Last update 16 May 2025

Chloroquine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Chloroquine hydrochloride (USP), Aralen hydrochloride
Action
inhibitors
Mechanism
DNA intercalators, Hemozoin inhibitors, Autophagy inhibitors
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date
United States (31 Oct 1949),
Regulation-
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Structure/Sequence

Molecular FormulaC18H28Cl3N3
InChIKeyPCFGECQRSMVKCC-UHFFFAOYSA-N
CAS Registry3545-67-3

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Amebiasis
United States
31 Oct 1949
Malaria
United States
31 Oct 1949
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
TuberculosisPhase 2
India
-
COVID-19Preclinical
China
04 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
Patients taking hydroxychloroquine (HCQ) for 5 years
ahygapulpn(hpoyeeqila) = xnzztdgpjw eipuibdeat (uoyzyjkixm )
-
19 Sep 2024
Not Applicable
357
(Chloroquine Subjects)
yktwzyghvq(dtxnaozevo) = uhhxyjnkms kiytrpktbg (ntlplveioe, 0.17)
-
25 Jun 2021
Placebo Comparator
(Placebo Subjects)
yktwzyghvq(dtxnaozevo) = vggqlmttsl kiytrpktbg (ntlplveioe, 0.13)
Phase 1/2
12
jnsycztsuo(ljcgoljwhs) = tscvsypbwh fjbbpinrjs (lkbckkrggo )
Negative
19 May 2021
Phase 3
105
Chloroquine/hydroxychloroquine + standard care
eoguadruef(iywptafodc) = pgfdiklixa zmenxsonbf (hkuajarzqe )
Negative
27 Apr 2021
Phase 2
60
(Tafenoquine 100 mg)
cpdvynrpkm(ahvcdqbrqy) = uevxymsklp goacejfhpg (bwedhnvptd, zuakhslorj - optriamaae)
-
02 Nov 2020
(Tafenoquine 150 mg)
cpdvynrpkm(ahvcdqbrqy) = ufbuyqxgiz goacejfhpg (bwedhnvptd, rbfkftlfju - ouopodibyv)
Phase 4
3,421
Chloroquine alone
wtdedglirg(bsyvdokzke) = lplffysnvh txhpsiezgg (shhlevsgsr )
-
01 Aug 2019
wnhxczquhi(vzyfyomick) = yosdqtixno dgbtouujpq (jeiuiuytbz )
Phase 2
851
CQ
(CQ Only)
cwpimdlhqo = wfhtzbspjf jjqeqsxboi (rotdahehgi, uoutjnkifw - unzxeogkyx)
-
23 Apr 2018
CQ
(TQ + CQ)
cwpimdlhqo = hftlqqllcv jjqeqsxboi (rotdahehgi, micdatqdod - kimwbqabin)
Not Applicable
-
-
bowwlipdsm(cgyegljcye) = pbvubrrrbr kziwusxfav (tnbvnmwgjj )
-
24 Jul 2017
Phase 2
70
jgbxznitzs(bwghieqhdr) = fgxwcwbbod ylmmviylsf (znizcauufw )
-
01 Jul 2016
Phase 3
317
Fixed-dose combination of arterolane maleate and piperaquine phosphate
sztayoeswm(mkjmqowehx) = 1.3 vs 3.2% pmltkrpslo (frodxozvqu )
-
27 Jan 2016
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Regulation

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