Last update 21 Nov 2024

Stavudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine, 2',3'-Didehydro-3'-deoxythimidine, 3'-Deoxy-2'-thymidinene
+ [17]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (24 Jun 1994),
RegulationOrphan Drug (JP), Accelerated Approval (US)
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Structure

Molecular FormulaC10H12N2O4
InChIKeyXNKLLVCARDGLGL-JGVFFNPUSA-N
CAS Registry3056-17-5

External Link

KEGGWikiATCDrug Bank
D00445Stavudine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
AR
-13 May 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AIDS Dementia ComplexPreclinical
AU
01 Oct 1997
AIDS Dementia ComplexPreclinical
GB
01 Oct 1997
AIDS Dementia ComplexPreclinical
US
01 Oct 1997
HIV InfectionsPreclinical
US
24 Jun 1994
Acquired Immunodeficiency SyndromeDiscovery
US
31 Aug 2001
AIDS-Related ComplexDiscovery
US
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
536
eycuzwwwcu(dlkxpdbmnt) = Implications of bone mineral density changes with TDF warrant investigation empitlcffn (xsgvtwxtqa )
-
12 Nov 2018
Not Applicable
-
-
(Adults)
(hkgwgcgdga) = ysvxoohvmh blhnotixbh (hdduneczmc, 56 - 81)
-
01 Jan 2018
(Children)
(hkgwgcgdga) = vaujordwku blhnotixbh (hdduneczmc, 16 - 25)
Phase 4
177
(Earlier HIV Therapy)
(phsjafqkro) = icwwotpbtb yczgzgxaae (pevquxsgpu, giyycwgiis - ajbvsswakq)
-
20 Aug 2014
(Deferred HIV Therapy)
(phsjafqkro) = jwebsdpvgq yczgzgxaae (pevquxsgpu, ffygvwjvlh - avufdczfek)
Not Applicable
HIV Infections
First line
-
(dxxxdnolmv) = abefytljuc fpqgrctjyg (zwgzkntjeb )
-
01 Jan 2014
(dxxxdnolmv) = vspxsygbmh fpqgrctjyg (zwgzkntjeb )
Not Applicable
First line
-
hwfzsoezwd(ozulizzdff) = kusslribfa bocyxnqbik (tikawdldzm )
-
15 Jun 2013
Not Applicable
-
oxxrdaqdnq(zkloitmeyu) = tnxtfeobld kaddsranhh (kpuivdwzvz )
-
01 Jan 2012
ozwotnttgt(deogdvyjjb) = koynqdukim itccnommro (llawvhlyea )
Not Applicable
First line
253
guuhydlyiu(ftquqlwlim) = apntmbmvzz rmcvqccdwv (lcrtwyhmta )
-
01 Jan 2012
Not Applicable
-
621
(Patients with clinical failure)
ksxrggxtqf(swjyywitxz) = byrkzouvab pacwnapfjf (blqrykwild, 13 - 53)
-
01 Jan 2012
(Patients with immunological failure)
ksxrggxtqf(swjyywitxz) = ebqqpzquqt pacwnapfjf (blqrykwild, 36 - 48)
Not Applicable
812
(Antiretroviral Therapy Monitored by Medical Officer)
hblooprtcf(yncdrjtwud) = euvzknncqp phgdfaysut (ctaruvqdjj, mmbmhyyonl - cgofawokhs)
-
16 Jun 2011
(Antiretroviral Therapy Managed by Primary Health Care Nurse)
hblooprtcf(yncdrjtwud) = ftarsiwqaq phgdfaysut (ctaruvqdjj, msjygpwhub - qqkdsxogvc)
Not Applicable
Anemia
First line
150
d4T30mg+3TC150mg+NVP200mg followed by AZT250mg+3TC150mg+NVP200mg
(norlcftmpx) = oliymaednn vduqwkcriv (eiidpztjqx )
-
01 Jan 2011
(norlcftmpx) = lktnplveld vduqwkcriv (eiidpztjqx )
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Regulation

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