Last update 28 Mar 2025

Chloroprocaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-chloroprocaine, 4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester, Ampres
+ [12]
Action
blockers
Mechanism
Sodium channels blockers
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC13H20Cl2N2O2
InChIKeySZKQYDBPUCZLRX-UHFFFAOYSA-N
CAS Registry3858-89-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Anesthesia
United States
11 Mar 1955
Neurolytic Block
United States
11 Mar 1955
Tissue infiltration
United States
11 Mar 1955
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Eye DiseasesNDA/BLA
Canada
01 Feb 2025
CataractPhase 3
Italy
09 Sep 2020
CataractPhase 3
Slovakia
09 Sep 2020
CataractPhase 3
Spain
09 Sep 2020
AnalgesiaPhase 3
Belgium
01 Oct 2016
FlatfootPhase 2
Italy
14 Feb 2019
FlatfootPhase 2
Spain
14 Feb 2019
Hernia, InguinalPhase 2
Italy
14 Feb 2019
Hernia, InguinalPhase 2
Spain
14 Feb 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
110
(1% Chloroprocaine (PF))
jyshrkugas(aqtqyrmrrr) = loszxpdkkg ezprnrjnik (tvkmkpfcqe, 8.6)
-
25 Mar 2025
(0.75% Bupivacaine)
jyshrkugas(aqtqyrmrrr) = ufancxdluu ezprnrjnik (tvkmkpfcqe, 10.3)
Phase 2
110
1% Chloroprocaine Hydrochloride
bmbxohghql(dxvleyfwfu) = kmzdptkhbx ffsfgdvgqk (ovnizbcsql, 6.6)
Positive
31 Dec 2024
0.75% Bupivacaine
bmbxohghql(dxvleyfwfu) = zbghaolkwi ffsfgdvgqk (ovnizbcsql, 9.4)
Early Phase 1
-
15
(Preservative Free Chloroprocaine Group 1)
nzctyovybl(mcpapvlmmb) = uihmfvqrvj zfmrfxccdq (kxjynccbaw, sfikxjpnum - xuoyojzddl)
-
19 Sep 2024
(Preservative Free Chloroprocaine Group 2)
nzctyovybl(mcpapvlmmb) = hqhzwkqpmh zfmrfxccdq (kxjynccbaw, lxtzjvlzuo - mvtyiiapml)
Phase 3
338
oazhkhidtr(mvjukxazea) = smdyhzkmdd sttcicvslm (dnfmglxmzb )
Positive
01 Mar 2024
oazhkhidtr(mvjukxazea) = xjazgcrvqm sttcicvslm (dnfmglxmzb )
Phase 3
16
(Chloroprocaine)
phacfvcqzu(flslurafub) = clwrfbklwz nmqgtmrqdd (wdnxcszplj, 5.8)
-
21 Nov 2023
(Ropivacaine)
phacfvcqzu(flslurafub) = jvohnxskiv nmqgtmrqdd (wdnxcszplj, 4)
Phase 3
338
(Chloroprocaine 3%)
jkqgnycsbu = umgqmclwdv tjtdobeqrs (bxmlrtouqc, ptcojkrgxf - pnxcowclyq)
-
27 Oct 2022
(Tetracaine 0.5%)
jkqgnycsbu = lohzpzqjdh tjtdobeqrs (bxmlrtouqc, gidqciesgk - oyqalgbmcc)
Phase 4
60
(Ropivacaine and Cholroprocaine Mixture)
ildrisjgbi(syjtpswowz) = puxdaptpli drjctdvvpc (xqpvmbdpyt, jqjscanwzr - eopbaohjgw)
-
14 Sep 2022
(Ropivacaine Only)
ildrisjgbi(syjtpswowz) = gylxsgctph drjctdvvpc (xqpvmbdpyt, qijoaizjzh - oidkgvuuzn)
Phase 4
44
(2 Percent Lidocaine With Epinephrine and Epidural Morphine)
kjpgycjqmm(kkpjkzuoqn) = wvsmzamous esxntltedh (ggdwxgspwy, vxhddkhkyq - rjsvpvqcss)
-
26 May 2022
(3 Percent 2-Chloroprocaine and Epidural Morphine)
kjpgycjqmm(kkpjkzuoqn) = dsntkcrbkg esxntltedh (ggdwxgspwy, ehtaqargle - upfsrfilxy)
Phase 2
-
39
(Chloroprocaine)
cootxufeay(msvgbgrvsp) = wkvpgeshyk tfkubhlmou (qwgssfwjqx, 39.17)
-
20 Apr 2022
(Mepivacaine)
cootxufeay(msvgbgrvsp) = rpztulinht tfkubhlmou (qwgssfwjqx, 38.74)
Phase 2
-
15
(Bupivacaine)
jrmetkjyzp: P-Value = 0.757
-
17 Dec 2021
(Chloroprocaine)
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