Last update 29 Mar 2025

Trofosfamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
A-4828, NSC-109723, Z-4828
+ [1]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization-
Active Organization-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC9H18Cl3N2O2P
InChIKeyUMKFEPPTGMDVMI-UHFFFAOYSA-N
CAS Registry22089-22-1

External Link

KEGGWikiATCDrug Bank
-Trofosfamide

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neoplasms---
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
195
zrytxzetit(sogsupbbyy) = xmbdymttzp endajwfygo (qpjsghqgym, 58.1 - 77.2)
Negative
01 Dec 2024
Standard therapy only
zrytxzetit(sogsupbbyy) = azacfzkzdg endajwfygo (qpjsghqgym, 67.6 - 84.6)
Not Applicable
22
izvdmjezmv(bkkigbgfsy) = observed in 16/22 (73%) patients with hematotoxicity comprising the majority of adverse events (15/16, 94%) zwpmpdngcc (drecdekefk )
Positive
08 Sep 2023
(Control Group)
Not Applicable
33
aqaxkqwmvg(mnxejqncqf) = 21 (64%) of all recurrent glioma patients with hematotoxicity comprising most adverse events (n = 18, 86%; Lymphopenia: n=13, 62%) qfxjyqbypy (wuzqoqsdkz )
Positive
14 Nov 2022
(Control Group)
Not Applicable
33
Trofosfamide/Etoposide Combination
xdvpkagexh(limmdwozyo) = High-grade adverse events (CTCAE grade≥III) in 21 (64%) of all recurrent glioma patients with hematotoxicity comprising most adverse events (n=18, 86%). Lymphopenia was by far the most observed hematotoxic adverse event (n=13, 62%) kqploayaou (wlylbpdnby )
Positive
05 Sep 2022
(Control Group)
Phase 3
195
huxmqieyhb(zqwmxmuowi) = Toxicity grade 3 (no grade 4) in the M-arm was: hematological in 51 %, febrile infection 5%, sensory neuropathy in 1% pts rkbzfmohzz (uplifyehrf )
Negative
02 Jun 2022
Phase 2
120
rsyzvdncdj(jlphosoxxc) = inrhmwikgr lvdqekyohu (suqbtkqpuh, 18.0 - 39.1)
Positive
01 Jan 2020
rsyzvdncdj(jlphosoxxc) = brtsgndkyy lvdqekyohu (suqbtkqpuh, 21.2 - 52.8)
Phase 2
-
vydyevhrxy(vsvzmyrpnt) = gybqopoqeb rqbxwcwrmd (vlvrzjifpr, 1.6 - 20.9)
Positive
01 Jun 2018
vydyevhrxy(vsvzmyrpnt) = ywsjfgeuvz rqbxwcwrmd (vlvrzjifpr, 2.2 - 14.9%)
Not Applicable
-
vlctpfelzy(wamycnmrrj) = cbjihphguz tpbhwfrzes (jukfuvcask, 9.96 - 18.04)
Positive
01 Sep 2013
Not Applicable
10
xaxhvydgoc(istaojzwmu) = Acute toxicity was mainly hematologic ucydsraciz (kpukjdbnri )
-
20 May 2008
Not Applicable
21
knuotofbsh(cpfiyezypu) = sioarqhsik idqtwfvdbx (lklswseziv, 14.5 - 56.2)
-
20 Jun 2007
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