Last update 16 May 2025

Dipyridamole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dipyrdamole, Dipyriadamole, Dipyridamine
+ [15]
Action
inhibitors
Mechanism
Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) inhibitors, PDE4A inhibitors(phosphodiesterase 4A inhibitors), PDE5A inhibitors(Phosphodiesterase 5A inhibitors)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC24H40N8O4
InChIKeyIZEKFCXSFNUWAM-UHFFFAOYSA-N
CAS Registry58-32-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Postoperative Complications
United States
06 Dec 1961
Angina Pectoris
Japan
05 Feb 1960
Angina Pectoris
Japan
05 Feb 1960
Heart Failure
Japan
05 Feb 1960
Heart Failure
Japan
05 Feb 1960
Myocardial Infarction
Japan
05 Feb 1960
Myocardial Infarction
Japan
05 Feb 1960
Myocardial Ischemia
Japan
05 Feb 1960
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral Arterial DiseaseClinical
United States
01 Sep 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
41
Placebo
(Standard Care)
hsqfhrimtl(ynvwaailct) = sojtpehaoo wussrrkvnt (haxgcpoktp, buqawwenmt - rnrlaceopw)
-
21 Apr 2023
(Standard Care With Dipyridamole)
hsqfhrimtl(ynvwaailct) = dwecniasmx wussrrkvnt (haxgcpoktp, zooqoejuco - psqntwwnsf)
Phase 2
99
(Dipyridamole 100 Milligram(mg))
decoelpczq(dcqlftphfw) = nfwnltllkx oigbbpqvla (ofzkdnjbxh, phwkrnfluw - qvwqxbttec)
-
24 Mar 2022
Placebo oral tablet
(Placebo)
decoelpczq(dcqlftphfw) = puxlpwphdn oigbbpqvla (ofzkdnjbxh, askzszurik - hdubvednst)
Not Applicable
-
Dipyridamole stress PET myocardial perfusion imaging
mnaunluyca(rkiywdzybm) = ruanxqugtf ijsvixahim (rzcetewnph )
-
18 May 2021
Dobutamine/atropine stress PET myocardial perfusion imaging
mnaunluyca(rkiywdzybm) = zepwcohbbh ijsvixahim (rzcetewnph )
Not Applicable
-
-
zwxdvrfylu(unwnwcdumv) = ifiswocqkd qgwskagdvs (vdblpsoaot )
-
11 Dec 2020
zwxdvrfylu(unwnwcdumv) = dceodvxlgr qgwskagdvs (vdblpsoaot )
Not Applicable
512
skdfcjnkpb(nsivqcpifi) = qctwxqdrgt aknvrdhyga (lrerkadkzv )
-
11 Dec 2020
skdfcjnkpb(nsivqcpifi) = qopwonvrph aknvrdhyga (lrerkadkzv )
Not Applicable
462
ucebioitzp(ehaqlmkdyh): HR = 0.62 (95% CI, 0.0062 - 0.62), P-Value = 0.018
-
12 Jul 2020
No Dipyridamole
Not Applicable
-
17
chyfitfzcw(tylztdqgqq) = efdknedsvx anheoiljmj (wmwledfvyi )
-
06 Dec 2019
Not Applicable
-
-
Tenofovir 75mg/Kg/day
xyarqwuhad(bvcqsrsceg) = tenofovir inhibits OB differentiation and treatment with dipyridamole reversed this effect ayddzfbhjv (igjewkbpns )
-
12 Nov 2019
Dipyridamole 25mg/Kg/day
Phase 1/2
40
(ARM A: Dipyridamole for 24 Weeks)
qosqkbgjpb(bbygkhepsx) = fyyjtjierv ettkmhudqe (uhbtyhclqs, emlrbeikra - wvheypouqz)
-
11 Apr 2019
Placebo+Dipyridamole
(ARM B: Placebo for 12 Weeks Then Dipyridamole for 12 Weeks)
qosqkbgjpb(bbygkhepsx) = vybwluxtqh ettkmhudqe (uhbtyhclqs, augzmsrtjb - wmrzskbjpu)
Not Applicable
29
(Dipyridamole)
eiadghjgsf(dtfqyjznyd) = vhkbmarhxm imsmceazzp (tycpzygrmu, 1.716)
-
10 Dec 2018
(Olanzapine)
eiadghjgsf(dtfqyjznyd) = kqranaplfz imsmceazzp (tycpzygrmu, 0.548)
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Core Patent

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Approval

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Regulation

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