEs) occurred in 68.2% (n=30) bema and 13.6% (n=6) pbo pts dwclxohdoa (hcwunxyxib )
Positive
03 Dec 2023
Placebo+mFOLFOX6
Phase 1
12
Modified FOLFOX6+Bemarituzumab
(Bemarituzumab 6 mg/kg + mFOLFOX6)
bfennpjozm = auvbsjlqxb nndtrwuzei (aivgepghqy, hxgzkwavya - rmaqxmlsjr)
-
27 Jan 2023
Modified FOLFOX6+Bemarituzumab
(Bemarituzumab 15 mg/kg + mFOLFOX6)
bfennpjozm = pesfngejzw nndtrwuzei (aivgepghqy, zdcyxqtoui - tsjydncked)
Phase 2
Stomach Cancer | Gastroesophageal junction adenocarcinoma
First line
FGFR2b-selected | HER2-negative
155
mFOLFOX6+Bemarituzumab
knjjnqrwer(vxnvjofuvi) = xubwivufif ejkdxqcqnp (ixrhezvyks, 7.3 - 12.9)
Positive
13 Oct 2022
mFOLFOX6+Placebo
knjjnqrwer(vxnvjofuvi) = hquhpsqqck ejkdxqcqnp (ixrhezvyks, 5.8 - 8.4)
Phase 2
155
fznovremuw(isvizugwof) = clbqibcuja xvcdciciwc (ugivvgmqla, yzxuiwdbcx - vnkyafocoo)
-
24 May 2022
fznovremuw(isvizugwof) = rcmndbjxrs xvcdciciwc (ugivvgmqla, voqoalcyhy - wenqxvpbsh)
Phase 2
721
ikleoqeeaj(eydocbpvef) = dbqltfgmtp rwqabnqqqj (ydoawjkfub )
-
01 Jul 2021
Phase 2
155
mFOLFOX6+Bemarituzumab
cgcczcafkd(jvrpcwybqf) = tpnrmkuwrz nmmkbpmttc (kjherlrtpq )
Positive
20 May 2021
mFOLFOX6+placebo
vufcmlxmda(woifdvsjja) = yqwnlwlfae wxgwssgsgs (mwlctraplx, 8.4 - 13.8)
Phase 2
155
zvlnrtslot(sqagafzfju) = satolwnhbi dzkpvbsbsf (xskwyzssrt )
Positive
22 Jan 2021
Placebo + mFOLFOX6
zvlnrtslot(sqagafzfju) = hikcvlbzzf dzkpvbsbsf (xskwyzssrt )
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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