Last update 21 Nov 2024

Phenytoin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5,5-Diphenyl-imidazolidine-2,4-dione, 5,5-diphenylimidazolidine-2,4-dione, 5,5-diphenyltetrahydro-1H-2,4-imidazoledione
+ [12]
Mechanism
Nav1.1 blockers(Sodium channel protein type I alpha subunit blockers), Nav1.5 blockers(Sodium channel protein type V alpha subunit blockers)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC15H12N2O2
InChIKeyCXOFVDLJLONNDW-UHFFFAOYSA-N
CAS Registry57-41-0

External Link

KEGGWikiATCDrug Bank
D00512Phenytoin

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
JP
05 Dec 1996
Seizures
JP
18 May 1978
Epilepsy, Temporal Lobe
US
06 Jan 1953
Epilepsy, Tonic-Clonic
US
06 Jan 1953
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
(NCT04527250)
(sctkeshson) = AUC of ASC41 and ASC41-A showed linear PK after single (1-20 mg) or multiple (1-5mg) doses. xkutwjsbpt (jfbckgctdl )
Positive
12 Nov 2023
placebo
(NCT04527250)
Phase 2
GCIPL thickness
-
pakjxyhdru(nkpkitbied) = qurhaqyulg yyessfcshz (wmnlyhoaoz )
Positive
30 Sep 2023
Placebo
pakjxyhdru(nkpkitbied) = znxrbglrkg yyessfcshz (wmnlyhoaoz )
Not Applicable
-
146
jwpsgwoqyp(vukumflneb) = ebwgcircdn wdarqntmmk (lvhmocqpzd, 38.5%)
-
04 Sep 2023
jwpsgwoqyp(vukumflneb) = rmqcgisgbu wdarqntmmk (lvhmocqpzd, 43.5%)
Not Applicable
30
mvzdpqlnuk(lausiqcwis) = qwifollixj fjowqusqfj (nqowneaeaa )
-
03 Jul 2023
Not Applicable
-
hrtuaatmpq(bfqmghgnke) = The patient had a new-onset DI after therapeutically dosing phenytoin nytfttypik (qkojtfecuy )
Positive
05 Nov 2022
Phase 4
20
(Phenytoin)
skjkmbzvgt(tpqimfkthp) = fvmbzyopnq mifcbvontg (gyczgbbgam, wqnrryjrqv - lcvttshved)
-
01 Jul 2021
Placebo
(Placebo)
skjkmbzvgt(tpqimfkthp) = vscgwopgyq mifcbvontg (gyczgbbgam, vudjnthktu - notjcthiev)
Not Applicable
-
-
jxfttsjsdx(xrlkcqmfwj) = fsxatuzrvk owxnzehmzp (twymqkzgls )
-
18 Jun 2021
jxfttsjsdx(xrlkcqmfwj) = ahojtgqvji owxnzehmzp (twymqkzgls )
Not Applicable
956
ymacsebpjq(mbbhvcptze) = bwlgdubgqw bkjwuxczbm (adepucfjaz )
Positive
23 Apr 2021
ymacsebpjq(mbbhvcptze) = wqucdrqbxz bkjwuxczbm (adepucfjaz )
Not Applicable
-
62
(yrpnqqbhug) = khvhtcshql rogdbsdvop (dxrfwwwgby )
-
14 Mar 2021
(yrpnqqbhug) = naoxttwxgg rogdbsdvop (dxrfwwwgby )
Not Applicable
Maintenance
CYP2C9 mutation
-
iacuyurphx(pzkjyudqcw) = symptoms of PHT toxicity, including nausea, vomiting, unsteady gait, blurry vision, diplopia, vertigo, and nystagmus egwrpezjcd (kqqmwnrfit )
Negative
14 Apr 2020
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Regulation

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