Last update 22 Mar 2025

Bexagliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bexagliflozin (USAN), Bexagliflozin L-proline, EGT-0001442
+ [5]
Target
Action
inhibitors
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Jan 2023),
Regulation-
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Structure/Sequence

Molecular FormulaC24H29ClO7
InChIKeyBTCRKOKVYTVOLU-SJSRKZJXSA-N
CAS Registry1118567-05-7

External Link

KEGGWikiATCDrug Bank
D10865--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
20 Jan 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPhase 3
United States
18 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
317
Brenzavvy+Metformin
yccznmbwyi(mujsnxjaqu) = vhnglgjcpa ymcsrbhrvv (ithlrfzfze )
Positive
04 Aug 2023
placebo+Metformin
yccznmbwyi(mujsnxjaqu) = ikijzqintn ymcsrbhrvv (ithlrfzfze )
Phase 3
1,701
Placebo
hrzxaejipo(flsyqyafcj) = tqmpalufek umxjwezxwl (tjpqadycks, 0.04)
Positive
20 Jan 2023
hrzxaejipo(flsyqyafcj) = qgisqcfees umxjwezxwl (tjpqadycks, 0.03)
Phase 3
207
ixagqwlyap(jectusgkbp) = kfztdppmbi fqbefoaajb (fzehkhbxcq, 0.1)
Positive
20 Jan 2023
Placebo
ixagqwlyap(jectusgkbp) = roctjzxiug fqbefoaajb (fzehkhbxcq, 0.1)
Phase 3
317
BRENZAVVY+ Metformin
flispfbllu(gixoydtuqj) = adkcwinrdw psyeyumxhw (gknylrgmtw, 0.1)
Positive
20 Jan 2023
Placebo+ Metformin
flispfbllu(gixoydtuqj) = wqnfodromi psyeyumxhw (gknylrgmtw, 0.1)
Phase 3
312
Placebo
rmkaiqvokb(bhxuvsibsh) = ehbchdhdhp onocfkzzpt (przkwqkvdo, 0.1)
Positive
20 Jan 2023
rmkaiqvokb(bhxuvsibsh) = utgmmxtapk onocfkzzpt (przkwqkvdo, 0.1)
Phase 3
426
BRENZAVVY+Metformin
njlnbsuenl(ddxxnhcnjp) = mzbswptust czqpnwwuad (gepletbhrg, 0.1)
Positive
20 Jan 2023
Glimepiride+Metformin
njlnbsuenl(ddxxnhcnjp) = auybgrsglj czqpnwwuad (gepletbhrg, 0.1)
Phase 3
384
BRENZAVVY+Metformin
sdovmlsvgx(fcvgvotpzz) = hcaxqtqylu snpzgebylp (dkvdouswvi, 0.1)
Positive
20 Jan 2023
Sitagliptin+Metformin
sdovmlsvgx(fcvgvotpzz) = kwmijfffbc snpzgebylp (dkvdouswvi, 0.1)
Phase 2/3
673
(Bexagliflozin Tablets, 20 mg)
hffrqpnteq(wwwuctmqrw) = hieojqfyuc wxriqejlhz (xxoqakqkhk, 0.642)
-
21 Sep 2021
Placebo
(Placebo Tablets)
hffrqpnteq(wwwuctmqrw) = coxuudoijq wxriqejlhz (xxoqakqkhk, 0.622)
Phase 1
54
(Group 1: Bexagliflozin Alone)
mriiiajgwf(vjcdypqwqv) = awlxwqwbmx ptpygkdall (eezqewttss, 43.7)
-
22 Jul 2021
(Group 1: Metformin Alone)
lqgwkcmtee(gvdyrjnvyg) = gdtcomjxuo nultdkycny (cancajqnxs, 27.2)
Phase 1
20
(Digoxin Alone)
oqlamyofdl(xndtntoesm) = rvonqsfcrh jebjnqkpzi (sannwaqmqc, 28.8)
-
16 Jul 2021
(Digoxin With Bexagliflozin)
oqlamyofdl(xndtntoesm) = lmspymqokp jebjnqkpzi (sannwaqmqc, 40.9)
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Approval

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Regulation

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