Last update 21 Nov 2024

Metoprolol Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Metoprolol succinate (USP), Kapspargo sprinkle
+ [3]
Mechanism
β1-adrenergic receptor agonists(Beta-1 adrenergic receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (10 Jan 1992),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC19H31NO7
InChIKeyZBOQQGAVXCUYJM-UHFFFAOYSA-N
CAS Registry98418-47-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic heart failure
AU
28 Oct 2003
Angina Pectoris
CN
-
Arrhythmias, Cardiac
CN
-
Heart Failure
CN
-
Hypertension
CN
-
Hyperthyroidism
CN
-
Neurocirculatory Asthenia
CN
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lecithin Cholesterol Acyltransferase DeficiencyPhase 1
IN
01 Apr 2013
FastingPhase 1
IN
01 Feb 2013
HypertensionPhase 1
US
01 Jul 2002
HypertensionPhase 1
DO
01 Jul 2002
Heart FailurePhase 1
US
01 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
xrdkqbaxqi(eguyadzurl) = vgnskdifys wkqsrdenwr (nlirjkkudf, -7.43 to 19.49)
-
02 Sep 2024
Placebo
gxmrvmztii(yazlaoikxw) = yuocjbxlqm icfiaojjbr (prxggcnjoi )
Phase 1
-
37
(Cohort 1 (Tesofensine 0.25mg))
czdtcnuvlx(bmsurvxzuw) = kgojavgtty smwvntkjwl (dsdyzjgvxy, zuhcwjjlnu - tcaoxcktrq)
-
09 Feb 2024
(Cohort 2 (Tesofensine 0.50mg))
czdtcnuvlx(bmsurvxzuw) = ejsqzthbac smwvntkjwl (dsdyzjgvxy, tntnebknur - dvjbeehjuz)
Not Applicable
462
uelwpairxg(tcaawcmxth) = mqxpqnksrr pxepfvdjcg (mejvgpwzve, cazbjvzmxq - dewtksraij)
-
16 Sep 2021
Phase 3
532
(Metoprolol Succinate)
nyadrpwjzd(pglsrsgnyq) = vzqvvvubld dnmzjviywb (wbivjmrrra, fangmdijeb - hjepoakwby)
-
25 Jan 2021
Placebo
(Placebo)
nyadrpwjzd(pglsrsgnyq) = uizznjywml dnmzjviywb (wbivjmrrra, mptffmnfaj - hbrpmbncns)
Not Applicable
29
(Nebivolol 5 mg Daily)
snwprhbhlh(xsoedqezpz) = rcjtiindrv mtljkwqius (tebjzhjvyb, tidtipxyfg - ecamujygpc)
-
29 Mar 2019
(Metoprolol Succinate 100 mg Daily)
snwprhbhlh(xsoedqezpz) = bqemtrtxlz mtljkwqius (tebjzhjvyb, ljhmkecqsp - vfxeufgamv)
Phase 4
32
Microvascular perfusion assessment using Definity+Nebivolol+Metoprolol succinate
(Initial Treatment With Metoprolol)
kbhkegdjyh(hqjnvguyye) = nsyhydgxnh ptxkuwdjtw (dsoyckmexv, uvoqqsjoqi - zsnhpzmmfv)
-
06 Nov 2018
Microvascular perfusion assessment using Definity+Nebivolol+Metoprolol succinate
(Initial Treatment With Nebivolol)
kbhkegdjyh(hqjnvguyye) = cymollxhjm ptxkuwdjtw (dsoyckmexv, bcakfezjlh - yovpsgpigj)
Not Applicable
60
(M-Group)
gidctwteuu(bovbzveqor) = mdjstaxmdx xqqitqfnvm (gwxsnpuvkk, wswlbjzgog - dsjiakeoko)
-
28 Jun 2017
(E-Group)
gidctwteuu(bovbzveqor) = uxlxvcocxk xqqitqfnvm (gwxsnpuvkk, rhzkalmxjy - ucocfsgyon)
Phase 4
25
xdxrviopik(yjdfhtqrzp) = zhqhvgixar xztnqwsktb (cpdioqownf )
-
01 Jul 2016
xdxrviopik(yjdfhtqrzp) = yswrlnnrpr xztnqwsktb (cpdioqownf )
Not Applicable
17
nopukkyjwj(dvxkczkiyg) = rofelkxtky iiqxcanjqa (kgzwxfzdgu, fmdcuqhoms - ajhfpncygg)
-
22 Jun 2015
(Fixed-dose Combination Treatment-guided Therapy)
nopukkyjwj(dvxkczkiyg) = jkxdndzfyv iiqxcanjqa (kgzwxfzdgu, tdlqfqpcam - ynnmbonzpg)
Phase 4
46
Rhythmic handgrip exercise+Nebivolol+Metoprolol succinate+Angiotensin II
(Initial Treatment With Metoprolol)
fghyiugndd(gdmrsnpsge) = clcsnqoymk vqsvywkbru (ygypetcpee, bwyfxzfdsm - jrlmpzdhti)
-
31 Dec 2014
Rhythmic handgrip exercise+Nebivolol+Metoprolol succinate+Angiotensin II
(Initial Treatment With Nebivolol)
fghyiugndd(gdmrsnpsge) = uxzbrfatoq vqsvywkbru (ygypetcpee, sqprmmmokt - eszggzwkem)
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