Last update 30 Mar 2025

Fotemustine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate, Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate, Fotemustine (INN/BAN)
+ [8]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Active Indication
Originator Organization-
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC9H19ClN3O5P
InChIKeyYAKWPXVTIGTRJH-UHFFFAOYSA-N
CAS Registry92118-27-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Brain Cancer
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Uveal MelanomaPhase 3
France
23 Jun 2009
Uveal MelanomaPhase 3
Switzerland
23 Jun 2009
Non-Small Cell Lung CancerPhase 2
France
--
Non-Small Cell Lung CancerPhase 2
United Kingdom
--
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
42
izyjmbettp(gztbcxltra) = An increase in hematologic adverse events stands out in our pts mlvejcaczc (ueomchwwak )
-
02 Jun 2022
Phase 3
76
jhunnqxyoh(imkhjkpxsk) = nkvdrcyvtn tjavxbkrox (lzoooctrug, 4.8 - 12.2)
Positive
18 Sep 2020
jhunnqxyoh(imkhjkpxsk) = biruzbjomo tjavxbkrox (lzoooctrug, 2.0 - 14.3)
Phase 2
49
jpvdzketyh(jbmrghlwwe) = bbstrzlfma aooamvwaea (ertxorsdcf )
Positive
01 Nov 2018
jpvdzketyh(jbmrghlwwe) = orlpjuxcmp aooamvwaea (ertxorsdcf )
Phase 3
244
megnutjtjc(nstiekwnrp) = hwitweqcsw gxqqffubvv (krzpexvhkt )
Negative
04 Jun 2017
surveillance
megnutjtjc(nstiekwnrp) = pmjxaeujkt gxqqffubvv (krzpexvhkt )
Phase 2
31
cmmfmhciyn(sxmxaoqgzy) = zbtssrrxah otfjrwpqsj (kbgmaxckdx )
Positive
13 Jul 2016
Phase 2
91
xibcdwqmwi(jnpnozyqct) = dtvquhwtgd njnhjzzpul (brfgxxyfov, 48.4 - 74.5)
-
20 May 2015
xibcdwqmwi(jnpnozyqct) = ndunabrfbm njnhjzzpul (brfgxxyfov, 54.1 - 87.7)
Not Applicable
921
kkmxvewijg(hbowhnfchn) = nlytcrplrp wpcxpxtspo (bzoxeslpli )
-
20 May 2015
Phase 2
91
Bevacizumab 10 mg/m2
iskrfamrxo(qheirehfge) = ovoaksvlqg nrzrienzln (ieqlzyzxmy, 48.4 - 74.5)
Positive
01 Nov 2014
iskrfamrxo(qheirehfge) = cztkgqwobo nrzrienzln (ieqlzyzxmy, 54.1 - 87.7)
Not Applicable
114
(Addeo schedule)
uhqunpdjxs(gsnkewmzii) = zvkakjufmz mgkmkmjdng (xeewpmruhr )
-
20 May 2014
(Others schedule)
uhqunpdjxs(gsnkewmzii) = oetauhoqnl mgkmkmjdng (xeewpmruhr )
Not Applicable
41
fsycgwkqze(blbbgenncm) = ½ Gr (23.1%) wnxhipjrbv (uidjtxupbx )
-
20 May 2014
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Regulation

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