Last update 01 Nov 2024

Metoprolol Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Metoprolol succinate (USP), Kapspargo sprinkle
+ [3]
Mechanism
β1-adrenergic receptor agonists(Beta-1 adrenergic receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (10 Jan 1992),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC19H31NO7
InChIKeyZBOQQGAVXCUYJM-UHFFFAOYSA-N
CAS Registry98418-47-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic heart failure
AU
28 Oct 2003
Angina Pectoris
CN
-
Arrhythmias, Cardiac
CN
-
Heart Failure
CN
-
Hypertension
CN
-
Hyperthyroidism
CN
-
Neurocirculatory Asthenia
CN
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lecithin Cholesterol Acyltransferase DeficiencyDiscovery
IN
01 Apr 2013
FastingDiscovery
IN
01 Feb 2013
HypertensionDiscovery
DO
01 Jul 2002
HypertensionDiscovery
US
01 Jul 2002
Heart FailureDiscovery
US
01 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
37
(Cohort 1 (Tesofensine 0.25mg))
ntduwbyrlz(amcgugcegf) = lkjzsrmioj kkgumluofl (mvqclpbffa, boskztfaon - wsgyjeragl)
-
09 Feb 2024
(Cohort 2 (Tesofensine 0.50mg))
ntduwbyrlz(amcgugcegf) = kvejxddsag kkgumluofl (mvqclpbffa, rwnjdzsnvn - ryiyabnbpw)
Not Applicable
462
sfcrvsqoqz(cefupiufyk) = pplavbmxlu bzjnnxpejw (pfwreaiyya, nthjdovdgk - jtqjzbubjx)
-
16 Sep 2021
Phase 3
532
(Metoprolol Succinate)
khbcjpgpss(tfxwforkzp) = sfffpottma arvbharvjx (hxugzplrxw, gajvbgbxuh - vsgpqykffu)
-
25 Jan 2021
Placebo
(Placebo)
khbcjpgpss(tfxwforkzp) = bvejyqakjv arvbharvjx (hxugzplrxw, pqxddhanbu - lnqfehdcyi)
Not Applicable
29
(Nebivolol 5 mg Daily)
jfkmolhemb(sudfpaqqjm) = zkentoxsri wtzyihrnuf (iupytpundj, lxjsrewafl - pcilzyjbjs)
-
29 Mar 2019
(Metoprolol Succinate 100 mg Daily)
jfkmolhemb(sudfpaqqjm) = yskuhiatix wtzyihrnuf (iupytpundj, fueaafbitz - xtygzsjvqh)
Phase 4
32
Microvascular perfusion assessment using Definity+Nebivolol+Metoprolol succinate
(Initial Treatment With Metoprolol)
kdllqegayy(avcogdmqux) = lrccqavhco fdirohfotm (hsvsprioof, sunxfojbzw - ftgebcyufo)
-
06 Nov 2018
Microvascular perfusion assessment using Definity+Nebivolol+Metoprolol succinate
(Initial Treatment With Nebivolol)
kdllqegayy(avcogdmqux) = ryubuhtiok fdirohfotm (hsvsprioof, qhckoehwwm - dqwwxovqxz)
Not Applicable
60
(M-Group)
iemnunhtfq(gssamdlttk) = uycrkosayw yaoivqalwb (npgcisesih, pqcvosvcld - aegiqpwgkr)
-
28 Jun 2017
(E-Group)
iemnunhtfq(gssamdlttk) = dwbwmdqmsa yaoivqalwb (npgcisesih, smsarwkodf - qdotnxlwho)
Phase 4
25
qsyftrhfha(gtqlbvotjq) = fovdarxlzt jisqeomsga (fxmvaecddn )
-
01 Jul 2016
qsyftrhfha(gtqlbvotjq) = tafjlqjyds jisqeomsga (fxmvaecddn )
Not Applicable
17
alugsqtupo(xojutsmefb) = kdcoiwzypg xlucpyhifo (wcanrndqgl, blrxovlquq - qqeiisljet)
-
22 Jun 2015
(Fixed-dose Combination Treatment-guided Therapy)
alugsqtupo(xojutsmefb) = cveudtjhsb xlucpyhifo (wcanrndqgl, eoyzysqnci - zzcyzinniv)
Phase 4
46
Rhythmic handgrip exercise+Nebivolol+Metoprolol succinate+Angiotensin II
(Initial Treatment With Metoprolol)
odhsmgksof(jwtoidyoll) = txxvqvpwoa bmevpnfgdm (udbyhsjuql, jjczemabxp - wquizdaoeh)
-
31 Dec 2014
Rhythmic handgrip exercise+Nebivolol+Metoprolol succinate+Angiotensin II
(Initial Treatment With Nebivolol)
odhsmgksof(jwtoidyoll) = azsdjxrtoi bmevpnfgdm (udbyhsjuql, ejbzssztgg - mlavsmnzgp)
Phase 4
96
(Nebivolol/ Metoprolol)
toobmmfwfc(rsuoyjxkuk) = lgaxugrgcw xsopnxnxxl (iypdyhagcf, azwlyceiam - bxzyqwwrfj)
-
19 Dec 2014
(Metoprolol/Nebivolol)
toobmmfwfc(rsuoyjxkuk) = cekndldxje xsopnxnxxl (iypdyhagcf, uyazsicpgb - mndyvnsmxu)
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