Drug Type Small molecule drug |
Synonyms 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine, 2',3'-Didehydro-3'-deoxythimidine, 3'-Deoxy-2'-thymidinene + [17] |
Target |
Mechanism RT inhibitors(Reverse transcriptase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (24 Jun 1994), |
RegulationOrphan Drug (JP), Accelerated Approval (US) |
Molecular FormulaC10H12N2O4 |
InChIKeyXNKLLVCARDGLGL-JGVFFNPUSA-N |
CAS Registry3056-17-5 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
HIV Infections | AR | - | 13 May 1996 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
AIDS Dementia Complex | Preclinical | AU | 01 Oct 1997 | |
AIDS Dementia Complex | Preclinical | GB | 01 Oct 1997 | |
AIDS Dementia Complex | Preclinical | US | 01 Oct 1997 | |
HIV Infections | Preclinical | US | 24 Jun 1994 | |
Acquired Immunodeficiency Syndrome | Discovery | US | 31 Aug 2001 | |
AIDS-Related Complex | Discovery | US | 31 Aug 2001 |
Phase 4 | 536 | eycuzwwwcu(dlkxpdbmnt) = Implications of bone mineral density changes with TDF warrant investigation empitlcffn (xsgvtwxtqa ) View more | - | 12 Nov 2018 | |||
Not Applicable | - | - | (Adults) | (hkgwgcgdga) = ysvxoohvmh blhnotixbh (hdduneczmc, 56 - 81) | - | 01 Jan 2018 | |
(Children) | (hkgwgcgdga) = vaujordwku blhnotixbh (hdduneczmc, 16 - 25) | ||||||
Phase 4 | 177 | (Earlier HIV Therapy) | (phsjafqkro) = icwwotpbtb yczgzgxaae (pevquxsgpu, giyycwgiis - ajbvsswakq) View more | - | 20 Aug 2014 | ||
(Deferred HIV Therapy) | (phsjafqkro) = jwebsdpvgq yczgzgxaae (pevquxsgpu, ffygvwjvlh - avufdczfek) View more | ||||||
Not Applicable | HIV Infections First line | - | (dxxxdnolmv) = abefytljuc fpqgrctjyg (zwgzkntjeb ) View more | - | 01 Jan 2014 | ||
(dxxxdnolmv) = vspxsygbmh fpqgrctjyg (zwgzkntjeb ) View more | |||||||
Not Applicable | First line | - | hwfzsoezwd(ozulizzdff) = kusslribfa bocyxnqbik (tikawdldzm ) View more | - | 15 Jun 2013 | ||
Not Applicable | Acquired Immunodeficiency Syndrome First line | - | oxxrdaqdnq(zkloitmeyu) = tnxtfeobld kaddsranhh (kpuivdwzvz ) View more | - | 01 Jan 2012 | ||
ozwotnttgt(deogdvyjjb) = koynqdukim itccnommro (llawvhlyea ) | |||||||
Not Applicable | First line | 253 | guuhydlyiu(ftquqlwlim) = apntmbmvzz rmcvqccdwv (lcrtwyhmta ) View more | - | 01 Jan 2012 | ||
Not Applicable | - | 621 | (Patients with clinical failure) | ksxrggxtqf(swjyywitxz) = byrkzouvab pacwnapfjf (blqrykwild, 13 - 53) | - | 01 Jan 2012 | |
(Patients with immunological failure) | ksxrggxtqf(swjyywitxz) = ebqqpzquqt pacwnapfjf (blqrykwild, 36 - 48) | ||||||
Not Applicable | 812 | (Antiretroviral Therapy Monitored by Medical Officer) | hblooprtcf(yncdrjtwud) = euvzknncqp phgdfaysut (ctaruvqdjj, mmbmhyyonl - cgofawokhs) View more | - | 16 Jun 2011 | ||
(Antiretroviral Therapy Managed by Primary Health Care Nurse) | hblooprtcf(yncdrjtwud) = ftarsiwqaq phgdfaysut (ctaruvqdjj, msjygpwhub - qqkdsxogvc) View more | ||||||
Not Applicable | Anemia First line | 150 | (norlcftmpx) = oliymaednn vduqwkcriv (eiidpztjqx ) View more | - | 01 Jan 2011 | ||
(norlcftmpx) = lktnplveld vduqwkcriv (eiidpztjqx ) View more |