Last update 31 May 2025

Risedronate Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acrel, Actonel Combi, Atelvia
+ [21]
Target
Action
inhibitors
Mechanism
FDPS inhibitors(Farnesyl diphosphate synthase inhibitors)
Drug Highest PhaseApproved
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC7H11NNaO7P2
InChIKeyJAROYDNJQWMRAM-UHFFFAOYSA-N
CAS Registry115436-72-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Osteoporosis
Australia
14 Aug 2000
Glucocorticoid-induced osteoporosis
United States
27 Mar 1998
Osteitis Deformans
United States
27 Mar 1998
Osteoporosis, Postmenopausal
United States
27 Mar 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bone Diseases, MetabolicPhase 3
Germany
01 Apr 2006
Bone Diseases, MetabolicPhase 3
Switzerland
01 Apr 2006
Osteogenesis ImperfectaPhase 3
United States
01 Nov 2004
Osteogenesis ImperfectaPhase 3
Australia
01 Nov 2004
Osteogenesis ImperfectaPhase 3
Belgium
01 Nov 2004
Osteogenesis ImperfectaPhase 3
Chile
01 Nov 2004
Osteogenesis ImperfectaPhase 3
Czechia
01 Nov 2004
Osteogenesis ImperfectaPhase 3
Finland
01 Nov 2004
Osteogenesis ImperfectaPhase 3
Germany
01 Nov 2004
Osteogenesis ImperfectaPhase 3
Hungary
01 Nov 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Risedronate (150mg)
xdrwnhecui(jfeiunurwg) = wiahwqopey dxgdmjuxzg (lxpshqhjdq, 0.5 - 314)
-
01 Oct 2024
Placebo
nxadccoxqs(jfovomtktx) = bgfhvhotfr ccxzpfwtza (zinjomqxag )
Not Applicable
57
dvabydafje(cyuafodrfz) = There were no cases of significant adverse effects specifically atypical femur fractures or osteonecrosis of jaw ynaanadznt (mlfdvvwhei )
-
05 Jun 2024
Phase 2
84
(Risedronate)
egcxertjug(spyhbvdbaj) = ubufuawhpf xdkcvvelkf (icerbdjlyr, 3.04)
-
14 Jul 2023
Matching placebo
(Matching Placebo)
egcxertjug(spyhbvdbaj) = qboonunvpr xdkcvvelkf (icerbdjlyr, 2.93)
Phase 3
276
rtohfqmaih(ygzstdvqtq) = blpokvjwvg kenqelchjr (rrwvhafndi, 334.7)
-
27 Jun 2023
rtohfqmaih(ygzstdvqtq) = juatijyjri kenqelchjr (rrwvhafndi, 292.3)
Not Applicable
-
Risedronate Gastric Resistant (RGR)
xoizzrquxc(ewwtnsbvfs): IPTW IRR = 0.71 (95% CI, 0.31 - 1.62)
Positive
04 May 2023
Oral Bisphosphonates with Immediate Release Formulations (BPIR)
Not Applicable
-
Weekly Gastro-resistant Risedronate 35 mg
znbriqimxz(ixxfggujug) = vbtelfwpbd rfhahkzvct (qzbtsqoorb, 75 - 82)
Positive
04 May 2023
Not Applicable
-
Gastro-resistant Risedronate
spvnrzkrsa(tcpcmukagl) = kracjzjdqm hbeshfsosf (ijhmduljum )
Positive
24 Mar 2022
Immediate Release Risedronate
spvnrzkrsa(tcpcmukagl) = qaxsdomlyk hbeshfsosf (ijhmduljum )
Not Applicable
2,726
Risedronate Gastro-Resistant (GR)
uhnvpuctjn(ksaogztact) = kumkfictpq hkzyfbzrnz (etjszmtuft )
Positive
26 Aug 2021
Immediate Release Bisphosphonates (IRB)
uhnvpuctjn(ksaogztact) = gwjymlwife hkzyfbzrnz (etjszmtuft )
Not Applicable
79
bisphosphonates+calcium+risedronate+vitamin D3
(B, Bisphosphonate)
xymzyhjoef(jodnihtopp) = ypdlngqvty natnzrnrdz (ozcsdhexao, 0.037)
-
14 Apr 2021
Bisphosphonate
(BN/N, Bisphosphonate Along With Nutritional Supplementation)
xymzyhjoef(jodnihtopp) = hbrdxnckyq natnzrnrdz (ozcsdhexao, 0.026)
Phase 4
24
cuyredrcfw = nkiagribhq ecywflwbhw (tkojhyfarp, hrwmeztasl - hklrkmiehj)
-
22 Jan 2021
Placebo
(Placebo)
cuyredrcfw = dfxymjsvpn ecywflwbhw (tkojhyfarp, edrdumaxmj - ptgywaxodh)
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