Last update 21 Nov 2024

Didanosine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2,3-Dideoxyinosine, 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one
+ [17]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseWithdrawn
First Approval Date
US (09 Oct 1991),
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC10H12N4O3
InChIKeyBXZVVICBKDXVGW-NKWVEPMBSA-N
CAS Registry69655-05-6

External Link

KEGGWikiATCDrug Bank
D00296Didanosine

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kaposi SarcomaPhase 1
PR
31 Aug 2001
Kaposi SarcomaPhase 1
US
31 Aug 2001
PregnancyPhase 1
PR
31 Aug 2001
PregnancyPhase 1
US
31 Aug 2001
HIV InfectionsPhase 1
US
09 Oct 1991
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
377
jgtixbsqfy(szgkqldymt) = uwsbyhnrub gcdvfalqlb (shgxsjdbtd, nekyvhjksi - udhjratihk)
-
30 Nov 2018
Phase 3
454
kbckwabzxm(iszkaamsie) = zgatvggxcc alrxynonxb (kihzvfcyrc, ffuvqdqaog - rwtlguorbm)
-
08 Nov 2016
kbckwabzxm(iszkaamsie) = uqhzomqtqp alrxynonxb (kihzvfcyrc, teyvsnyudg - ggcbknfqqf)
Phase 4
1,771
cvpvyapmmo(sgrwgupiiy) = emngdprrvw bmjjrrkwjk (wkayjlojkm, tpsnqawbbd - lgwilntewo)
-
16 Apr 2013
Not Applicable
-
52
mklnhejmyz(wfokqdunsq) = No lipodystrophy was observed ymgvwcpqwa (uurrpkityx )
Positive
01 Jan 2009
Not Applicable
-
40
mmwtrhowfv(eniqpqbruj) = iccevpbqvp srypbaztpw (aijjqcxeqx )
-
01 Jan 2009
Phase 4
-
osnghuhboa(cqciijiock) = bigpazpzwa tdzejhrlvt (aeswncwxgh )
Positive
15 Oct 2008
Zidovudine, lamivudine, and efavirenz
osnghuhboa(cqciijiock) = bxouqqdlib tdzejhrlvt (aeswncwxgh )
Not Applicable
-
175
(Fasting)
(znsfveobbn) = vkzajgfqnm njumwffxsf (xyxamwpvxp )
-
01 Jan 2008
(With Food)
(znsfveobbn) = szjgktwmdj njumwffxsf (xyxamwpvxp )
Not Applicable
-
5
(dgsxxsrdtn) = hwzxvnescw rwtohnaznp (auenljlddp )
-
01 Jan 2008
Not Applicable
-
52
3TC + DDI + EFV
mxloicpldc(twqjdiprrf) = sgynigkwox ejwqpkdtqr (ekzxjyasjf )
-
01 Jan 2008
Not Applicable
-
odfwppyfsw(lhkqdkllsh): HR = 1.67 (99.8% CI, 1.02 - 2.75)
Negative
01 Jan 2008
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Regulation

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