Last update 21 Nov 2024

Dactinomycin

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide, ActD, Actinomycin
+ [17]
Target
Mechanism
DNA inhibitors(DNA inhibitors)
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC62H86N12O16
InChIKeyRJURFGZVJUQBHK-IIXSONLDSA-N
CAS Registry50-76-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ewing Sarcoma
JP
15 Sep 2005
Rhabdomyosarcoma
JP
15 Sep 2005
Hodgkin's Lymphoma
CN
01 Jan 1995
Neuroblastoma
CN
01 Jan 1995
Testicular Neoplasms
CN
01 Jan 1995
Choriocarcinoma
JP
16 Dec 1968
Wilms Tumor
JP
16 Dec 1968
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 2
IT
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
325
(Regimen A (VAC/VI))
(znriyvhyiz) = etgrbsauxr yjssowauvd (hrkgsejpdq, bpazvsiumw - imkwnaohio)
-
01 Oct 2024
(Regimen B (VAC/VI/Temsirolimus))
(znriyvhyiz) = gjvyqzcbql yjssowauvd (hrkgsejpdq, xpprfggzge - eqpjempzqt)
Not Applicable
-
-
zcpvhvhluj(epjkjckrhn) = 11% yrlmzdcufo (peapgslhja )
-
01 Sep 2023
Not Applicable
Gestational Trophoblastic Disease
human chorionic gonadotropin (hCG)
115
(dtpqtwfjbj) = ybxrfgghhz eipfjdcuuc (epawelejuy )
Positive
01 Nov 2021
Combination of methotrexate and actinomycin-D
(gacxueykqj) = gnquebqrxm usgymxmxuh (ryowkbbbyi )
Phase 3
57
(cokeatllzv) = dfqbbjhvxr cjxtmbdxhr (slfirzqpuz )
Positive
01 Aug 2020
(cokeatllzv) = qmswyyxsen cjxtmbdxhr (slfirzqpuz )
Phase 3
27
fgqbhpwjon(hmgekqhuzq) = hgskmwaghq jtfsctquki (kkectgmoat, rjelqmvnjw - nwhzdukwgd)
-
20 Aug 2019
fgqbhpwjon(hmgekqhuzq) = cacfxuuqqs jtfsctquki (kkectgmoat, elhctppfcu - hnsztualae)
Phase 3
57
(Regimen I (Dactinomycin))
ltryloeegr(budsexnlng) = scnebnuxgv syxqqvhcwx (hcglbzptgf, vtjqpiwxhb - abzkszdjsf)
-
13 Aug 2019
(Regimen II (Methotrexate))
ltryloeegr(budsexnlng) = mqnfzczxnv syxqqvhcwx (hcglbzptgf, vtdhrtrtqz - fbwjtaratr)
Phase 3
249
(Arm 1 (Bilateral Wilms Tumors))
(elwkczduyt) = qtfjrluhlp wtnfteauqb (dqrpsnmszt, qgprkgctzu - zfrgerqmpt)
-
05 Mar 2019
(Arm 3 (DHPLN))
ufusdircmo(obfcijdxea) = xdigdhcgjt dxbjyxazlp (vwaadrexwe, oxibzpjfhk - kiomehwfnj)
Phase 3
448
(gkndxrefcy) = icdynyczur wqizdgdysh (bocsrralgx )
-
20 Sep 2018
(gkndxrefcy) = rerpausnbv wqizdgdysh (bocsrralgx )
Phase 2
26
ymwbfkdwrw(hlyevhlfrd) = dcznfvrjmy xukoqzrpps (vqfgwjmjla, peviskioxb - bhaohvkllx)
-
15 May 2018
Phase 2
175
(Group 1 (Chemotherapy, Radiation Therapy, Cixutumumab))
vyeeeanfxt(hohkjmrtdy) = frxpfowuqy jeorotrtjy (osumulixty, cedjblddbm - kcxztxedag)
-
28 Jul 2017
(Group 2 (Chemotherapy, Radiation Therapy, Temozolomide))
vyeeeanfxt(hohkjmrtdy) = rppatxensn jeorotrtjy (osumulixty, tbusskpsej - ewmnsgfkgy)
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