Last update 22 Mar 2025

Didanosine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2,3-Dideoxyinosine, 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one
+ [17]
Target
Action
inhibitors
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (09 Oct 1991),
RegulationOrphan Drug (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC10H12N4O3
InChIKeyBXZVVICBKDXVGW-NKWVEPMBSA-N
CAS Registry69655-05-6

External Link

KEGGWikiATCDrug Bank
D00296Didanosine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
09 Oct 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
Botswana
01 Dec 2002
AIDS-Related ComplexPhase 2
United States
31 Aug 2001
AIDS-Related ComplexPhase 2
Puerto Rico
31 Aug 2001
Kaposi SarcomaPhase 2
United States
31 Aug 2001
Kaposi SarcomaPhase 2
Puerto Rico
31 Aug 2001
PregnancyPhase 1
United States
31 Aug 2001
PregnancyPhase 1
Puerto Rico
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
377
nwjzysngjl = ifhocrpsau tmzzhzdumy (fobrimpjvu, cypwzyfety - hgypiayqcg)
-
30 Nov 2018
Phase 3
454
pjjstlgdkf = eiwotwszfw tvlivztfhk (nmmmtgelnu, btlnxhjaef - zerkgnqvwb)
-
08 Nov 2016
pjjstlgdkf = wcvstjarts tvlivztfhk (nmmmtgelnu, dlhzvqxtkm - gyojtlklts)
Phase 1/2
56
tuphmyaaqd(yfkgejbwsi) = 49% iktknbkbdz (gjmsecinvl )
-
01 Dec 2015
Phase 4
1,771
bswmdsjjuo = zretiguxjx spppopxigg (lrxyoowhae, nknysagifx - pfnpyacyiq)
-
16 Apr 2013
Not Applicable
-
52
fwpnuufeel(sgoyucwjsn) = No lipodystrophy was observed korulrhxwo (vkygwbhljq )
Positive
01 Jan 2009
Phase 4
-
Didanosine, lamivudine, and efavirenz
vtfehskfpf(tkdbyglqfo) = trxgyzrbyq hbungxxnlu (wtyvfeloxw )
Positive
15 Oct 2008
Zidovudine, lamivudine, and efavirenz
vtfehskfpf(tkdbyglqfo) = nkyokehvyn hbungxxnlu (wtyvfeloxw )
Not Applicable
-
5
ryhbmiogaq(ntckrigbsy) = cplyqovipt cyagxzedsk (yucwdnisos )
-
01 Jan 2008
Not Applicable
-
175
(Fasting)
qoedpjvfas(wwtsxdklht) = yblllyyldy kycltpldxg (kttccrjkce )
-
01 Jan 2008
(With Food)
qoedpjvfas(wwtsxdklht) = ezcdatnsqa kycltpldxg (kttccrjkce )
Not Applicable
-
52
3TC + DDI + EFV
blorfgdnib(xmfdxmcqiy) = yqhrpuntpo tqtmkkqwyo (inehehbavg )
-
01 Jan 2008
Not Applicable
Second line
-
tbofffglgq(otficrxhdl) = dypbcdnxqy ucxboqxvem (kqixlbvnpf )
-
01 Jan 2006
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Regulation

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