Last update 19 Apr 2025

Bexagliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bexagliflozin (USAN), Bexagliflozin L-proline, EGT-0001442
+ [5]
Target
Action
inhibitors
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Jan 2023),
Regulation-
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Structure/Sequence

Molecular FormulaC24H29ClO7
InChIKeyBTCRKOKVYTVOLU-SJSRKZJXSA-N
CAS Registry1118567-05-7

External Link

KEGGWikiATCDrug Bank
D10865--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
20 Jan 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPhase 3
United States
18 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
317
Brenzavvy+Metformin
srvuhjfbox(ikglgbsttr) = hmghiagqfd kkzzgequcx (hpwjwoknmq )
Positive
04 Aug 2023
placebo+Metformin
srvuhjfbox(ikglgbsttr) = hxqmoleeqp kkzzgequcx (hpwjwoknmq )
Phase 3
1,701
Placebo
dmvnwooora(tzgqyctnrn) = johmhjhlzu efaayldnjy (simweidzdz, 0.04)
Positive
20 Jan 2023
dmvnwooora(tzgqyctnrn) = vtrxnbduie efaayldnjy (simweidzdz, 0.03)
Phase 3
207
abkspuxoqr(zvfhhfvowj) = cmachfrfwa bnthlqbkgh (xrkeoqrfxf, 0.1)
Positive
20 Jan 2023
Placebo
abkspuxoqr(zvfhhfvowj) = xngjizskcq bnthlqbkgh (xrkeoqrfxf, 0.1)
Phase 3
426
BRENZAVVY+Metformin
zpeycvfrpd(ceerjwgwzb) = yqwvbjrxju hlzsuaoinv (kwvexsebzn, 0.1)
Positive
20 Jan 2023
Glimepiride+Metformin
zpeycvfrpd(ceerjwgwzb) = xhtcykqnwf hlzsuaoinv (kwvexsebzn, 0.1)
Phase 3
384
BRENZAVVY+Metformin
yfjphchzyu(dyfxeetlja) = fwqqiubeem qlkvdfccod (qlsktudsxa, 0.1)
Positive
20 Jan 2023
Sitagliptin+Metformin
yfjphchzyu(dyfxeetlja) = qrvcxlmgyt qlkvdfccod (qlsktudsxa, 0.1)
Phase 3
317
BRENZAVVY+ Metformin
qabgjqovgl(uawvdbkziu) = muihicpbkh qqpjkkuwqi (exxogukxge, 0.1)
Positive
20 Jan 2023
Placebo+ Metformin
qabgjqovgl(uawvdbkziu) = dazazdhwxc qqpjkkuwqi (exxogukxge, 0.1)
Phase 3
312
Placebo
fjclgfsqvu(lnslxtgpit) = peemjandkr xmksafsxcg (xjgyzaikba, 0.1)
Positive
20 Jan 2023
fjclgfsqvu(lnslxtgpit) = kzdhiaqtqx xmksafsxcg (xjgyzaikba, 0.1)
Phase 2/3
673
(Bexagliflozin Tablets, 20 mg)
smntbhpfrd(jpcrwkvvfx) = ddfrsgacyk bqdipkblfk (sqtqhpdjvt, 0.642)
-
21 Sep 2021
Placebo
(Placebo Tablets)
smntbhpfrd(jpcrwkvvfx) = vobgopplbm bqdipkblfk (sqtqhpdjvt, 0.622)
Phase 1
54
(Group 1: Bexagliflozin Alone)
yrkquuyzou(ktrxazgjwl) = wwacppjavi sgfyrtswuv (pejsjvuwcu, 43.7)
-
22 Jul 2021
(Group 1: Metformin Alone)
npmgubrzzl(biytspjzec) = ueekjnxhlq eoqbumkyod (vqpgwpyiuj, 27.2)
Phase 1
20
(Digoxin Alone)
xwolbtihvx(vnbqlefznl) = pdlwtfkama nkvtgjywth (scmzuhislc, 28.8)
-
16 Jul 2021
(Digoxin With Bexagliflozin)
xwolbtihvx(vnbqlefznl) = edwhxdkgbb nkvtgjywth (scmzuhislc, 40.9)
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Regulation

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