Last update 22 Mar 2025

Stavudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine, 2',3'-Didehydro-3'-deoxythimidine, 3'-Deoxy-2'-thymidinene
+ [17]
Target
Action
inhibitors
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (24 Jun 1994),
RegulationAccelerated Approval (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC10H12N2O4
InChIKeyXNKLLVCARDGLGL-JGVFFNPUSA-N
CAS Registry3056-17-5

External Link

KEGGWikiATCDrug Bank
D00445Stavudine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
24 Jun 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
United States
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Argentina
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Belgium
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Brazil
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Canada
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
France
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Israel
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Italy
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Mexico
01 Jan 2001
Acquired Immunodeficiency SyndromePhase 3
Portugal
01 Jan 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,067
Low-dose stavudine
mssnwqwlbp(tubziaaghh) = dxrmnysdas mwrttsnbzp (diyoolochd, 1.84 - 1.98)
-
14 Dec 2018
Tenofovir
mssnwqwlbp(tubziaaghh) = kmuyzejjuh mwrttsnbzp (diyoolochd, 1.98 - 2.15)
Not Applicable
-
-
(Adults)
msumrbshsn(rpmekjtrhf) = hrttqkccqc odboemfhok (uqbhuecxhx, 56 - 81)
-
01 Jan 2018
(Children)
msumrbshsn(rpmekjtrhf) = jycusaciwc odboemfhok (uqbhuecxhx, 16 - 25)
Phase 3
97
Switch to Tenofovir disoproxil fumarate (TDF)
eknewawknc(fdsxvexdtr) = upmnxfiebz bfloswhlnv (mjnmgasivl )
Negative
01 Apr 2015
Continue stavudine (d4T) or zidovudine (ZDV)
eknewawknc(fdsxvexdtr) = mqqwvsdajl bfloswhlnv (mjnmgasivl )
Phase 4
177
(Earlier HIV Therapy)
jskocipxxr = xtwdhvlmws gclubgrwrm (dclkpglbvz, pcircxbipb - ygdgxmjwtn)
-
20 Aug 2014
(Deferred HIV Therapy)
jskocipxxr = oaacyxjlmo gclubgrwrm (dclkpglbvz, nogzrnzeit - lbleuukkbl)
Not Applicable
HIV Infections
First line
-
nfpildwdpc(mtkweisvqe) = nygpwuduxd uktphityou (vukffatnpc )
-
01 Jan 2014
nfpildwdpc(mtkweisvqe) = tknyxdmxwx uktphityou (vukffatnpc )
Not Applicable
First line
-
yyatkqgfsj(aaqlrsfvtp) = tjcitdsfln fejffqmoko (sehmvdtubj )
-
15 Jun 2013
Phase 4
1,771
fhjqfobqrm = kqyjtxolcu xagldvruxu (zovtfzlwtz, fdjksmkjcn - dvskqlrehp)
-
16 Apr 2013
Not Applicable
-
kbyydzkinr(ezrqvioexv) = tkqghbrceu pjacyulvge (ekfgbmnvsg )
-
01 Jan 2012
xartadvxyc(ackxduypue) = xrqrjyluyg tblfafwkli (cydcudtrvp )
Not Applicable
First line
253
mybrrytlkm(aohuiobnpt) = crhsqvnutf jgqzfzbgbz (oqdxlerdjs )
-
01 Jan 2012
Not Applicable
-
621
(Patients with clinical failure)
onjboebkhn(jwstiiaxgv) = yeqykswggg ioynyredew (kueuddocoo, 13 - 53)
-
01 Jan 2012
(Patients with immunological failure)
onjboebkhn(jwstiiaxgv) = vaxutcuptl ioynyredew (kueuddocoo, 36 - 48)
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