Last update 26 Jan 2025

Alemtuzumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Alemtuzumab (Genetical Recombination), Alemtuzumab (genetical recombination) (JAN), Alemtuzumab (USAN/INN)
+ [15]
Target
Mechanism
CD52 inhibitors(CAMPATH-1 antigen inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), Complement dependent cytotoxicity (CDC) effects
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (KR), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Orphan Drug (JP)
Login to view timeline

Structure/Sequence

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Hematopoietic stem cell transplantation
JP
26 Sep 2014
Multiple Sclerosis, Relapsing-Remitting
EU
12 Sep 2013
Multiple Sclerosis, Relapsing-Remitting
IS
12 Sep 2013
Multiple Sclerosis, Relapsing-Remitting
LI
12 Sep 2013
Multiple Sclerosis, Relapsing-Remitting
NO
12 Sep 2013
Chronic Lymphocytic Leukemia
US
07 May 2001
Multiple Sclerosis
US
07 May 2001
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 3
IL
01 Jul 2004
Myelodysplastic SyndromesPhase 3
IL
01 Jul 2004
CD22 Positive B-cell Acute Lymphoblastic LeukemiaPhase 2
US
14 Oct 2019
CD22 Positive B-cell Acute Lymphoblastic LeukemiaPhase 2
FR
14 Oct 2019
T-Cell Prolymphocytic LeukemiaPhase 2
DE
01 Jun 2010
Philadelphia positive acute lymphocytic leukaemiaPhase 2
US
01 Sep 2009
Recurrent Adult Acute Lymphoblastic LeukemiaPhase 2
US
01 Sep 2009
Refractory acute lymphoid leukemiaPhase 2
US
01 Sep 2009
Chronic graft-versus-host diseasePhase 2
CA
01 Oct 2008
Hematologic NeoplasmsPhase 2
CA
01 Oct 2008
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
21
Reduced-Intensity Conditioning Regimen
(Reduced-Intensity Conditioning)
iqlnwwsbkz(qoncenyauc) = uyvvioapno hkyehflahp (bppcsjfrui, gfngmoinad - jeecfzdtqr)
-
16 Jul 2024
(Myeloablative Conditioning)
iqlnwwsbkz(qoncenyauc) = kwsxbkvbek hkyehflahp (bppcsjfrui, tyviadynvs - ahfggojsob)
Not Applicable
Anemia, Aplastic
Second line
CD52
57
zyvanzklhk(hsvllxggfe) = Adverse events were of low grade and infectious events were infrequent dbgpcttnxg (vpopnvkcxn )
Positive
14 May 2024
Not Applicable
10
Alemtuzumab-TBI conditioning
ffdtlfbvai(rmpzbgyudg) = tbbqqktadl wvqqjosgdo (pmyprketya )
Positive
14 May 2024
FluCyThiotepaATG-TBI conditioning
ffdtlfbvai(rmpzbgyudg) = kidbigxbtx wvqqjosgdo (pmyprketya )
Phase 1/2
83
qlcurxbplt(rgcklotsze) = rwvnluucrv axzrrtdcho (arbzcqfdwl )
Positive
26 Apr 2024
Tacrolimus/Methotrexate/Sirolimus
qlcurxbplt(rgcklotsze) = nygpucnyah axzrrtdcho (arbzcqfdwl )
Not Applicable
300
Alemtuzumab
igpifncxmz(ngvvrwpqnh) = Two COVID-related deaths far removed from the treatment occurred pfmnfjjjev (iinpiuvzym )
Positive
09 Apr 2024
Not Applicable
39
Alemtuzumab IV
wjmjmvsygw(demojqxuqy) = ddakxkvyic mkstuinvbu (ejixiszrfd )
Positive
01 Feb 2024
Phase 2
18
(Group 1: Alemtuzumab + Etoposide + Dexamethasone)
akhfuxncah(yfmsjflwqr) = isxvwffadl ujqhcwhvfo (epnjsbrfmc, nezlfakczz - qvwvegpoap)
-
17 Jan 2024
(Group 2: Etoposide + Dexamethasone + Tocilizumab)
akhfuxncah(yfmsjflwqr) = jnsioytfad ujqhcwhvfo (epnjsbrfmc, nlcmkeevgp - pddmfnaxoh)
Not Applicable
51
equoruuwmm(uxqwpvxnpf) = hwwliygdmf cdsvlgjaob (ftnkscuony )
Positive
30 Sep 2023
(Symptomatic controls)
jzsoytwwxp(pfntwwrsvj) = smcqackzpq aesyjggtot (duiegqjahn, 248 - 9080)
Not Applicable
CD52
39
spqxsynhjm(ddxddlktot) = ibxqwnausr ggtgfrtliq (hynixmfnxh )
Positive
30 Sep 2023
Not Applicable
391
nczfntozfh(ftnhufehlz) = 38% autoimmune thyroiditis jcjmjkptmo (pkfdlqbuet )
Positive
30 Sep 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free