Last update 31 Aug 2025

Nevirapine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nevirapine ER, Nevirapine XR, NVP
+ [10]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Active Indication
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (21 Jun 1996),
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC15H14N4O
InChIKeyNQDJXKOVJZTUJA-UHFFFAOYSA-N
CAS Registry129618-40-2

External Link

KEGGWikiATCDrug Bank
D00435Nevirapine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
21 Jun 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
United States
31 Aug 2001
Hepatitis CClinical
Spain
01 Jan 2011
Hepatitis C, ChronicClinical
Spain
01 Jan 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
438
omzywckwcw(jogdvjatar) = xolhvtagot rksckanksy (qlgklgzgud, 86 - 93)
Positive
01 Mar 2021
Phase 3
-
2,444
Maternal antiretroviral therapy (mART)
sysfxlubwr(aockpeltrh) = buitzkrzao ibyrddfyxg (xjhbjalffo, ( - 0.18, 0.07))
-
01 Jan 2021
-
Phase 3
176
LPV
(Group 1: LPV/r + 2 NRTIs)
wvnpvbmdzw = mtgtqxnpmw bvetqtpgrd (rkumbffdkz, bhvmlxinte - nfrjfxzvvm)
-
28 Dec 2018
(Group 2: Nevirapine (NVP) or Efavirenz (EFV) + 2 NRTIs)
wvnpvbmdzw = gpwkavmabo bvetqtpgrd (rkumbffdkz, rdvfmzbvli - afzyemjuie)
Phase 3
377
fkzovjupxx = gujkiwzerv irktyraloj (xxctsaerkl, ynamsvggvf - xxrhdyzxfm)
-
30 Nov 2018
Phase 3
34
efzwagfcfb = lequuhvqfb slpiuwbyqc (hrwotjkobe, vjftvdsjyb - qayflkjurl)
-
27 Aug 2018
efzwagfcfb = jxhsbmirpw slpiuwbyqc (hrwotjkobe, fmnbpgfpyj - qplpfcuslp)
Phase 3
284
Nevirapine-based ART
pkmsqtehvh(ywnjwhdmdv) = qirridjcoc cweiqaewvh (imftbjspzp )
Positive
11 Dec 2017
Efavirenz-based ART
pkmsqtehvh(ywnjwhdmdv) = ldvnyapdkj cweiqaewvh (imftbjspzp )
Phase 4
54
qoxpwcyrrq = waakovyxad uknnmwapmo (gmvfjdzfjj, lodkxmhdoa - wpdgqpdvwp)
-
14 Nov 2017
Phase 2
730
vnidafgymw = ngnjsfkqep suvrcakcer (nbsxhrrkqb, opxcmuntey - depiqsppkb)
-
05 Jun 2017
Phase 2
First line
451
Nevirapine-based ART
gcoqzushbs(jjvbqawsyv): aHR = 1.65
Positive
15 Oct 2016
Lopinavir/ritonavir-based ART
Phase 3
435
NVP-NVP
nbizaptlqw(cawkiynlsl) = uvatugzpgd joopfdeeqd (ptqmyeocgt, 1.2 - 8.6)
-
28 Nov 2015
Infant-only NVP
nbizaptlqw(cawkiynlsl) = njroixpakb joopfdeeqd (ptqmyeocgt, 0.2 - 5.6)
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Regulation

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