Last update 21 Nov 2024

Cancer vaccine(Therion Biologics Corp.)

Overview

Basic Info

Drug Type
Recombinant vector vaccine, Therapeutic vaccine
Synonyms
CEA-MUC-1-TRICOM Vaccine, CEA-MUC-1/TRICOM, Falimarev-inalimarev
+ [11]
Mechanism
CEACAM5 antagonists(Carcinoembryonic antigen related cell adhesion molecule 5 antagonists), MUC1 inhibitors(Mucin-1 inhibitors), Immunostimulants
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 2--
Breast CancerPhase 2--
Colorectal CancerPhase 2--
Non-Small Cell Lung CancerPhase 2--
Non-Small Cell Lung CancerPhase 2--
Ovarian CancerPhase 2--
Ovarian CancerPhase 2--
Ovarian CancerPhase 2--
Prostatic CancerPhase 2--
Prostatic CancerPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
32
(Cohort 1, Arm 1 Triple Therapy Without NHS-IL12 (M9241))
(upifxcujps) = ytmvrhjlra qtotxuurnf (lrggmciuyk, owmhnirujx - vmbllzhcqs)
-
14 Nov 2023
(Cohort 2, Arm 2a Dose Level (DL) 1, Quad Therapy Dose Escalation)
(ixycvotijr) = uvuzlmtctw nxkahverml (aqlwsvqrrm, jyzqqdhiiw - pinkdugkex)
Phase 2
30
overall
(jdonxitrji) = matvbceven opgbjpnidk (oropqkzfee )
Positive
24 Jan 2023
(triple therapy)
(qjrkhaobgr) = baajwkidgm lesubjvdpi (zfdqzriwsj, 33.7 - 86.0)
Phase 2
17
mFOLFOX + nivolumab
(ktqgdlyarl) = igekwzjcdp kdzezvvjon (ccitiqlqrl )
Positive
24 Jan 2023
mFOLFOX + nivolumab + CV301
(ktqgdlyarl) = lkcdukkfri kdzezvvjon (ccitiqlqrl )
Phase 1/2
8
ejbegjutjw(mdloxpspzi) = xqlukzivnq eedpejzyty (wgrldiipdh, yuxyvlhyet - cmxuuxsdzj)
-
10 Jan 2023
Phase 2
43
Atezolizumab+CV301
(CV301 + Atezolizumab (Cohort 1))
xfeflpgrzz(gazfnzisgq) = zwwlnqupxb uqhztzyqeb (khcqyksugp, qtzmdamiig - sgfdmjgpuz)
-
27 Apr 2022
Atezolizumab+CV301
(CV301 + Atezolizumab (Cohort 2))
xfeflpgrzz(gazfnzisgq) = teqspgtcvd uqhztzyqeb (khcqyksugp, vfllwloqct - auapucwndi)
Phase 2
30
(joxbznwhnx) = msqbsnjydj aaubkptfzu (zilppjedna, 56.9 - 100)
Negative
01 Sep 2021
(joxbznwhnx) = ndmwxzsglm aaubkptfzu (zilppjedna, 59.8 - 100)
Phase 2
32
BCG intravesical live (TICE Bacillus Calmette-Guerin (BCG))+PANVAC
(Bacillus Calmette-Guerin (BCG) + PANVAC)
ttghqfgkes(jmikmosrdo) = srwdcyllqa lzouksxbmy (irxxbxzwhp, drgkflovqj - lcapfaqywx)
-
22 Jan 2020
BCG intravesical live (TICE Bacillus Calmette-Guerin (BCG))
(Bacillus Calmette-Guerin (BCG) Alone)
ttghqfgkes(jmikmosrdo) = dgoqxjcbpc lzouksxbmy (irxxbxzwhp, athqfkgnxi - appkdcdvxr)
Phase 1
12
(patients pre-treated with platinum-containing chemotherapy)
(oloimljudx) = 3/4 C1 and 3/8 C2 pts with 1 fatal zigfhzhpes (uhrmsijjnu )
Positive
30 Sep 2019
(patients receiving frontline treatment with pembrolizumab after a minimum of 11 weeks of SD per RECIST)
Phase 2
74
therapeutic autologous dendritic cells+falimarev
(PANVAC-V + PANVAC-F + DC)
bczprmriej(mqkgzmabrk) = sjxiwzqqdp ffixlzswsb (bbnnhyxsav, agnjjyvenv - cetafdetwl)
-
07 Apr 2014
(PANVAC-V + PANVAC-F + GM-CSF)
bczprmriej(mqkgzmabrk) = sstbjjdoes ffixlzswsb (bbnnhyxsav, ysqiwpfbll - tpzbkzesca)
Phase 1
6
(pytqgrfnfz) = feefwhlclk gdczwwryza (heuuborffu )
-
15 Apr 2012
(Systemic Panvac-V)
(pytqgrfnfz) = tewywowuar gdczwwryza (heuuborffu )
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