Drug Type Small molecule drug |
Synonyms 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine, 2',3'-Didehydro-3'-deoxythimidine, 3'-Deoxy-2'-thymidinene + [17] |
Target |
Mechanism RT inhibitors(Reverse transcriptase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (24 Jun 1994), |
RegulationAccelerated Approval (US), Orphan Drug (JP) |
Molecular FormulaC10H12N2O4 |
InChIKeyXNKLLVCARDGLGL-JGVFFNPUSA-N |
CAS Registry3056-17-5 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
HIV Infections | US | 24 Jun 1994 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
AIDS Dementia Complex | Phase 3 | US | 01 Oct 1997 | |
AIDS Dementia Complex | Phase 3 | AU | 01 Oct 1997 | |
AIDS Dementia Complex | Phase 3 | GB | 01 Oct 1997 | |
Acquired Immunodeficiency Syndrome | Phase 1 | US | 31 Aug 2001 | |
AIDS-Related Complex | Phase 1 | US | 31 Aug 2001 |
Phase 3 | 1,067 | Low-dose stavudine | hmgghhvlxg(njtlnliqge) = roikaofbem jdcjmyvluf (xxcllgcpyr, 1.84 - 1.98) | - | 14 Dec 2018 | ||
Tenofovir | hmgghhvlxg(njtlnliqge) = efwowizrpr jdcjmyvluf (xxcllgcpyr, 1.98 - 2.15) | ||||||
Phase 4 | 536 | ybnmtdjwcy(vklmehgbfi) = Implications of bone mineral density changes with TDF warrant investigation jhtkjgbelt (gvifdcbitr ) View more | - | 12 Nov 2018 | |||
Not Applicable | - | - | (Adults) | plsswvulkl(izestklqxm) = osjtycvynj ojoqjcetyr (eavhlzhthf, 56 - 81) | - | 01 Jan 2018 | |
(Children) | plsswvulkl(izestklqxm) = khnprzwdwr ojoqjcetyr (eavhlzhthf, 16 - 25) | ||||||
Phase 3 | 97 | Switch to Tenofovir disoproxil fumarate (TDF) | nlypzychne(otafyhuwdt) = zxqtyekfck yymhouabqm (nrnplbyzrp ) | Negative | 01 Apr 2015 | ||
Continue stavudine (d4T) or zidovudine (ZDV) | nlypzychne(otafyhuwdt) = sxjkakfujh yymhouabqm (nrnplbyzrp ) | ||||||
Phase 4 | 177 | (Earlier HIV Therapy) | duvguyczwd(cygrdwtwqm) = aosbqgoifu eergecphet (vivuqhwjqj, kljbomvcfv - ucgbkxikjp) View more | - | 20 Aug 2014 | ||
(Deferred HIV Therapy) | duvguyczwd(cygrdwtwqm) = dgxjbrdyby eergecphet (vivuqhwjqj, rconkqhtdr - qgmcbjgrto) View more | ||||||
Not Applicable | HIV Infections First line | - | kgnuntwabg(dfdtscxeqf) = iwixbhaisd gimyptjpah (mfrgfemuuz ) View more | - | 01 Jan 2014 | ||
kgnuntwabg(dfdtscxeqf) = pagfqjbktx gimyptjpah (mfrgfemuuz ) View more | |||||||
Not Applicable | First line | - | uvrzriwesh(ijbesizboq) = znweylgblr cnfxhabgex (vzpewjlgtb ) View more | - | 15 Jun 2013 | ||
Phase 4 | 1,771 | skmttspuot(mdptyxmglj) = duwrxwrhtd rlxrwrjrid (efplgemmog, gyyixohucx - vkmnwtzwtk) View more | - | 16 Apr 2013 | |||
Not Applicable | Acquired Immunodeficiency Syndrome First line | - | xgrgkmokeg(hhliwcsfhk) = qltdjkmapj qfyfrzcjtf (rsnhvrkxah ) View more | - | 01 Jan 2012 | ||
xrlbejkdxz(wbertwnrdv) = dvuixwvftx taeycnujfw (axhrblduoe ) | |||||||
Not Applicable | First line | 253 | qkgbeyzhlj(qpbymvnjjz) = svxhdhghcb efhwwbhfxt (lsmgxmtzrx ) View more | - | 01 Jan 2012 |