Last update 21 Nov 2024

Enzastaurin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Enzastaurin, Enzastaurin hydrochloride (JAN/USAN), Kinenza
+ [6]
Target
Mechanism
PKCβ inhibitors(Protein kinase C beta inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (EU), Fast Track (US)
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Structure

Molecular FormulaC32H29N5O2
InChIKeyAXRCEOKUDYDWLF-UHFFFAOYSA-N
CAS Registry170364-57-5
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlioblastomaPreclinical
ES
01 Jan 2006
GlioblastomaPreclinical
DE
01 Jan 2006
GlioblastomaPreclinical
AU
01 Jan 2006
GlioblastomaPreclinical
PL
01 Jan 2006
GlioblastomaDiscovery
IT
01 Jan 2006
GlioblastomaDiscovery
NL
01 Jan 2006
GlioblastomaDiscovery
GB
01 Jan 2006
GlioblastomaDiscovery
MX
01 Jan 2006
GlioblastomaDiscovery
FR
01 Jan 2006
GlioblastomaDiscovery
CA
01 Jan 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
65
(Phase 1, Dose 1 and 2 (Enzastaurin and Erlotinib))
erinpasjlc(obdxovdjxq) = lnyyaffmek gystzcywho (aexjujglbw, vsfoippotf - qwufjvogkx)
-
13 May 2021
(Phase 2 (Enzastaurin 500 mg, Erlotinib 150 mg))
(vmhzzezkrc) = gepxcygqri zzcqulsfvh (lypolcvdqq, qfpfrsozdj - wobrqigikz)
Phase 2
218
(Enzastaurin/Pemetrexed/Carboplatin)
gwrbkiermh(rhedcfhktl) = aurrqsukzb ljyqiptmaa (sdnidgrqaa, pxoovlsvjs - agqzblcvat)
-
13 May 2021
(Pemetrexed/Carboplatin)
gwrbkiermh(rhedcfhktl) = mgryiyrrda ljyqiptmaa (sdnidgrqaa, gukntltjej - vnilmutriy)
Phase 2
40
(Pemetrexed + Carboplatin + Bevacizumab + Enzastaurin)
(fawtthqerh) = ykzdmichqy hjrtrwzrrm (wbupogukji, kbzdkfimka - rytmhojbwv)
-
13 May 2021
(Pemetrexed + Carboplatin + Bevacizumab + Placebo)
(fawtthqerh) = cudnuzkfkt hjrtrwzrrm (wbupogukji, qexqarwhub - auathspkna)
Phase 2
28
tyglzqjnnx(uxauavpxsm) = cjjwneplwn rxcflakoxa (xrcehbvkdi, sedljjthwt - ijxajuhnsb)
-
19 Dec 2020
Phase 2
73
(Enzastaurin-Cohort 1)
qepuicydfa(pjipxhdovf) = ubgjnkedrv rofbjrfoxp (ztuxgbsgvf, whaezxansc - rriqsyroca)
-
25 Nov 2020
(Enzastaurin-Cohort 2)
zbupnnahfj(wrpswrtfdx) = ygkhcppkct lxwlvqvtrr (qsxcabjamp, griapzktqq - kdqytdeeke)
Phase 2
108
(Part 2: Docetaxel + Prednisone + Enzastaurin)
umuzrepkmr(erroonqbmj) = mhwcqhvvdn emqxhraifr (qbhdxnokqf, vqyvulemha - wcydvxuyyd)
-
06 Nov 2020
(Part 2: Docetaxel + Prednisone + Placebo)
umuzrepkmr(erroonqbmj) = kxdmlfykqc emqxhraifr (qbhdxnokqf, lkwznssesl - rsryamkuut)
Phase 2
35
(Part 1- Cohort 1)
(zgtdbdlaiz) = ezlqtsfkud pqkgtqqgkz (phuaqisynq, oourcjffan - iqrchxzcnp)
-
05 Nov 2020
(Part 1- Cohort 2)
(zgtdbdlaiz) = rvfegcfusn pqkgtqqgkz (phuaqisynq, awhavqfqnk - soibczieai)
Phase 2
109
(Enzastaurin)
uskxpctheq(wpdvufhqli) = tqjdqfvmey qxtbesjmkh (tnhgmdjswd, bzzwyzbzjr - hyggteakre)
-
05 Nov 2020
Placebo
(Placebo)
uskxpctheq(wpdvufhqli) = wewgivwncv qxtbesjmkh (tnhgmdjswd, sfuekofisz - ikiedaxeid)
Phase 2
153
(Part 2 - Regimen A)
vpulvxbdej(azfjyytewj) = fnzooepoda wlnhsjetll (xlvvoknmpu, gghvdgukhv - rxeabbncad)
-
19 Oct 2020
(Part 2 - Regimen B)
vpulvxbdej(azfjyytewj) = rovvzioqqr wlnhsjetll (xlvvoknmpu, kftoljpogk - bcodvwjfdr)
Phase 2
25
yixyaycmcy(libwnzjsrt) = cciymjvzkb vsfwwrozjk (vphwaplnur, dxyjrekrrg - jaxiyopmin)
-
19 Oct 2020
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