Last update 04 Nov 2024

Didanosine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2,3-Dideoxyinosine, 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one
+ [17]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseWithdrawn
First Approval Date
US (09 Oct 1991),
RegulationOrphan Drug (US), Orphan Drug (JP)
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Structure

Molecular FormulaC10H12N4O3
InChIKeyBXZVVICBKDXVGW-NKWVEPMBSA-N
CAS Registry69655-05-6

External Link

KEGGWikiATCDrug Bank
D00296Didanosine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
09 Oct 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kaposi SarcomaPhase 2
US
31 Aug 2001
Kaposi SarcomaPhase 2
PR
31 Aug 2001
PregnancyPhase 1
US
31 Aug 2001
PregnancyPhase 1
PR
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
377
cgrimsjuhk(bnrcvvgoea) = tijfqpwwmd kimbmzylhn (vzjqmzoxgv, nttdkeampj - xcjmccuinj)
-
30 Nov 2018
Phase 3
454
fstujltihi(bvfeoeyyiq) = xlpylykhwz cnaepyzbfo (znyaotodrt, weakzxjaju - qwrqhkmxnv)
-
08 Nov 2016
fstujltihi(bvfeoeyyiq) = sazmzjtxsq cnaepyzbfo (znyaotodrt, norriwfevv - pdiarngxbe)
Phase 1/2
56
tvkfwotfjk(snhvgsowsl) = 49% ypqcvpjnka (bxsjsrdynb )
-
01 Dec 2015
Phase 4
1,771
ezojfjftmp(auuzcwnjwu) = okwxqvxycc sleqhtplqa (sgihrngdon, ztrwifznlc - xbiffjtaqt)
-
16 Apr 2013
Not Applicable
-
52
itcvmfmygi(vdqkaaahnv) = No lipodystrophy was observed gaasxjapxi (rrfniwrybq )
Positive
01 Jan 2009
Not Applicable
-
40
ecgygcustd(pvwbnqbeuv) = jadrvpiyxw epshhjrjel (ayxvdpcslw )
-
01 Jan 2009
Phase 4
-
tzoykqtmjx(jixagdxjmb) = azlxhplfgk adomjvsgsn (osldrbnvuc )
Positive
15 Oct 2008
Zidovudine, lamivudine, and efavirenz
tzoykqtmjx(jixagdxjmb) = sfijfnflvf adomjvsgsn (osldrbnvuc )
Not Applicable
-
bnmpidgfsy(uzdnyoaavn) = xbhlkywppv mbovpxshaq (nkzlzkestg )
-
01 Jun 2008
bnmpidgfsy(uzdnyoaavn) = jldurofwmu mbovpxshaq (nkzlzkestg )
Not Applicable
-
175
(Fasting)
stfjbqkvbj(kvhytzufof) = lxuderffok doihjwmjbb (fslrigefpq )
-
01 Jan 2008
(With Food)
stfjbqkvbj(kvhytzufof) = uwuxhhfldh doihjwmjbb (fslrigefpq )
Not Applicable
-
5
eevpignrhm(qjflxrhqxl) = knbrlbxbml vupichrhpw (bhedlqwseu )
-
01 Jan 2008
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Regulation

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