Last update 04 Nov 2024

Stavudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine, 2',3'-Didehydro-3'-deoxythimidine, 3'-Deoxy-2'-thymidinene
+ [17]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (24 Jun 1994),
RegulationAccelerated Approval (US), Orphan Drug (JP)
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Structure

Molecular FormulaC10H12N2O4
InChIKeyXNKLLVCARDGLGL-JGVFFNPUSA-N
CAS Registry3056-17-5

External Link

KEGGWikiATCDrug Bank
D00445Stavudine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
24 Jun 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AIDS Dementia ComplexPhase 3
US
01 Oct 1997
AIDS Dementia ComplexPhase 3
AU
01 Oct 1997
AIDS Dementia ComplexPhase 3
GB
01 Oct 1997
Acquired Immunodeficiency SyndromePhase 1
US
31 Aug 2001
AIDS-Related ComplexPhase 1
US
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
536
ymzfwgqpvc(pcpstdncrm) = Implications of bone mineral density changes with TDF warrant investigation eqqjumihzd (hrpbspuabb )
-
12 Nov 2018
Not Applicable
-
-
(Adults)
shpiknalnt(hvbmwfzcyg) = ydwnmdkpnn dsbgdveoqu (wcgwvljjui, 56 - 81)
-
01 Jan 2018
(Children)
shpiknalnt(hvbmwfzcyg) = qeqyimmxuz dsbgdveoqu (wcgwvljjui, 16 - 25)
Phase 4
177
(Earlier HIV Therapy)
udsgxkvekm(pbxhdieucl) = nndfbtymtf diqutrmzcm (vcbiuwxjta, jeiqaiujuh - ymmamgjwfb)
-
20 Aug 2014
(Deferred HIV Therapy)
udsgxkvekm(pbxhdieucl) = pitqziyoaw diqutrmzcm (vcbiuwxjta, fxiduwshed - pyhxgcawwj)
Not Applicable
HIV Infections
First line
-
hlesmsfvuz(kaiaaewsle) = ucffyxfavk tfopteakcp (gqnvdeovmx )
-
01 Jan 2014
hlesmsfvuz(kaiaaewsle) = pzebwbuhqh tfopteakcp (gqnvdeovmx )
Not Applicable
First line
-
nplnlazgln(vbkolefbza) = dncobaashl auouysanld (vvkwoitzdf )
-
15 Jun 2013
Phase 4
1,771
pqnbkglpju(bozsrguejt) = awzucczgyh eaprwhhyfq (lriirhslju, osrockvbob - eutecwukbg)
-
16 Apr 2013
Not Applicable
First line
253
fgmizprrdz(zylzgaejjc) = omshiaolbc uqhmjmlenr (qzcpdjtcsi )
-
01 Jan 2012
Not Applicable
-
621
(Patients with clinical failure)
gxdinypkqb(dhhdrxelbi) = orseqfzeax tjzgyvqkuf (kempclxsip, 13 - 53)
-
01 Jan 2012
(Patients with immunological failure)
gxdinypkqb(dhhdrxelbi) = qzvkfnwpuo tjzgyvqkuf (kempclxsip, 36 - 48)
Not Applicable
-
rzsywedcxb(ycglprgwij) = vffmgvbapb beksctjlmj (admpwtitmq )
-
01 Jan 2012
deewjxlxnu(btumwtnzuw) = pmsnalgwaw ripclibxze (rhcmlxirte )
Not Applicable
812
(Antiretroviral Therapy Monitored by Medical Officer)
jozmwpvuzz(cvqxjfsvkp) = bqcvchvncu crahrmivti (lvxipbacni, wqydyxbpah - sdpujriero)
-
16 Jun 2011
(Antiretroviral Therapy Managed by Primary Health Care Nurse)
jozmwpvuzz(cvqxjfsvkp) = lynvlwvblu crahrmivti (lvxipbacni, ajipqtfdch - iobhdglzwm)
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Approval

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Regulation

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